Metabolic Reprogramming and Vulnerabilities in Cancer

por Lyssiotis, Costas A., Nagrath, Deepak
Publicado 2019

Metabolic regulation of ferroptosis in the tumor microenvironment

por Mbah, Nneka E., Lyssiotis, Costas A.
Publicado 2022

Metabolic Regulation of Redox Balance in Cancer

por Purohit, Vinee, Simeone, Diane M., Lyssiotis, Costas A.
Publicado 2019

Amino acid metabolism in primary bone sarcomas

por Jiménez, Jennifer A., Lawlor, Elizabeth R., Lyssiotis, Costas A.
Publicado 2022

Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP(+)-Dependent Malic Enzyme 1

por Yoshida, Tomohiro, Kawabe, Tetsuhiro, Cantley, Lewis C., Lyssiotis, Costas A.
Publicado 2022

Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

por Lyssiotis, Costas A., Son, Jaekyoung, Cantley, Lewis C., Kimmelman, Alec C.
Publicado 2013

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase

por Mullarky, Edouard, Lairson, Luke L., Cantley, Lewis C., Lyssiotis, Costas A.
Publicado 2016

The biological underpinnings of therapeutic resistance in pancreatic cancer

por Beatty, Gregory L., Werba, Gregor, Lyssiotis, Costas A., Simeone, Diane M.
Publicado 2021

Common biochemical properties of metabolic genes recurrently dysregulated in tumors

por Oruganty, Krishnadev, Campit, Scott Edward, Mamde, Sainath, Lyssiotis, Costas A., Chandrasekaran, Sriram
Publicado 2020

A Cross-Species Analysis of a Mouse Model of Breast Cancer-Specific Osteolysis and Human Bone Metastases Using Gene Expression Profiling

por Sadanandam, Anguraj, Futakuchi, Mitsuru, Lyssiotis, Costas A, Gibb, William J, Singh, Rakesh K
Publicado 2011

A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics

por Lee, Ho-Joon, Kremer, Daniel M., Sajjakulnukit, Peter, Zhang, Li, Lyssiotis, Costas A.
Publicado 2019

NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function

por Kumar, Ajay, Yarosz, Emily L., Andren, Anthony, Zhang, Li, Lyssiotis, Costas A., Chang, Cheong-Hee
Publicado 2022

Spotlight on GOT2 in Cancer Metabolism

por Kerk, Samuel A, Garcia-Bermudez, Javier, Birsoy, Kivanc, Sherman, Mara H, Shah, Yatrik M, Lyssiotis, Costas A
Publicado 2023

Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer

por Lien, Evan C., Lyssiotis, Costas A., Juvekar, Ashish, Hu, Hai, Asara, John M., Cantley, Lewis C., Toker, Alex
Publicado 2016

Auditory metabolomics, an approach to identify acute molecular effects of noise trauma

por Ji, Lingchao, Lee, Ho-Joon, Wan, Guoqiang, Wang, Guo-Peng, Zhang, Li, Sajjakulnukit, Peter, Schacht, Jochen, Lyssiotis, Costas A., Corfas, Gabriel
Publicado 2019

A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H(2)S oxidation

por Kumar, Roshan, Landry, Aaron P., Guha, Arkajit, Vitvitsky, Victor, Lee, Ho Joon, Seike, Keisuke, Reddy, Pavan, Lyssiotis, Costas A., Banerjee, Ruma
Publicado 2021

PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool

por Chen, Brandon, Das, Nupur K., Talukder, Indrani, Singhal, Rashi, Castillo, Cristina, Andren, Anthony, Mancias, Joseph D., Lyssiotis, Costas A., Shah, Yatrik M.
Publicado 2023

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

por Yang, Weiwei, Zheng, Yanhua, Xia, Yan, Ji, Haitao, Chen, Xiaomin, Guo, Fang, Lyssiotis, Costas A., Aldape, Kenneth, Cantley, Lewis C., Lu, Zhimin
Publicado 2012

Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption

por Zhu, Lingxin, Tang, Yi, Li, Xiao-Yan, Kerk, Samuel A., Lyssiotis, Costas A., Sun, Xiaoyue, Wang, Zijun, Cho, Jung-Sun, Ma, Jun, Weiss, Stephen J.
Publicado 2023

Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis

por Wubben, Thomas J., Pawar, Mercy, Weh, Eric, Smith, Andrew, Sajjakulnukit, Peter, Zhang, Li, Dai, Lipeng, Hager, Heather, Pai, Manjunath P., Lyssiotis, Costas A., Besirli, Cagri G.
Publicado 2020