Targeting ER-Mitochondria Signaling as a Therapeutic Target for Frontotemporal Dementia and Related Amyotrophic Lateral Sclerosis

por Martín-Guerrero, Sandra M., Markovinovic, Andrea, Mórotz, Gábor M., Salam, Shaakir, Noble, Wendy, Miller, Christopher C. J.
Publicado 2022

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

por Mórotz, Gábor M., De Vos, Kurt J., Vagnoni, Alessio, Ackerley, Steven, Shaw, Christopher E., Miller, Christopher C.J.
Publicado 2012

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

por Rodríguez-Martín, Teresa, Pooler, Amy M., Lau, Dawn H.W., Mórotz, Gábor M., De Vos, Kurt J., Gilley, Jonathan, Coleman, Michael P., Hanger, Diane P.
Publicado 2016

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

por De Vos, Kurt J., Mórotz, Gábor M., Stoica, Radu, Tudor, Elizabeth L., Lau, Kwok-Fai, Ackerley, Steven, Warley, Alice, Shaw, Christopher E., Miller, Christopher C.J.
Publicado 2012

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains

por Mórotz, Gábor M., Glennon, Elizabeth B., Gomez-Suaga, Patricia, Lau, Dawn H. W., Robinson, Eleanor D., Sedlák, Éva, Vagnoni, Alessio, Noble, Wendy, Miller, Christopher C. J.
Publicado 2019

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein

por Mórotz, Gábor M., Glennon, Elizabeth B., Greig, Jenny, Lau, Dawn H. W., Bhembre, Nishita, Mattedi, Francesca, Muschalik, Nadine, Noble, Wendy, Vagnoni, Alessio, Miller, Christopher C. J.
Publicado 2019

Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain

por Lau, Dawn H.W., Paillusson, Sebastien, Hartopp, Naomi, Rupawala, Huzefa, Mórotz, Gábor M., Gomez-Suaga, Patricia, Greig, Jenny, Troakes, Claire, Noble, Wendy, Miller, Christopher C.J.
Publicado 2020

The PTPIP51 coiled-coil domain is important in VAPB binding, formation of ER-mitochondria contacts and IP3 receptor delivery of Ca(2+) to mitochondria

por Mórotz, Gábor M., Martín-Guerrero, Sandra M., Markovinovic, Andrea, Paillusson, Sebastien, Russell, Matthew R. G., Machado, Pedro M. Pereira, Fleck, Roland A., Noble, Wendy, Miller, Christopher C.J.
Publicado 2022

The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

por Gómez-Suaga, Patricia, Pérez-Nievas, Beatriz G., Glennon, Elizabeth B., Lau, Dawn H. W., Paillusson, Sebastien, Mórotz, Gábor M., Calì, Tito, Pizzo, Paola, Noble, Wendy, Miller, Christopher C. J.
Publicado 2019

Disruption of ER−mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis

por Lau, Dawn H. W., Hartopp, Naomi, Welsh, Natalie J., Mueller, Sarah, Glennon, Elizabeth B., Mórotz, Gábor M., Annibali, Ambra, Gomez-Suaga, Patricia, Stoica, Radu, Paillusson, Sebastien, Miller, Christopher C. J.
Publicado 2018

Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis

por Hartopp, Naomi, Lau, Dawn H W., Martin-Guerrero, Sandra M., Markovinovic, Andrea, Mórotz, Gábor M., Greig, Jenny, Glennon, Elizabeth B., Troakes, Claire, Gomez-Suaga, Patricia, Noble, Wendy, Miller, Christopher C.J.
Publicado 2022

Disruption of ER‐mitochondria tethering and signalling in C9orf72‐associated amyotrophic lateral sclerosis and frontotemporal dementia

por Gomez‐Suaga, Patricia, Mórotz, Gábor M., Markovinovic, Andrea, Martín‐Guerrero, Sandra M., Preza, Elisavet, Arias, Natalia, Mayl, Keith, Aabdien, Afra, Gesheva, Vesela, Nishimura, Agnes, Annibali, Ambra, Lee, Younbok, Mitchell, Jacqueline C., Wray, Selina, Shaw, Christopher, Noble, Wendy, Miller, Christopher C. J.
Publicado 2022