Towards the next generation of antimalaria combination therapies

por Möhrle, Jörg J
Publicado 2021

Lost in translation? Bridging the preclinical / clinical divide

por Baker, Mark, Möhrle, Jörg, Austin, Daren
Publicado 2012

Model-informed target product profiles of long-acting-injectables for use as seasonal malaria prevention

por Burgert, Lydia, Reiker, Theresa, Golumbeanu, Monica, Möhrle, Jörg J., Penny, Melissa A.
Publicado 2022

Using Cryopreserved Plasmodium falciparum Sporozoites in a Humanized Mouse Model to Study Early Malaria Infection Processes and Test Prophylactic Treatments

por Jiménez-Díaz, María-Belén, Möhrle, Jörg J., Angulo-Barturen, Iñigo, Demarta-Gatsi, Claudia
Publicado 2023

Pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of Actelion‐451840 in an induced blood stage malaria study in healthy subjects

por Krause, Andreas, Dingemanse, Jasper, Mathis, Alexandre, Marquart, Louise, Möhrle, Jörg J., McCarthy, James S.
Publicado 2016

Designing the next generation of medicines for malaria control and eradication

por Burrows, Jeremy N, Hooft van Huijsduijnen, Rob, Möhrle, Jörg J, Oeuvray, Claude, Wells, Timothy NC
Publicado 2013

Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development

por Burgert, Lydia, Rottmann, Matthias, Wittlin, Sergio, Gobeau, Nathalie, Krause, Andreas, Dingemanse, Jasper, Möhrle, Jörg J., Penny, Melissa A.
Publicado 2020

Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial...

por Andrews, Kayla Ann, Owen, Joel S., McCarthy, James, Wesche, David, Gobeau, Nathalie, Grasela, Thaddeus H., Möhrle, Jörg J.
Publicado 2020

Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers

por McCarthy, James S., Baker, Mark, O'Rourke, Peter, Marquart, Louise, Griffin, Paul, Hooft van Huijsduijnen, Rob, Möhrle, Jörg J.
Publicado 2016

Model-Informed Drug Development for Malaria Therapeutics

por Andrews, Kayla Ann, Wesche, David, McCarthy, James, Möhrle, Jörg J., Tarning, Joel, Phillips, Luann, Kern, Steven, Grasela, Thaddeus
Publicado 2017

DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum

por Collins, Katharine A., Rückle, Thomas, Elliott, Suzanne, Marquart, Louise, Ballard, Emma, Chalon, Stephan, Griffin, Paul, Möhrle, Jörg J., McCarthy, James S.
Publicado 2019

Population Pharmacokinetics and Pharmacodynamics of Chloroquine in a Plasmodium vivax Volunteer Infection Study

por Abd‐Rahman, Azrin N., Marquart, Louise, Gobeau, Nathalie, Kümmel, Anne, Simpson, Julie A., Chalon, Stephan, Möhrle, Jörg J., McCarthy, James S.
Publicado 2020

A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum i...

por McCarthy, James S., Rückle, Thomas, Elliott, Suzanne L., Ballard, Emma, Collins, Katharine A., Marquart, Louise, Griffin, Paul, Chalon, Stephan, Möhrle, Jörg J.
Publicado 2019

First‐in‐human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection

por Chughlay, M. Farouk, Rossignol, Emilie, Donini, Cristina, El Gaaloul, Myriam, Lorch, Ulrike, Coates, Simon, Langdon, Grant, Hammond, Tim, Möhrle, Jörg, Chalon, Stephan
Publicado 2020

Antimalarial Activity of Artefenomel Against Asexual Parasites and Transmissible Gametocytes During Experimental Blood-Stage Plasmodium vivax Infection

por Collins, Katharine A, Abd-Rahman, Azrin N, Marquart, Louise, Ballard, Emma, Gobeau, Nathalie, Griffin, Paul, Chalon, Stephan, Möhrle, Jörg J, McCarthy, James S
Publicado 2020

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase...

por Phyo, Aung Pyae, Jittamala, Podjanee, Nosten, François H, Pukrittayakamee, Sasithon, Imwong, Mallika, White, Nicholas J, Duparc, Stephan, Macintyre, Fiona, Baker, Mark, Möhrle, Jörg J
Publicado 2016

New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations

por Wicha, Sebastian G., Walz, Annabelle, Cherkaoui-Rbati, Mohammed H., Bundgaard, Nils, Kuritz, Karsten, Gumpp, Christin, Gobeau, Nathalie, Möhrle, Jörg, Rottmann, Matthias, Demarta-Gatsi, Claudia
Publicado 2022

A pharmacokinetic–pharmacodynamic model for chemoprotective agents against malaria

por Cherkaoui‐Rbati, Mohammed H., Andenmatten, Nicole, Burgert, Lydia, Egbelowo, Oluwaseun F., Fendel, Rolf, Fornari, Chiara, Gabel, Michael, Ward, John, Möhrle, Jörg J., Gobeau, Nathalie
Publicado 2022

New developments in anti-malarial target candidate and product profiles

por Burrows, Jeremy N., Duparc, Stephan, Gutteridge, Winston E., Hooft van Huijsduijnen, Rob, Kaszubska, Wiweka, Macintyre, Fiona, Mazzuri, Sébastien, Möhrle, Jörg J., Wells, Timothy N. C.
Publicado 2017

Erratum to: New developments in anti-malarial target candidate and product profiles

por Burrows, Jeremy N., Duparc, Stephan, Gutteridge, Winston E., van Huijsduijnen, Rob Hooft, Kaszubska, Wiweka, Macintyre, Fiona, Mazzuri, Sébastien, Möhrle, Jörg J., Wells, Timothy N. C.
Publicado 2017