Inhibition of KIT-Glycosylation by 2-Deoxyglucose Abrogates KIT-Signaling and Combination with ABT-263 Synergistically Induces Apoptosis in Gastrointestinal Stromal Tumor

por Mühlenberg, Thomas, Grunewald, Susanne, Treckmann, Jürgen, Podleska, Lars, Schuler, Martin, Fletcher, Jonathan A., Bauer, Sebastian
Publicado 2015

Prenatal diagnosis and pregnancy outcome of major structural anomalies detectable in the first trimester: A population‐based cohort study in the Netherlands

por Bardi, Francesca, Bergman, Jorieke Elisabertha Hermina, Siemensma‐Mühlenberg, Nicole, Elvan‐Taşpınar, Ayten, de Walle, Hermien Evelien Klaaske, Bakker, Marian Karolien
Publicado 2022

Use of a KIT-specific monoclonal antibody to bypass imatinib resistance in gastrointestinal stromal tumors

por Edris, Badreddin, Willingham, Stephen, Weiskopf, Kipp, Volkmer, Anne K, Volkmer, Jens-Peter, Mühlenberg, Thomas, Weissman, Irving L, van de Rijn, Matt
Publicado 2013

p53 Modulation as a Therapeutic Strategy in Gastrointestinal Stromal Tumors

por Henze, Joern, Mühlenberg, Thomas, Simon, Susanne, Grabellus, Florian, Rubin, Brian, Taeger, Georg, Schuler, Martin, Treckmann, Juergen, Debiec-Rychter, Maria, Taguchi, Takahiro, Fletcher, Jonathan A., Bauer, Sebastian
Publicado 2012

Inhibitor of Apoptosis Proteins (IAPs) are commonly dysregulated in GIST and can be pharmacologically targeted to enhance the pro-apoptotic activity of imatinib

por Falkenhorst, Johanna, Grunewald, Susanne, Mühlenberg, Thomas, Marino-Enriquez, Adrian, Reis, Anna-Carina, Corless, Christopher, Heinrich, Michael, Treckmann, Jürgen, Podleska, Lars Erik, Schuler, Martin, Fletcher, Jonathan Alfred, Bauer, Sebastian
Publicado 2016

Phase I study of panobinostat and imatinib in patients with treatment-refractory metastatic gastrointestinal stromal tumors

por Bauer, S, Hilger, R A, Mühlenberg, T, Grabellus, F, Nagarajah, J, Hoiczyk, M, Reichardt, A, Ahrens, M, Reichardt, P, Grunewald, S, Scheulen, M E, Pustowka, A, Bock, E, Schuler, M, Pink, D
Publicado 2014

Plasma Sequencing for Patients with GIST—Limitations and Opportunities in an Academic Setting

por Falkenhorst, Johanna, Grunewald, Susanne, Krzeciesa, Dawid, Herold, Thomas, Ketzer, Julia, Christoff, Miriam, Hamacher, Rainer, Kostbade, Karina, Treckmann, Jürgen, Köster, Johannes, Farzaliyev, Farhad, Fletcher, Benjamin Samulon, Dieckmann, Nils, Kaths, Moritz, Mühlenberg, Thomas, Schildhaus, Hans-Ulrich, Bauer, Sebastian
Publicado 2022

RNA Sequencing of Human Peripheral Blood Cells Indicates Upregulation of Immune-Related Genes in Huntington's Disease

por Andrade-Navarro, Miguel A., Mühlenberg, Katja, Spruth, Eike J., Mah, Nancy, González-López, Adrián, Andreani, Tommaso, Russ, Jenny, Huska, Matthew R., Muro, Enrique M., Fontaine, Jean-Fred, Amstislavskiy, Vyacheslav, Soldatov, Alexei, Nietfeld, Wilfried, Wanker, Erich E., Priller, Josef
Publicado 2020

Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)

por Heinrich, Michael C., Patterson, Janice, Beadling, Carol, Wang, Yuexiang, Debiec-Rychter, Maria, Dewaele, Barbara, Corless, Christopher L., Duensing, Anette, Raut, Chandrajit P., Rubin, Brian, Ordog, Tamas, van de Rijn, Matt, Call, Jerry, Mühlenberg, Thomas, Fletcher, Jonathan A., Bauer, Sebastian
Publicado 2019

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S

por Lategahn, Jonas, Keul, Marina, Klövekorn, Philip, Tumbrink, Hannah L., Niggenaber, Janina, Müller, Matthias P., Hodson, Luke, Flaßhoff, Maren, Hardick, Julia, Grabe, Tobias, Engel, Julian, Schultz-Fademrecht, Carsten, Baumann, Matthias, Ketzer, Julia, Mühlenberg, Thomas, Hiller, Wolf, Günther, Georgia, Unger, Anke, Müller, Heiko, Heimsoeth, Alena, Golz, Christopher, Blank-Landeshammer, Bernhard, Kollipara, Laxmikanth, Zahedi, René P., Strohmann, Carsten, Hengstler, Jan G., van Otterlo, Willem A. L., Bauer, Sebastian, Rauh, Daniel
Publicado 2019