Comprehensive Analysis of Binding Sites in Tubulin

por Mühlethaler, Tobias, Gioia, Dario, Prota, Andrea E., Sharpe, May E., Cavalli, Andrea, Steinmetz, Michel O.
Publicado 2021

A Structural-Reporter Group to Determine the Core Conformation of Sialyl Lewis(x) Mimetics

por Wagner, Beatrice, Binder, Florian P. C., Jiang, Xiaohua, Mühlethaler, Tobias, Preston, Roland C., Rabbani, Said, Smieško, Martin, Schwardt, Oliver, Ernst, Beat
Publicado 2023

Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action

por Mühlethaler, Tobias, Milanos, Lampros, Ortega, Jose Antonio, Blum, Thorsten B., Gioia, Dario, Roy, Bibhas, Prota, Andrea E., Cavalli, Andrea, Steinmetz, Michel O.
Publicado 2022

Potent neutralization by monoclonal human IgM against SARS‐CoV‐2 is impaired by class switch

por Callegari, Ilaria, Schneider, Mika, Berloffa, Giuliano, Mühlethaler, Tobias, Holdermann, Sebastian, Galli, Edoardo, Roloff, Tim, Boss, Renate, Infanti, Laura, Khanna, Nina, Egli, Adrian, Buser, Andreas, Zimmer, Gert, Derfuss, Tobias, Sanderson, Nicholas S R
Publicado 2022

Structural insight into the stabilization of microtubules by taxanes

por Prota, Andrea E, Lucena-Agell, Daniel, Ma, Yuntao, Estevez-Gallego, Juan, Li, Shuo, Bargsten, Katja, Josa-Prado, Fernando, Altmann, Karl-Heinz, Gaillard, Natacha, Kamimura, Shinji, Mühlethaler, Tobias, Gago, Federico, Oliva, Maria A, Steinmetz, Michel O, Fang, Wei-Shuo, Díaz, J Fernando
Publicado 2023

Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

por Cury, Nathália Moreno, Mühlethaler, Tobias, Laranjeira, Angelo Brunelli Albertoni, Canevarolo, Rafael Renatino, Zenatti, Priscila Pini, Lucena-Agell, Daniel, Barasoain, Isabel, Song, Chunhua, Sun, Dongxiao, Dovat, Sinisa, Yunes, Rosendo Augusto, Prota, Andrea Enrico, Steinmetz, Michel Olivier, Díaz, José Fernando, Yunes, José Andrés
Publicado 2019

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

por Balaguer, Francisco de Asís, Mühlethaler, Tobias, Estévez-Gallego, Juan, Calvo, Enrique, Giménez-Abián, Juan Francisco, Risinger, April L., Sorensen, Erik J., Vanderwal, Christopher D., Altmann, Karl-Heinz, Mooberry, Susan L., Steinmetz, Michel O., Oliva, María Ángela, Prota, Andrea E., Díaz, J. Fernando
Publicado 2019

MAP7 family proteins regulate kinesin-1 recruitment and activation

por Hooikaas, Peter Jan, Martin, Maud, Mühlethaler, Tobias, Kuijntjes, Gert-Jan, Peeters, Cathelijn A.E., Katrukha, Eugene A., Ferrari, Luca, Stucchi, Riccardo, Verhagen, Daan G.F., van Riel, Wilhelmina E., Grigoriev, Ilya, Altelaar, A.F. Maarten, Hoogenraad, Casper C., Rüdiger, Stefan G.D., Steinmetz, Michel O., Kapitein, Lukas C., Akhmanova, Anna
Publicado 2019

Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent

por Jernigan, Finith, Branstrom, Arthur, Baird, John D., Cao, Liangxian, Dali, Mandar, Furia, Bansri, Kim, Min Jung, O'Keefe, Kylie, Kong, Ronald, Laskin, Oscar L., Colacino, Joseph M., Pykett, Mark, Mollin, Anna, Sheedy, Josephine, Dumble, Melissa, Moon, Young-Choon, Sheridan, Richard, Mühlethaler, Tobias, Spiegel, Robert J., Prota, Andrea E., Steinmetz, Michel O., Weetall, Marla
Publicado 2021

Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography

por Wranik, Maximilian, Weinert, Tobias, Slavov, Chavdar, Masini, Tiziana, Furrer, Antonia, Gaillard, Natacha, Gioia, Dario, Ferrarotti, Marco, James, Daniel, Glover, Hannah, Carrillo, Melissa, Kekilli, Demet, Stipp, Robin, Skopintsev, Petr, Brünle, Steffen, Mühlethaler, Tobias, Beale, John, Gashi, Dardan, Nass, Karol, Ozerov, Dmitry, Johnson, Philip J. M., Cirelli, Claudio, Bacellar, Camila, Braun, Markus, Wang, Meitian, Dworkowski, Florian, Milne, Chris, Cavalli, Andrea, Wachtveitl, Josef, Steinmetz, Michel O., Standfuss, Jörg
Publicado 2023