In vitro cytochrome P450‐ and transporter‐mediated drug interaction potential of 6β‐hydroxy‐21‐desacetyl deflazacort—A major human metabolite of deflazacort

por Ma, Jiyuan, Beers, Brian, Manohar, Ravi, Roe, Stephen, Colacino, Joseph M., Kong, Ronald
Publicado 2021

Metabolite V, an epoxide species is a minor circulating metabolite in humans following a single oral dose of deflazacort

por Kong, Ronald, Ma, Jiyuan, Beers, Brian, Kaushik, Diksha, Lin, E, Goodwin, Elizabeth, Colacino, Joseph, Bibbiani, Francesco
Publicado 2020

A Novel Tongue Squamous Cell Carcinoma Cell Line Escapes from Immune Recognition due to Genetic Alterations in HLA Class I Complex

por Zheng, Xiaofeng, Sun, Yanan, Li, Yiwei, Ma, Jiyuan, Lv, Yinan, Hu, Yaying, Zhou, Yi, Zhang, Jiali
Publicado 2022

Ataluren Pharmacokinetics in Healthy Japanese and Caucasian Subjects

por Kong, Ronald, Laskin, Oscar L., Kaushik, Diksha, Jin, Fengbin, Ma, Jiyuan, McIntosh, Joseph, Souza, Marcio, Almstead, Neil
Publicado 2019

LncRNA MALAT1 Regulates miR-144-3p to Facilitate Epithelial-Mesenchymal Transition of Lens Epithelial Cells via the ROS/NRF2/Notch1/Snail Pathway

por Ye, Wei, Ma, Jiyuan, Wang, Fang, Wu, Tong, He, Mengmei, Li, Ji, Pei, Rui, Zhang, Luning, Wang, Yafen, Zhou, Jian
Publicado 2020

The interaction between autophagy and the epithelial-mesenchymal transition mediated by NICD/ULK1 is involved in the formation of diabetic cataracts

por Ma, Jiyuan, Ye, Wei, Yang, Yunshu, Wu, Tong, Wang, Yafen, Li, Ji, Pei, Rui, He, Mengmei, Zhang, Luning, Zhou, Jian
Publicado 2022

A pharmacokinetic drug–drug interaction study between rosuvastatin and emvododstat, a potent anti‐SARS‐CoV‐2 (COVID‐19) DHODH (dihydroorotate dehydrogenase) inhibitor

por Morton, Terri L., Laskin, Oscar L., Kaushik, Diksha, Lee, Lucy, Ma, Jiyuan, Kristensen, Allan, O'Keefe, Kylie, Golden, Lee, Klein, Matthew, Kong, Ronald
Publicado 2023

In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

por Kong, Ronald, Ma, Jiyuan, Hwang, Seongwoo, Moon, Young‐Choon, Welch, Ellen M., Weetall, Marla, Colacino, Joseph M., Almstead, Neil, Babiak, John, Goodwin, Elizabeth
Publicado 2020

First‐in‐Human Studies of Pharmacokinetics and Safety of Utreloxastat (PTC857), a Novel 15‐Lipooxygenase Inhibitor for the Treatment of Amyotrophic Lateral Sclerosis

por Gao, Lan, Giannousis, Peter, Thoolen, Martin, Kaushik, Diksha, Latham, Joey, Tansy, Aaron, Ma, Jiyuan, Johnston, Mayzie, Dali, Mandar, Golden, Lee, Klein, Matthew, Kong, Ronald, Trimmer, Jeffrey
Publicado 2022

A clinical pharmacokinetic drug-drug interaction study between dextromethorphan and emvododstat, a potent anti-SARS-CoV-2 dihydroorotate dehydrogenase inhibitor

por Morton, Terri L., Laskin, Oscar L., Kaushik, Diksha, Lee, Lucy, Ma, Jiyuan, Bar, Cristian M., Kristensen, Allan, O’Keefe, Kylie, Golden, Lee, Klein, Matthew, Kong, Ronald
Publicado 2023