TRP-ing Down the Path to Insulin Secretion

por MacDonald, Patrick E.
Publicado 2011

Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells

por MacDonald, Patrick E, Rorsman, Patrik
Publicado 2006

Novel mouse model expands potential human α-cell research

por dos Santos, Theodore, MacDonald, Patrick E.
Publicado 2021

Glucagon secretion and signaling in the development of diabetes

por Gaisano, Herbert Y., MacDonald, Patrick E., Vranic, Mladen
Publicado 2012

The cell biology of systemic insulin function

por Tokarz, Victoria L., MacDonald, Patrick E., Klip, Amira
Publicado 2018

DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals

por Vergari, Elisa, Plummer, Gregory, Dai, Xiaoqing, MacDonald, Patrick E.
Publicado 2012

Corelease and Differential Exit via the Fusion Pore of GABA, Serotonin, and ATP from LDCV in Rat Pancreatic β Cells

por Braun, Matthias, Wendt, Anna, Karanauskaite, Jovita, Galvanovskis, Juris, Clark, Anne, MacDonald, Patrick E., Rorsman, Patrik
Publicado 2007

A role for PKD1 in insulin secretion downstream of P2Y(1) receptor activation in mouse and human islets

por Khan, Shara, Ferdaoussi, Mourad, Bautista, Austin, Bergeron, Valérie, Smith, Nancy, Poitout, Vincent, MacDonald, Patrick E.
Publicado 2019

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

por Ferdaoussi, Mourad, Fu, Jianyang, Dai, Xiaoqing, Manning Fox, Jocelyn E., Suzuki, Kunimasa, Smith, Nancy, Plummer, Gregory, MacDonald, Patrick E.
Publicado 2017

Modulation of insulin secretion by RBFOX2-mediated alternative splicing

por Moss, Nicole D., Wells, Kristen L., Theis, Alexandra, Kim, Yong-Kyung, Spigelman, Aliya F., Liu, Xiong, MacDonald, Patrick E., Sussel, Lori
Publicado 2023

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

por Dai, Xiao-Qing, Plummer, Greg, Casimir, Marina, Kang, Youhou, Hajmrle, Catherine, Gaisano, Herbert Y., Manning Fox, Jocelyn E., MacDonald, Patrick E.
Publicado 2011

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

por Kolic, Jelena, Manning Fox, Jocelyn E., Chepurny, Oleg G., Spigelman, Aliya F., Ferdaoussi, Mourad, Schwede, Frank, Holz, George G., MacDonald, Patrick E.
Publicado 2016

Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

por Campbell, Scott A., Golec, Dominic P., Hubert, Matt, Johnson, Janyne, Salamon, Nicole, Barr, Amy, MacDonald, Patrick E., Philippaert, Koenraad, Light, Peter E.
Publicado 2020

Impacts of the COVID-19 pandemic on a human research islet program

por Dafoe, Tina J., Dos Santos, Theodore, Spigelman, Aliya F., Lyon, James, Smith, Nancy, Bautista, Austin, MacDonald, Patrick E., Manning Fox, Jocelyn E.
Publicado 2022

A K(ATP) Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans

por MacDonald, Patrick E, Marinis, Yang Zhang De, Ramracheya, Reshma, Salehi, Albert, Ma, Xiaosong, Johnson, Paul R. V, Cox, Roger, Eliasson, Lena, Rorsman, Patrik
Publicado 2007

Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

por Ferdaoussi, Mourad, Smith, Nancy, Lin, Haopeng, Bautista, Austin, Spigelman, Aliya F., Lyon, James, Dai, XiaoQing, Manning Fox, Jocelyn E., MacDonald, Patrick E.
Publicado 2020

Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

por Pigeau, Gary M., Kolic, Jelena, Ball, Brandon J., Hoppa, Michael B., Wang, Ying W., Rückle, Thomas, Woo, Minna, Manning Fox, Jocelyn E., MacDonald, Patrick E.
Publicado 2009

From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science

por Stožer, Andraž, Šterk, Marko, Paradiž Leitgeb, Eva, Markovič, Rene, Skelin Klemen, Maša, Ellis, Cara E., Križančić Bombek, Lidija, Dolenšek, Jurij, MacDonald, Patrick E., Gosak, Marko
Publicado 2022

Yield, cell composition, and function of islets isolated from different ages of neonatal pigs

por Arefanian, Hossein, Ramji, Qahir, Gupta, Nancy, Spigelman, Aliya F., Grynoch, Donald, MacDonald, Patrick E., Mueller, Thomas F., Gazda, Lawrence S., Rajotte, Ray V., Rayat, Gina R.
Publicado 2022

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

por Pepper, Andrew R., Pawlick, Rena, Bruni, Antonio, Wink, John, Rafiei, Yasmin, O’Gorman, Doug, Yan-Do, Richard, Gala-Lopez, Boris, Kin, Tatsuya, MacDonald, Patrick E., Shapiro, A.M. James
Publicado 2017