Disease related single point mutations alter the global dynamics of a tetratricopeptide (TPR) α-solenoid domain

por Llabrés, Salomé, Tsenkov, Maxim I., MacGowan, Stuart A., Barton, Geoffrey J., Zachariae, Ulrich
Publicado 2020

Ankyrin repeats in context with human population variation

por Utgés, Javier S., Tsenkov, Maxim I., Dietrich, Noah J. M., MacGowan, Stuart A., Barton, Geoffrey J.
Publicado 2021

The Dundee Resource for Sequence Analysis and Structure Prediction

por MacGowan, Stuart A., Madeira, Fábio, Britto‐Borges, Thiago, Warowny, Mateusz, Drozdetskiy, Alexey, Procter, James B., Barton, Geoffrey J.
Publicado 2019

Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions o...

por MacGowan, Stuart A., Barton, Michael I., Kutuzov, Mikhail, Dushek, Omer, van der Merwe, P. Anton, Barton, Geoffrey J.
Publicado 2022

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

por Barton, Michael I, MacGowan, Stuart A, Kutuzov, Mikhail A, Dushek, Omer, Barton, Geoffrey John, van der Merwe, P Anton
Publicado 2021

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

por Cleghorn, Laura A. T., Wall, Richard J., Albrecht, Sébastien, MacGowan, Stuart A., Norval, Suzanne, De Rycker, Manu, Woodland, Andrew, Spinks, Daniel, Thompson, Stephen, Patterson, Stephen, Corpas Lopez, Victoriano, Dey, Gourav, Collie, Iain T., Hallyburton, Irene, Kime, Robert, Simeons, Frederick R. C., Stojanovski, Laste, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H., Wyllie, Susan
Publicado 2023