Evidence of uneven selective pressure on different subsets of the conserved human genome; implications for the significance of intronic and intergenic DNA

por Davidson, Scott, Starkey, Andrew, MacKenzie, Alasdair
Publicado 2009

Exploring the effects of polymorphisms on cis-regulatory signal transduction response

por MacKenzie, Alasdair, Hing, Benjamin, Davidson, Scott
Publicado 2013

Understanding the Dynamics of Gene Regulatory Systems; Characterisation and Clinical Relevance of cis-Regulatory Polymorphisms

por Cowie, Philip, Ross, Ruth, MacKenzie, Alasdair
Publicado 2013

Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective?

por McEwan, Andrew R., MacKenzie, Alasdair
Publicado 2020

Using the CRISPR/Cas9 system to understand neuropeptide biology and regulation

por Hay, Elizabeth A., Knowles, Christopher, Kolb, Andreas, MacKenzie, Alasdair
Publicado 2017

Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities

por MacKenzie, Alasdair, Hay, Elizabeth A., McEwan, Andrew R.
Publicado 2022

Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones

por Shanley, Lynne, Lear, Marissa, Davidson, Scott, Ross, Ruth, MacKenzie, Alasdair
Publicado 2011

An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells

por Hay, Colin W., Hunter, Irene, MacKenzie, Alasdair, McEwan, Iain J.
Publicado 2015

A Polymorphism Associated with Depressive Disorders Differentially Regulates Brain Derived Neurotrophic Factor Promoter IV Activity

por Hing, Benjamin, Davidson, Scott, Lear, Marrisa, Breen, Gerome, Quinn, John, McGuffin, Peter, MacKenzie, Alasdair
Publicado 2012

Negative Regulation of the Androgen Receptor Gene Through a Primate-Specific Androgen Response Element Present in the 5′ UTR

por Hay, Colin W., Watt, Kate, Hunter, Irene, Lavery, Derek N., MacKenzie, Alasdair, McEwan, Iain J.
Publicado 2014

An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome

por Hay, Elizabeth Anne, Khalaf, Abdulla Razak, Marini, Pietro, Brown, Andrew, Heath, Karyn, Sheppard, Darrin, MacKenzie, Alasdair
Publicado 2017

Disease‐associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue‐specific activity of the cannabinoid‐1 receptor gene promoter; implications f...

por Hay, Elizabeth A., Cowie, Philip, McEwan, Andrew R., Ross, Ruth, Pertwee, Roger G., MacKenzie, Alasdair
Publicado 2019

Allele-specific Differences in Activity of a Novel Cannabinoid Receptor 1 (CNR1) Gene Intronic Enhancer in Hypothalamus, Dorsal Root Ganglia, and Hippocampus

por Nicoll, Gemma, Davidson, Scott, Shanley, Lynne, Hing, Ben, Lear, Marissa, McGuffin, Peter, Ross, Ruth, MacKenzie, Alasdair
Publicado 2012

M3 Receptor Pathway Stimulates Rapid Transcription of the CB1 Receptor Activation through Calcium Signalling and the CNR1 Gene Promoter

por Marini, Pietro, Cowie, Philip, Ayar, Ahmet, Bewick, Guy S., Barrow, John, Pertwee, Roger G., MacKenzie, Alasdair, Tucci, Paolo
Publicado 2023

Long-Range Regulatory Synergy Is Required to Allow Control of the TAC1 Locus by MEK/ERK Signalling in Sensory Neurones

por Shanley, Lynne, Davidson, Scott, Lear, Marissa, Thotakura, Anil Kumar, McEwan, Iain Joseph, Ross, Ruth A., MacKenzie, Alasdair
Publicado 2011

Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-re...

por Hay, Elizabeth A., McEwan, Andrew, Wilson, Dana, Barrett, Perry, D’Agostino, Giuseppe, Pertwee, Roger G., MacKenzie, Alasdair
Publicado 2019

The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet

por McEwan, Andrew, Erickson, Johanna Celene, Davidson, Connor, Heijkoop, Jenny, Turnbull, Yvonne, Delibegovic, Mirela, Murgatroyd, Christopher, MacKenzie, Alasdair
Publicado 2020

Functional effects of polymorphisms on glucocorticoid receptor modulation of human anxiogenic substance-P gene promoter activity in primary amygdala neurones

por Hay, Colin W., Shanley, Lynne, Davidson, Scott, Cowie, Philip, Lear, Marissa, McGuffin, Peter, Riedel, Gernot, McEwan, Iain J., MacKenzie, Alasdair
Publicado 2014

Discovery and characterization of a thermostable two-domain GH6 endoglucanase from a compost metagenome

por Jensen, Marianne S., Fredriksen, Lasse, MacKenzie, Alasdair K., Pope, Phillip B., Leiros, Ingar, Chylenski, Piotr, Williamson, Adele K., Christopeit, Tony, Østby, Heidi, Vaaje-Kolstad, Gustav, Eijsink, Vincent G. H.
Publicado 2018

Early and reversible changes to the hippocampal proteome in mice on a high-fat diet

por McLean, Fiona H., Campbell, Fiona M., Sergi, Domenico, Grant, Christine, Morris, Amanda C., Hay, Elizabeth A., MacKenzie, Alasdair, Mayer, Claus D., Langston, Rosamund F., Williams, Lynda M.
Publicado 2019