Current and emerging treatment options for spinal muscular atrophy

por Farooq, Faraz, MacKenzie, Alex E
Publicado 2015

A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer

por Cetraro, Pierina, Plaza-Diaz, Julio, MacKenzie, Alex, Abadía-Molina, Francisco
Publicado 2022

Separating the Wheat from the Chaff: The Use of Upstream Regulator Analysis to Identify True Differential Expression of Single Genes within Transcriptomic Datasets

por Hadwen, Jeremiah, Schock, Sarah, Farooq, Faraz, MacKenzie, Alex, Plaza-Diaz, Julio
Publicado 2021

Anisomycin Activates Utrophin Upregulation Through a p38 Signaling Pathway

por Hadwen, Jeremiah, Farooq, Faraz, Witherspoon, Luke, Schock, Sarah, Mongeon, Kevin, MacKenzie, Alex
Publicado 2018

VPAC2 receptor agonist BAY 55-9837 increases SMN protein levels and moderates disease phenotype in severe spinal muscular atrophy mouse models

por Hadwen, Jeremiah, MacKenzie, Duncan, Shamim, Fahad, Mongeon, Kevin, Holcik, Martin, MacKenzie, Alex, Farooq, Faraz
Publicado 2014

Neuronal apoptosis inhibitory protein (NAIP) localizes to the cytokinetic machinery during cell division

por Abadía-Molina, Francisco, Morón-Calvente, Virginia, Baird, Stephen D., Shamim, Fahad, Martín, Francisco, MacKenzie, Alex
Publicado 2017

Mining the transcriptome for rare disease therapies: a comparison of the efficiencies of two data mining approaches and a targeted cell-based drug screen

por Mears, A. J., Schock, S. C., Hadwen, J., Putos, S., Dyment, D., Boycott, K. M., MacKenzie, Alex
Publicado 2017

High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1)

por Neault, Nafisa, O’Reilly, Sean, Baig, Aiman Tariq, Plaza-Diaz, Julio, Azimi, Mehrdad, Farooq, Faraz, Baird, Stephen D., MacKenzie, Alex
Publicado 2021

COVID-19 wastewater surveillance in rural communities: Comparison of lagoon and pumping station samples

por D'Aoust, Patrick M., Towhid, Syeda Tasneem, Mercier, Élisabeth, Hegazy, Nada, Tian, Xin, Bhatnagar, Kamya, Zhang, Zhihao, Naughton, Colleen C., MacKenzie, Alex E., Graber, Tyson E., Delatolla, Robert
Publicado 2021

Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder

por Plaza-Diaz, Julio, Radar, Ana Mei, Baig, Aiman Tariq, Leyba, Marcos Federico, Costabel, Maria Macarena, Zavala-Crichton, Juan Pablo, Sanchez-Martinez, Javier, MacKenzie, Alex E., Solis-Urra, Patricio
Publicado 2022

Vorinostat Improves Myotonic Dystrophy Type 1 Splicing Abnormalities in DM1 Muscle Cell Lines and Skeletal Muscle from a DM1 Mouse Model

por Neault, Nafisa, Ravel-Chapuis, Aymeric, Baird, Stephen D., Lunde, John A., Poirier, Mathieu, Staykov, Emiliyan, Plaza-Diaz, Julio, Medina, Gerardo, Abadía-Molina, Francisco, Jasmin, Bernard J., MacKenzie, Alex E.
Publicado 2023

A generalizable pre-clinical research approach for orphan disease therapy

por Beaulieu, Chandree L, Samuels, Mark E, Ekins, Sean, McMaster, Christopher R, Edwards, Aled M, Krainer, Adrian R, Hicks, Geoffrey G, Frey, Brendan J, Boycott, Kym M, MacKenzie, Alex E
Publicado 2012

Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization

por Morón-Calvente, Virginia, Romero-Pinedo, Salvador, Toribio-Castelló, Sofía, Plaza-Díaz, Julio, Abadía-Molina, Ana C., Rojas-Barros, Domingo I., Beug, Shawn T., LaCasse, Eric C., MacKenzie, Alex, Korneluk, Robert, Abadía-Molina, Francisco
Publicado 2018

Understanding the dynamic relation between wastewater SARS-CoV-2 signal and clinical metrics throughout the pandemic

por Hegazy, Nada, Cowan, Aaron, D'Aoust, Patrick M., Mercier, Élisabeth, Towhid, Syeda Tasneem, Jia, Jian-Jun, Wan, Shen, Zhang, Zhihao, Kabir, Md Pervez, Fang, Wanting, Graber, Tyson E., MacKenzie, Alex E., Guilherme, Stéphanie, Delatolla, Robert
Publicado 2022

Specific combination of compound heterozygous mutations in 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency

por McMillan, Hugh J, Worthylake, Thea, Schwartzentruber, Jeremy, Gottlieb, Chloe C, Lawrence, Sarah E, MacKenzie, Alex, Beaulieu, Chandree L, Mooyer, Petra A W, Wanders, Ronald J A, Majewski, Jacek, Bulman, Dennis E, Geraghty, Michael T, Ferdinandusse, Sacha, Boycott, Kym M
Publicado 2012

Municipal and neighbourhood level wastewater surveillance and subtyping of an influenza virus outbreak

por Mercier, Elisabeth, D’Aoust, Patrick M., Thakali, Ocean, Hegazy, Nada, Jia, Jian-Jun, Zhang, Zhihao, Eid, Walaa, Plaza-Diaz, Julio, Kabir, Md Pervez, Fang, Wanting, Cowan, Aaron, Stephenson, Sean E., Pisharody, Lakshmi, MacKenzie, Alex E., Graber, Tyson E., Wan, Shen, Delatolla, Robert
Publicado 2022

Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency

por Pena, Izabella A., Roussel, Yann, Daniel, Kate, Mongeon, Kevin, Johnstone, Devon, Weinschutz Mendes, Hellen, Bosma, Marjolein, Saxena, Vishal, Lepage, Nathalie, Chakraborty, Pranesh, Dyment, David A., van Karnebeek, Clara D. M., Verhoeven-Duif, Nanda, Bui, Tuan Vu, Boycott, Kym M., Ekker, Marc, MacKenzie, Alex
Publicado 2017

Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalence

por D'Aoust, Patrick M., Mercier, Elisabeth, Montpetit, Danika, Jia, Jian-Jun, Alexandrov, Ilya, Neault, Nafisa, Baig, Aiman Tariq, Mayne, Janice, Zhang, Xu, Alain, Tommy, Langlois, Marc-André, Servos, Mark R., MacKenzie, Malcolm, Figeys, Daniel, MacKenzie, Alex E., Graber, Tyson E., Delatolla, Robert
Publicado 2021

Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 h before COVID-19 clinical tests and 96 h before hospitalizations

por D'Aoust, Patrick M., Graber, Tyson E., Mercier, Elisabeth, Montpetit, Danika, Alexandrov, Ilya, Neault, Nafisa, Baig, Aiman Tariq, Mayne, Janice, Zhang, Xu, Alain, Tommy, Servos, Mark R., Srikanthan, Nivetha, MacKenzie, Malcolm, Figeys, Daniel, Manuel, Douglas, Jüni, Peter, MacKenzie, Alex E., Delatolla, Robert
Publicado 2021

Establishing core outcome sets for phenylketonuria (PKU) and medium-chain Acyl-CoA dehydrogenase (MCAD) deficiency in children: study protocol for systematic reviews and Delphi sur...

por Potter, Beth K., Hutton, Brian, Clifford, Tammy J., Pallone, Nicole, Smith, Maureen, Stockler, Sylvia, Chakraborty, Pranesh, Barbeau, Pauline, Garritty, Chantelle M., Pugliese, Michael, Rahman, Alvi, Skidmore, Becky, Tessier, Laure, Tingley, Kylie, Coyle, Doug, Greenberg, Cheryl R., Korngut, Lawrence, MacKenzie, Alex, Mitchell, John J., Nicholls, Stuart, Offringa, Martin, Schulze, Andreas, Taljaard, Monica
Publicado 2017