Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein

por Nair, Nidhi, Castor, Dennis, Macartney, Thomas, Rouse, John
Publicado 2014

Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3

por Zhang, Jiazhen, Macartney, Thomas, Peggie, Mark, Cohen, Philip
Publicado 2017

IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling

por Dunbar, Karen, Macartney, Thomas J, Sapkota, Gopal P
Publicado 2020

USP11 augments TGFβ signalling by deubiquitylating ALK5

por Al-Salihi, Mazin A., Herhaus, Lina, Macartney, Thomas, Sapkota, Gopal P.
Publicado 2012

OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

por Herhaus, Lina, Al-Salihi, Mazin, Macartney, Thomas, Weidlich, Simone, Sapkota, Gopal P.
Publicado 2013

Critical role of the SPAK protein kinase CCT domain in controlling blood pressure

por Zhang, Jinwei, Siew, Keith, Macartney, Thomas, O'Shaughnessy, Kevin M., Alessi, Dario R.
Publicado 2015

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

por Rojas-Fernandez, Alejandro, Herhaus, Lina, Macartney, Thomas, Lachaud, Christophe, Hay, Ronald T., Sapkota, Gopal P.
Publicado 2015

Targeting endogenous proteins for degradation through the affinity-directed protein missile system

por Fulcher, Luke J., Hutchinson, Luke D., Macartney, Thomas J., Turnbull, Craig, Sapkota, Gopal P.
Publicado 2017

Reconstitution of human CMG helicase ubiquitylation by CUL2(LRR1) and multiple E2 enzymes

por Le, Thanh Thi, Ainsworth, Johanna, Polo Rivera, Cristian, Macartney, Thomas, Labib, Karim P.M.
Publicado 2021

Structural insights into the activation of MST3 by MO25

por Mehellou, Youcef, Alessi, Dario R., Macartney, Thomas J., Szklarz, Marta, Knapp, Stefan, Elkins, Jonathan M.
Publicado 2013

An affinity-directed protein missile system for targeted proteolysis

por Fulcher, Luke J., Macartney, Thomas, Bozatzi, Polyxeni, Hornberger, Annika, Rojas-Fernandez, Alejandro, Sapkota, Gopal P.
Publicado 2016

FAM83F regulates canonical Wnt signalling through an interaction with CK1α

por Dunbar, Karen, Jones, Rebecca A, Dingwell, Kevin, Macartney, Thomas J, Smith, James C, Sapkota, Gopal P
Publicado 2020

Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks

por Malik, Nazma, Macartney, Thomas, Hornberger, Annika, Anderson, Karen E., Tovell, Hannah, Prescott, Alan R., Alessi, Dario R.
Publicado 2018

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

por Vogt, Janis, Dingwell, Kevin S., Herhaus, Lina, Gourlay, Robert, Macartney, Thomas, Campbell, David, Smith, James C., Sapkota, Gopal P.
Publicado 2014

Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader

por Tovell, Hannah, Testa, Andrea, Maniaci, Chiara, Zhou, Houjiang, Prescott, Alan R, Macartney, Thomas, Ciulli, Alessio, Alessi, Dario R
Publicado 2019

Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System

por Röth, Sascha, Macartney, Thomas J., Konopacka, Agnieszka, Chan, Kwok-Ho, Zhou, Houjiang, Queisser, Markus A., Sapkota, Gopal P.
Publicado 2020

USP45 deubiquitylase controls ERCC1–XPF endonuclease-mediated DNA damage responses

por Perez-Oliva, Ana B, Lachaud, Christophe, Szyniarowski, Piotr, Muñoz, Ivan, Macartney, Thomas, Hickson, Ian, Rouse, John, Alessi, Dario R
Publicado 2015

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K(+)–Cl(−) co-transporters

por delos Heros, Paola, Alessi, Dario R., Gourlay, Robert, Campbell, David G., Deak, Maria, Macartney, Thomas J., Kahle, Kristopher T., Zhang, Jinwei
Publicado 2014

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt intera...

por Ohta, Akihito, Schumacher, Frances-Rose, Mehellou, Youcef, Johnson, Clare, Knebel, Axel, Macartney, Thomas J., Wood, Nicola T., Alessi, Dario R., Kurz, Thimo
Publicado 2013

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

por Malik, Nazma, Nirujogi, Raja S., Peltier, Julien, Macartney, Thomas, Wightman, Melanie, Prescott, Alan R., Gourlay, Robert, Trost, Matthias, Alessi, Dario R., Karapetsas, Athanasios
Publicado 2019