Therapeutic Targeting of the IGF Axis

por Osher, Eliot, Macaulay, Valentine M.
Publicado 2019

Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies

por Simpson, Aaron, Petnga, Wilfride, Macaulay, Valentine M., Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas
Publicado 2017

IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits

por Mills, Jack V., Osher, Eliot, Rieunier, Guillaume, Mills, Ian G., Macaulay, Valentine M.
Publicado 2021

RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition

por Earwaker, Philip, Anderson, Caroline, Willenbrock, Frances, Harris, Adrian L., Protheroe, Andrew S., Macaulay, Valentine M.
Publicado 2018

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination

por Chitnis, Meenali M., Lodhia, Kunal A., Aleksic, Tamara, Gao, Shan, Protheroe, Andrew S., Macaulay, Valentine M.
Publicado 2013

Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma

por Simpson, Aaron D., Soo, Ying Wei Jenetta, Rieunier, Guillaume, Aleksic, Tamara, Ansorge, Olaf, Jones, Chris, Macaulay, Valentine M.
Publicado 2019

Obesity: a perfect storm for carcinogenesis

por Harris, Benjamin H. L., Macaulay, Valentine M., Harris, David A., Klenerman, Paul, Karpe, Fredrik, Lord, Simon R., Harris, Adrian L., Buffa, Francesca M.
Publicado 2022

Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR

por Aleksic, Tamara, Browning, Lisa, Woodward, Martha, Phillips, Rachel, Page, Suzanne, Henderson, Shirley, Athanasou, Nicholas, Ansorge, Olaf, Whitwell, Duncan, Pratap, Sarah, Hassan, A. Bassim, Middleton, Mark R., Macaulay, Valentine M.
Publicado 2016

CHK1 inhibition exacerbates replication stress induced by IGF blockade

por Wu, Xiaoning, Seraia, Elena, Hatch, Stephanie B., Wan, Xiao, Ebner, Daniel V., Aroldi, Francesca, Jiang, Yanyan, Ryan, Anderson J., Bogenrieder, Thomas, Weyer-Czernilofsky, Ulrike, Rieunier, Guillaume, Macaulay, Valentine M.
Publicado 2021

WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma

por Coupe, Nicholas, Guo, Lina, Bridges, Esther, Campo, Leticia, Espinosa, Olivia, Colling, Richard, Marshall, Andrea, Nandakumar, Ashwin, van Stiphout, Ruud, Buffa, Francesca M., Corrie, Pippa G., Middleton, Mark R., Macaulay, Valentine M.
Publicado 2022

IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer

por Aleksic, Tamara, Verrill, Clare, Bryant, Richard J, Han, Cheng, Worrall, Andrew Ross, Brureau, Laurent, Larré, Stephane, Higgins, Geoff S, Fazal, Fahad, Sabbagh, Ahmad, Haider, Syed, Buffa, Francesca M, Cole, David, Macaulay, Valentine M
Publicado 2017

A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer

por Macaulay, Valentine M., Lord, Simon, Hussain, Syed, Maroto, José Pablo, Jones, Robert Hugh, Climent, Miguel Ángel, Cook, Natalie, Lin, Chia-Chi, Wang, Shian-Shiang, Bianchini, Diletta, Bailey, Mark, Schlieker, Laura, Bogenrieder, Thomas, de Bono, Johann
Publicado 2023

IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide

por Ramcharan, Roger, Aleksic, Tamara, Kamdoum, Wilfride Petnga, Gao, Shan, Pfister, Sophia X., Tanner, Jordan, Bridges, Esther, Asher, Ruth, Watson, Amanda J., Margison, Geoffrey P., Woodcock, Mick, Repapi, Emmanouela, Li, Ji-Liang, Middleton, Mark R., Macaulay, Valentine M.
Publicado 2015

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

por Pfister, Sophia X., Markkanen, Enni, Jiang, Yanyan, Sarkar, Sovan, Woodcock, Mick, Orlando, Giulia, Mavrommati, Ioanna, Pai, Chen-Chun, Zalmas, Lykourgos-Panagiotis, Drobnitzky, Neele, Dianov, Grigory L., Verrill, Clare, Macaulay, Valentine M., Ying, Songmin, La Thangue, Nicholas B., D’Angiolella, Vincenzo, Ryan, Anderson J., Humphrey, Timothy C.
Publicado 2015