Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans

por Maccecchini, Maria L, Chang, Mee Young, Pan, Catherine, John, Varghese, Zetterberg, Henrik, Greig, Nigel H
Publicado 2012

Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse

por Teich, Andrew F., Sharma, Ekta, Barnwell, Eliza, Zhang, Hong, Staniszewski, Agnieszka, Utsuki, Tadanobu, Padmaraju, Vasudevaraju, Mazell, Cheryl, Tzekou, Apostolia, Sambamurti, Kumar, Arancio, Ottavio, Maccecchini, Maria L.
Publicado 2018

Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression

por Chen, Xu-Qiao, Barrero, Carlos A., Vasquez-Del Carpio, Rodrigo, Reddy, E. Premkumar, Fecchio, Chiara, Merali, Salim, Deglincerti, Alessia, Fang, Cheng, Rogers, Jack, Maccecchini, Maria L.
Publicado 2021