Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo

por Morrish, Emma, Mackiewicz, Liana, Silke, Natasha, Pellegrini, Marc, Silke, John, Brumatti, Gabriela, Ebert, Gregor
Publicado 2020

A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection

por Preston, Simon P., Allison, Cody C., Schaefer, Jan, Clow, William, Bader, Stefanie M., Collard, Sophie, Forsyth, Wasan O., Clark, Michelle P., Garnham, Alexandra L., Li-Wai-Suen, Connie S. N., Peiris, Thanushi, Teale, Jack, Mackiewicz, Liana, Davidson, Sophia, Doerflinger, Marcel, Pellegrini, Marc
Publicado 2023

Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models

por Clark, Michelle P., Huynh, Thao, Rao, Shringar, Mackiewicz, Liana, Mason, Hugh, Romal, Shahla, Stutz, Michael D., Ahn, Sang H., Earnest, Linda, Sozzi, Vitina, Littlejohn, Margaret, Tran, Bang M., Wiedemann, Norbert, Vincan, Elizabeth, Torresi, Joseph, Netter, Hans J., Mahmoudi, Tokameh, Revill, Peter, Pellegrini, Marc, Ebert, Gregor
Publicado 2021

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria

por Bader, Stefanie M., Preston, Simon P., Saliba, Katie, Lipszyc, Adam, Grant, Zoe L., Mackiewicz, Liana, Baldi, Andrew, Hempel, Anne, Clark, Michelle P., Peiris, Thanushi, Clow, William, Bjelic, Jan, Stutz, Michael D., Arandjelovic, Philip, Teale, Jack, Du, Fashuo, Coultas, Leigh, Murphy, James M., Allison, Cody C., Pellegrini, Marc, Samson, Andre L.
Publicado 2022

SARS-CoV-2 mouse adaptation selects virulence mutations that cause TNF-driven age-dependent severe disease with human correlates

por Bader, Stefanie M., Cooney, James P., Sheerin, Dylan, Taiaroa, George, Harty, Leigh, Davidson, Kathryn C., Mackiewicz, Liana, Dayton, Merle, Wilcox, Stephen, Whitehead, Lachlan, Rogers, Kelly L., Georgy, Smitha Rose, Coussens, Anna K., Grimley, Samantha L., Corbin, Vincent, Pitt, Miranda, Coin, Lachlan, Pickering, Raelene, Thomas, Merlin, Allison, Cody C., McAuley, Julie, Purcell, Damian F. J., Doerflinger, Marcel, Pellegrini, Marc
Publicado 2023

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

por Calleja, Dale J., Kuchel, Nathan, Lu, Bernadine G. C., Birkinshaw, Richard W., Klemm, Theresa, Doerflinger, Marcel, Cooney, James P., Mackiewicz, Liana, Au, Amanda E., Yap, Yu Q., Blackmore, Timothy R, Katneni, Kasiram, Crighton, Elly, Newman, Janet, Jarman, Kate E., Call, Melissa J., Lechtenberg, Bernhard C., Czabotar, Peter E., Pellegrini, Marc, Charman, Susan A., Lowes, Kym N., Mitchell, Jeffrey P., Nachbur, Ueli, Lessene, Guillaume, Komander, David
Publicado 2022

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

por Simpson, Daniel S., Pang, Jiyi, Weir, Ashley, Kong, Isabella Y., Fritsch, Melanie, Rashidi, Maryam, Cooney, James P., Davidson, Kathryn C., Speir, Mary, Djajawi, Tirta M., Hughes, Sebastian, Mackiewicz, Liana, Dayton, Merle, Anderton, Holly, Doerflinger, Marcel, Deng, Yexuan, Huang, Allan Shuai, Conos, Stephanie A., Tye, Hazel, Chow, Seong H., Rahman, Arfatur, Norton, Raymond S., Naderer, Thomas, Nicholson, Sandra E., Burgio, Gaetan, Man, Si Ming, Groom, Joanna R., Herold, Marco J., Hawkins, Edwin D., Lawlor, Kate E., Strasser, Andreas, Silke, John, Pellegrini, Marc, Kashkar, Hamid, Feltham, Rebecca, Vince, James E.
Publicado 2022