Targeting the Checkpoint to Kill Cancer Cells

por Benada, Jan, Macurek, Libor
Publicado 2015

Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer

por Medema, René H., Macurek, Libor
Publicado 2011

WIP1 phosphatase as pharmacological target in cancer therapy

por Pecháčková, Soňa, Burdová, Kamila, Macurek, Libor
Publicado 2017

Substrate recognition and function of the R2TP complex in response to cellular stress

por von Morgen, Patrick, Hořejší, Zuzana, Macurek, Libor
Publicado 2015

p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775

por Hauge, Sissel, Macurek, Libor, Syljuåsen, Randi G.
Publicado 2019

WIP1 Promotes Homologous Recombination and Modulates Sensitivity to PARP Inhibitors

por Burdova, Kamila, Storchova, Radka, Palek, Matous, Macurek, Libor
Publicado 2019

Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma

por Martinikova, Andra S., Burocziova, Monika, Stoyanov, Miroslav, Macurek, Libor
Publicado 2020

Polo-like kinase 1 inhibits DNA damage response during mitosis

por Benada, Jan, Burdová, Kamila, Lidak, Tomáš, von Morgen, Patrick, Macurek, Libor
Publicado 2015

Residual Cdk1/2 activity after DNA damage promotes senescence

por Müllers, Erik, Silva Cascales, Helena, Burdova, Kamila, Macurek, Libor, Lindqvist, Arne
Publicado 2017

Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3

por Pechackova, Sona, Burdova, Kamila, Benada, Jan, Kleiblova, Petra, Jenikova, Gabriela, Macurek, Libor
Publicado 2016

Phosphorylation of PLK3 Is Controlled by Protein Phosphatase 6

por Aquino Perez, Cecilia, Palek, Matous, Stolarova, Lenka, von Morgen, Patrick, Macurek, Libor
Publicado 2020

Ppm1d truncating mutations promote the development of genotoxic stress-induced AML

por Burocziova, Monika, Danek, Petr, Oravetzova, Anna, Chalupova, Zuzana, Alberich-Jorda, Meritxell, Macurek, Libor
Publicado 2023

Spatial Separation of Plk1 Phosphorylation and Activity

por Bruinsma, Wytse, Aprelia, Melinda, Kool, Jolanda, Macurek, Libor, Lindqvist, Arne, Medema, René H.
Publicado 2015

DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase

por Brazina, Jan, Svadlenka, Jan, Macurek, Libor, Andera, Ladislav, Hodny, Zdenek, Bartek, Jiri, Hanzlikova, Hana
Publicado 2015

CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate

por Stolarova, Lenka, Kleiblova, Petra, Janatova, Marketa, Soukupova, Jana, Zemankova, Petra, Macurek, Libor, Kleibl, Zdenek
Publicado 2020

Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres

por Storchova, Radka, Palek, Matous, Palkova, Natalie, Veverka, Pavel, Brom, Tomas, Hofr, Ctirad, Macurek, Libor
Publicado 2023

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN Complex

por Otahalova, Barbora, Volkova, Zuzana, Soukupova, Jana, Kleiblova, Petra, Janatova, Marketa, Vocka, Michal, Macurek, Libor, Kleibl, Zdenek
Publicado 2023

Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1

por Silva Cascales, Helena, Burdova, Kamila, Middleton, Anna, Kuzin, Vladislav, Müllers, Erik, Stoy, Henriette, Baranello, Laura, Macurek, Libor, Lindqvist, Arne
Publicado 2021

C53 Interacting with UFM1-Protein Ligase 1 Regulates Microtubule Nucleation in Response to ER Stress

por Klebanovych, Anastasiya, Vinopal, Stanislav, Dráberová, Eduarda, Sládková, Vladimíra, Sulimenko, Tetyana, Sulimenko, Vadym, Vosecká, Věra, Macůrek, Libor, Legido, Agustin, Dráber, Pavel
Publicado 2022

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

por Kleiblova, Petra, Shaltiel, Indra A., Benada, Jan, Ševčík, Jan, Pecháčková, Soňa, Pohlreich, Petr, Voest, Emile E., Dundr, Pavel, Bartek, Jiri, Kleibl, Zdenek, Medema, René H., Macurek, Libor
Publicado 2013