SERIneALanine Killer: SPT promiscuity inhibits tumour growth via intra-tumoral deoxysphingolipid production

por Falcone, Mattia, Maddocks, Oliver D. K.
Publicado 2020

Metabolic regulation by p53

por Maddocks, Oliver D. K., Vousden, Karen H.
Publicado 2011

Erratum to: Metabolic regulation by p53

por Maddocks, Oliver D. K., Vousden, Karen H.
Publicado 2011

One-carbon metabolism in cancer

por Newman, Alice C, Maddocks, Oliver D K
Publicado 2017

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

por Maddocks, Oliver D.K., Labuschagne, Christiaan F., Adams, Peter D., Vousden, Karen H.
Publicado 2016

p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant

por Humpton, Timothy J., Hock, Andreas K., Maddocks, Oliver D. K., Vousden, Karen H.
Publicado 2018

Attaching and Effacing Escherichia coli Downregulate DNA Mismatch Repair Protein In Vitro and Are Associated with Colorectal Adenocarcinomas in Humans

por Maddocks, Oliver D. K., Short, Abigail J., Donnenberg, Michael S., Bader, Scott, Harrison, David J.
Publicado 2009

Metabolic Regulation by p53 Family Members

por Berkers, Celia R., Maddocks, Oliver D.K., Cheung, Eric C., Mor, Inbal, Vousden, Karen H.
Publicado 2013

Polyamine pathway activity promotes cysteine essentiality in cancer cells

por Zhang, Tong, Bauer, Christin, Newman, Alice C., Uribe, Alejandro Huerta, Athineos, Dimitris, Blyth, Karen, Maddocks, Oliver D.K.
Publicado 2020

Serine starvation induces stress and p53 dependent metabolic remodeling in cancer cells

por Maddocks, Oliver D. K., Berkers, Celia R., Mason, Susan M., Zheng, Liang, Blyth, Karen, Gottlieb, Eyal, Vousden, Karen H.
Publicado 2012

A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila

por Scopelliti, Alessandro, Bauer, Christin, Yu, Yachuan, Zhang, Tong, Kruspig, Björn, Murphy, Daniel J., Vidal, Marcos, Maddocks, Oliver D.K., Cordero, Julia B.
Publicado 2019

Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress

por Marx, Christian, Sonnemann, Jürgen, Maddocks, Oliver D. K., Marx-Blümel, Lisa, Beyer, Mandy, Hoelzer, Doerte, Thierbach, René, Maletzki, Claudia, Linnebacher, Michael, Heinzel, Thorsten, Krämer, Oliver H.
Publicado 2022

Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour

por Henriques, Sílvia F., Dhakan, Darshan B., Serra, Lúcia, Francisco, Ana Patrícia, Carvalho-Santos, Zita, Baltazar, Célia, Elias, Ana Paula, Anjos, Margarida, Zhang, Tong, Maddocks, Oliver D. K., Ribeiro, Carlos
Publicado 2020

Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD (+) depletion

por Oakey, Lucy A., Fletcher, Rachel S., Elhassan, Yasir S., Cartwright, David M., Doig, Craig L., Garten, Antje, Thakker, Alpesh, Maddocks, Oliver D. K., Zhang, Tong, Tennant, Daniel A., Ludwig, Christian, Lavery, Gareth G.
Publicado 2019

Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies

por Graham, Charlotte, Stefanatos, Rhoda, Yek, Angeline E. H., Spriggs, Ruth V., Loh, Samantha H. Y., Uribe, Alejandro Huerta, Zhang, Tong, Martins, L. Miguel, Maddocks, Oliver D. K., Scialo, Filippo, Sanz, Alberto
Publicado 2022

Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing

por Carroll, Bernadette, Nelson, Glyn, Rabanal-Ruiz, Yoana, Kucheryavenko, Olena, Dunhill-Turner, Natasha A., Chesterman, Charlotte C., Zahari, Qabil, Zhang, Tong, Conduit, Sarah E., Mitchell, Christina A., Maddocks, Oliver D.K., Lovat, Penny, von Zglinicki, Thomas, Korolchuk, Viktor I.
Publicado 2017

mTORC1 activity is supported by spatial association with focal adhesions

por Rabanal-Ruiz, Yoana, Byron, Adam, Wirth, Alexander, Madsen, Ralitsa, Sedlackova, Lucia, Hewitt, Graeme, Nelson, Glyn, Stingele, Julian, Wills, Jimi C., Zhang, Tong, Zeug, André, Fässler, Reinhard, Vanhaesebroeck, Bart, Maddocks, Oliver D.K., Ponimaskin, Evgeni, Carroll, Bernadette, Korolchuk, Viktor I.
Publicado 2021

Sensitisation of cancer cells to radiotherapy by serine and glycine starvation

por Falcone, Mattia, Uribe, Alejandro Huerta, Papalazarou, Vasileios, Newman, Alice C., Athineos, Dimitris, Stevenson, Katrina, Sauvé, Charles-Etienne Gabriel, Gao, Yajing, Kim, Jin K., Del Latto, Michael, Kierstead, Maria, Wu, Chao, Smith, J. Joshua, Romesser, Paul B., Chalmers, Anthony J., Blyth, Karen, Maddocks, Oliver D. K.
Publicado 2022

Mechanistic insights into p53‐regulated cytotoxicity of combined entinostat and irinotecan against colorectal cancer cells

por Marx, Christian, Sonnemann, Jürgen, Beyer, Mandy, Maddocks, Oliver D. K., Lilla, Sergio, Hauzenberger, Irene, Piée‐Staffa, Andrea, Siniuk, Kanstantsin, Nunna, Suneetha, Marx‐Blümel, Lisa, Westermann, Martin, Wagner, Tobias, Meyer, Felix B., Thierbach, René, Mullins, Christina S., Kdimati, Said, Linnebacher, Michael, Neri, Francesco, Heinzel, Thorsten, Wang, Zhao‐Qi, Krämer, Oliver H.
Publicado 2021

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

por Tajan, Mylène, Hennequart, Marc, Cheung, Eric C., Zani, Fabio, Hock, Andreas K., Legrave, Nathalie, Maddocks, Oliver D. K., Ridgway, Rachel A., Athineos, Dimitris, Suárez-Bonnet, Alejandro, Ludwig, Robert L., Novellasdemunt, Laura, Angelis, Nikolaos, Li, Vivian S. W., Vlachogiannis, Georgios, Valeri, Nicola, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.
Publicado 2021