Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters

por Mateu, Natalia, Kidd, Sarah L., Kalash, Leen, Sore, Hannah F., Madin, Andrew, Bender, Andreas, Spring, David R.
Publicado 2018

Partially Saturated Bicyclic Heteroaromatics as an sp(3)‐Enriched Fragment Collection

por Twigg, David G., Kondo, Noriyasu, Mitchell, Sophie L., Galloway, Warren R. J. D., Sore, Hannah F., Madin, Andrew, Spring, David R.
Publicado 2016

Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries

por Hunter, James H., Anderson, Matthew J., Castan, Isaline F. S. F., Graham, Jessica S., Salvini, Catherine L. A., Stanway-Gordon, Harriet A., Crawford, James J., Madin, Andrew, Pairaudeau, Garry, Waring, Michael J.
Publicado 2021

A small molecule inhibitor of HER3: a proof-of-concept study

por Colomba, Audrey, Fitzek, Martina, George, Roger, Weitsman, Gregory, Roberts, Selene, Zanetti-Domingues, Laura, Hirsch, Michael, Rolfe, Daniel J., Mehmood, Shahid, Madin, Andrew, Claus, Jeroen, Kjaer, Svend, Snijders, Ambrosius P., Ng, Tony, Martin-Fernandez, Marisa, Smith, David M., Parker, Peter J.
Publicado 2020

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition

por Kennedy, Amanda J., Sundström, Linda, Geschwindner, Stefan, Poon, Eunice K. Y., Jiang, Yuhong, Chen, Rongfeng, Cooke, Rob, Johnstone, Shawn, Madin, Andrew, Lim, Junxian, Liu, Qingqi, Lohman, Rink-Jan, Nordqvist, Anneli, Fridén-Saxin, Maria, Yang, Wenzhen, Brown, Dean G., Fairlie, David P., Dekker, Niek
Publicado 2020

Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion

por Kidd, Sarah L., Fowler, Elaine, Reinhardt, Till, Compton, Thomas, Mateu, Natalia, Newman, Hector, Bellini, Dom, Talon, Romain, McLoughlin, Joseph, Krojer, Tobias, Aimon, Anthony, Bradley, Anthony, Fairhead, Michael, Brear, Paul, Díaz-Sáez, Laura, McAuley, Katherine, Sore, Hannah F., Madin, Andrew, O'Donovan, Daniel H., Huber, Kilian V. M., Hyvönen, Marko, von Delft, Frank, Dowson, Christopher G., Spring, David R.
Publicado 2020

A small molecule PI3Kα activator for cardioprotection and neuroregeneration

por Gong, Grace Q, Bilanges, Benoit, Allsop, Ben, Masson, Glenn R, Roberton, Victoria, Askwith, Trevor, Oxenford, Sally, Madsen, Ralitsa R, Conduit, Sarah E, Bellini, Dom, Fitzek, Martina, Collier, Matt, Najam, Osman, He, Zhenhe, Wahab, Ben, McLaughlin, Stephen H, Chan, AW Edith, Feierberg, Isabella, Madin, Andrew, Morelli, Daniele, Bhamra, Amandeep, Vinciauskaite, Vanesa, Anderson, Karen E., Surinova, Silvia, Pinotsis, Nikos, Lopez-Guadamillas, Elena, Wilcox, Matthew, Hooper, Alice, Patel, Chandni, Whitehead, Maria A, Bunney, Tom D, Stephens, Len R, Hawkins, Phillip T, Katan, Matilda, Yellon, Derek M, Davidson, Sean M, Smith, David M, Phillips, James B, Angell, Richard, Williams, Roger L, Vanhaesebroeck, Bart
Publicado 2023