Evidence for biased agonists and antagonists at the endothelin receptors

por Maguire, Janet J.
Publicado 2016

Endothelin Receptors and Their Antagonists()()

por Maguire, Janet J., Davenport, Anthony P.
Publicado 2015

Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

por Yang, Peiran, Maguire, Janet J., Davenport, Anthony P.
Publicado 2015

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

por Zheng, Yue, Humphry, Melanie, Maguire, Janet J., Bennett, Martin R., Clarke, Murray C.H.
Publicado 2013

Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes

por Robinson, Emma L., Alkass, Kanar, Bergmann, Olaf, Maguire, Janet J., Roderick, H. Llewelyn, Davenport, Anthony P.
Publicado 2020

The therapeutic potential of apelin in kidney disease

por Chapman, Fiona A., Nyimanu, Duuamene, Maguire, Janet J., Davenport, Anthony P., Newby, David E., Dhaun, Neeraj
Publicado 2021

Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention

por Abraham, George R., Nyimanu, Duuamene, Kuc, Rhoda E., Maguire, Janet J., Davenport, Anthony P., Hoole, Stephen P.
Publicado 2022

The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro

por Maguire, Janet J., Jones, Katie L., Kuc, Rhoda E., Clarke, Murray C.H., Bennett, Martin R., Davenport, Anthony P.
Publicado 2014

Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands

por Williams, Thomas L., Macrae, Robyn G. C., Kuc, Rhoda E., Brown, Alastair J. H., Maguire, Janet J., Davenport, Anthony P.
Publicado 2023

Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension

por Kuc, Rhoda E., Carlebur, Myrna, Maguire, Janet J., Yang, Peiran, Long, Lu, Toshner, Mark, Morrell, Nicholas W., Davenport, Anthony P.
Publicado 2014

Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor

por Nyimanu, Duuamene, Kuc, Rhoda E., Williams, Thomas L., Bednarek, Maria, Ambery, Philip, Jermutus, Lutz, Maguire, Janet J., Davenport, Anthony P.
Publicado 2019

In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quanti...

por Nyimanu, Duuamene, Kay, Richard G., Kuc, Rhoda E., Brown, Alastair J.H., Gribble, Fiona M., Maguire, Janet J., Davenport, Anthony P.
Publicado 2021

Cardiac action of the first G protein biased small molecule apelin agonist

por Read, Cai, Fitzpatrick, Christopher M., Yang, Peiran, Kuc, Rhoda E., Maguire, Janet J., Glen, Robert C., Foster, Richard E., Davenport, Anthony P.
Publicado 2016

Inotropic Action of the Puberty Hormone Kisspeptin in Rat, Mouse and Human: Cardiovascular Distribution and Characteristics of the Kisspeptin Receptor

por Maguire, Janet J., Kirby, Helen R., Mead, Emma J., Kuc, Rhoda E., d'Anglemont de Tassigny, Xavier, Colledge, William H., Davenport, Anthony P.
Publicado 2011

Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10

por Owen, Nicola E., Nyimanu, Duuamene, Kuc, Rhoda E., Upton, Paul D., Morrell, Nicholas W., Alexander, Graeme J., Maguire, Janet J., Davenport, Anthony P.
Publicado 2021

Endothelin

por Davenport, Anthony P., Hyndman, Kelly A., Dhaun, Neeraj, Southan, Christopher, Kohan, Donald E., Pollock, Jennifer S., Pollock, David M., Webb, David J., Maguire, Janet J.
Publicado 2016

Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist

por Brame, Aimee L., Maguire, Janet J., Yang, Peiran, Dyson, Alex, Torella, Rubben, Cheriyan, Joseph, Singer, Mervyn, Glen, Robert C., Wilkinson, Ian B., Davenport, Anthony P.
Publicado 2015

Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR1), not G‐Protein‐Coupled Receptor 1 (GPR1), in Human and Rat Vasculature

por Kennedy, Amanda J., Yang, Peiran, Read, Cai, Kuc, Rhoda E., Yang, Lucy, Taylor, Emily J. A., Taylor, Colin W., Maguire, Janet J., Davenport, Anthony P.
Publicado 2016

Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites

por Williams, Thomas L., Strachan, Gregory, Macrae, Robyn G. C., Kuc, Rhoda E., Nyimanu, Duuamene, Paterson, Anna L., Sinha, Sanjay, Maguire, Janet J., Davenport, Anthony P.
Publicado 2021

Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function

por Nyimanu, Duuamene, Chapman, Fiona A., Gallacher, Peter J., Kuc, Rhoda E., Williams, Thomas L., Newby, David E., Maguire, Janet J., Davenport, Anthony P., Dhaun, Neeraj
Publicado 2022