ACK1/TNK2 Tyrosine Kinase: Molecular Signaling and Evolving Role in Cancers

por Mahajan, Kiran, Mahajan, Nupam P.
Publicado 2014

Cross talk of tyrosine kinases with the DNA damage signaling pathways

por Mahajan, Kiran, Mahajan, Nupam P.
Publicado 2015

ACK1–AR and AR–HOXB13 signaling axes: epigenetic regulation of lethal prostate cancers

por Kim, Eric H, Cao, Dengfeng, Mahajan, Nupam P, Andriole, Gerald L, Mahajan, Kiran
Publicado 2020

Prostate cancer immunotherapy: Improving clinical outcomes with a multi-pronged approach

por Sridaran, Dhivya, Bradshaw, Elliot, DeSelm, Carl, Pachynski, Russell, Mahajan, Kiran, Mahajan, Nupam P.
Publicado 2023

Blockade of ACK1/TNK2 To Squelch the Survival of Prostate Cancer Stem-like Cells

por Mahajan, Nupam P., Coppola, Domenico, Kim, Jongphil, Lawrence, Harshani R., Lawrence, Nicholas J., Mahajan, Kiran
Publicado 2018

WEE1 epigenetically modulates 5-hmC levels by pY37-H2B dependent regulation of IDH2 gene expression

por Mahajan, Nupam P., Malla, Pavani, Bhagwat, Shambhavi, Sharma, Vasundhara, Sarnaik, Amod, Kim, Jongphil, Pilon-Thomas, Shari, Weber, Jeffery, Mahajan, Kiran
Publicado 2017

TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability

por Chouhan, Surbhi, Sawant, Mithila, Weimholt, Cody, Luo, Jingqin, Sprung, Robert W., Terrado, Mailyn, Mueller, David M., Earp, H. Shelton, Mahajan, Nupam P.
Publicado 2022

The non-receptor tyrosine kinase TNK2/ACK1 is a novel therapeutic target in triple negative breast cancer

por Wu, Xinyan, Saddiq, Muhammad Zahari, Renuse, Santosh, Kelkar, Dhanashree S, Barbhuiya, Mustafa A, Rojas, Pamela L, Stearns, Vered, Gabrielson, Edward, Malla, Pavani, Sukumar, Saraswati, Mahajan, Nupam P, Pandey, Akhilesh
Publicado 2016

Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer

por Nguyen, Thanh, Sridaran, Dhivya, Chouhan, Surbhi, Weimholt, Cody, Wilson, Audrey, Luo, Jingqin, Li, Tiandao, Koomen, John, Fang, Bin, Putluri, Nagireddy, Sreekumar, Arun, Feng, Felix Y., Mahajan, Kiran, Mahajan, Nupam P.
Publicado 2023

Epigenetic reprogramming of cell cycle genes by ACK1 promotes breast cancer resistance to CDK4/6 inhibitor

por Sawant, Mithila, Wilson, Audrey, Sridaran, Dhivya, Mahajan, Kiran, O’Conor, Christopher J., Hagemann, Ian S., Luo, Jingqin, Weimholt, Cody, Li, Tiandao, Roa, Juan Carlos, Pandey, Akhilesh, Wu, Xinyan, Mahajan, Nupam P.
Publicado 2023

Author Correction: Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer

por Nguyen, Thanh, Sridaran, Dhivya, Chouhan, Surbhi, Weimholt, Cody, Wilson, Audrey, Luo, Jingqin, Li, Tiandao, Koomen, John, Fang, Bin, Putluri, Nagireddy, Sreekumar, Arun, Feng, Felix Y., Mahajan, Kiran, Mahajan, Nupam P.
Publicado 2023

Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting

por Sawant, Mithila, Mahajan, Kiran, Renganathan, Arun, Weimholt, Cody, Luo, Jingqin, Kukshal, Vandna, Jez, Joseph M., Jeon, Myung Sik, Zhang, Bo, Li, Tiandao, Fang, Bin, Luo, Yunting, Lawrence, Nicholas J., Lawrence, Harshani R., Feng, Felix Y., Mahajan, Nupam P.
Publicado 2022

Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance

por Sridaran, Dhivya, Chouhan, Surbhi, Mahajan, Kiran, Renganathan, Arun, Weimholt, Cody, Bhagwat, Shambhavi, Reimers, Melissa, Kim, Eric H., Thakur, Manish K., Saeed, Muhammad A., Pachynski, Russell K., Seeliger, Markus A., Miller, W. Todd, Feng, Felix Y., Mahajan, Nupam P.
Publicado 2022

Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation

por Mahajan, Kiran, Coppola, Domenico, Challa, Sridevi, Fang, Bin, Chen, Y. Ann, Zhu, Weiwei, Lopez, Alexis S., Koomen, John, Engelman, Robert W., Rivera, Charlene, Muraoka-Cook, Rebecca S., Cheng, Jin Q., Schönbrunn, Ernst, Sebti, Said M., Earp, H. Shelton, Mahajan, Nupam P.
Publicado 2010

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

por Sjöström, Martin, Zhao, Shuang G., Levy, Samuel, Zhang, Meng, Ning, Yuhong, Shrestha, Raunak, Lundberg, Arian, Herberts, Cameron, Foye, Adam, Aggarwal, Rahul, Hua, Junjie T., Li, Haolong, Bergamaschi, Anna, Maurice-Dror, Corinne, Maheshwari, Ashutosh, Chen, Sujun, Ng, Sarah W.S., Ye, Wenbin, Petricca, Jessica, Fraser, Michael, Chesner, Lisa, Perry, Marc D., Moreno-Rodriguez, Thaidy, Chen, William S., Alumkal, Joshi J., Chou, Jonathan, Morgans, Alicia K., Beer, Tomasz M., Thomas, George V., Gleave, Martin, Lloyd, Paul, Phillips, Tierney, McCarthy, Erin, Haffner, Michael C., Zoubeidi, Amina, Annala, Matti, Reiter, Robert E., Rettig, Matthew B., Witte, Owen N., Fong, Lawrence, Bose, Rohit, Huang, Franklin W., Luo, Jianhua, Bjartell, Anders, Lang, Joshua M., Mahajan, Nupam P., Lara, Primo N., Evans, Christopher P., Tran, Phuoc T., Posadas, Edwin M., He, Chuan, Cui, Xiao-Long, Huang, Jiaoti, Zwart, Wilbert, Gilbert, Luke A., Maher, Christopher A., Boutros, Paul C., Chi, Kim N., Ashworth, Alan, Small, Eric J., He, Housheng H., Wyatt, Alexander W., Quigley, David A., Feng, Felix Y.
Publicado 2022