Macrophages and neutrophils express IFNλs in granulomas from Mycobacterium tuberculosis-infected nonhuman primates

por Talukdar, Priyanka, Junecko, Beth F., Lane, Daniel S., Maiello, Pauline, Mattila, Joshua T.
Publicado 2022

CD4CD8 Double Positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques

por Diedrich, Collin Richard, Gideon, Hannah Priyadarshini, Rutledge, Tara, Baranowski, Tonilynn Marie, Maiello, Pauline, Myers, Amy J., Lin, Philana Ling
Publicado 2019

Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas

por Grant, Nicole L., Kelly, Kristen, Maiello, Pauline, Abbott, Helena, O’Connor, Shelby, Lin, Philana Ling, Scanga, Charles A., Flynn, JoAnne L.
Publicado 2023

Profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure

por Cadena, Anthony M, Ma, Yixuan, Ding, Tao, Bryant, MacKenzie, Maiello, Pauline, Geber, Adam, Lin, Philana Ling, Flynn, JoAnne L, Ghedin, Elodie
Publicado 2018

Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis

por Martin, Constance J., Cadena, Anthony M., Leung, Vivian W., Lin, Philana Ling, Maiello, Pauline, Hicks, Nathan, Chase, Michael R., Flynn, JoAnne L., Fortune, Sarah M.
Publicado 2017

Blood transcriptional correlates of BCG-induced protection against tuberculosis in rhesus macaques

por Liu, Yiran E., Darrah, Patricia A., Zeppa, Joseph J., Kamath, Megha, Laboune, Farida, Douek, Daniel C., Maiello, Pauline, Roederer, Mario, Flynn, JoAnne L., Seder, Robert A., Khatri, Purvesh
Publicado 2023

Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques

por Ganchua, Sharie Keanne C., Cadena, Anthony M., Maiello, Pauline, Gideon, Hannah P., Myers, Amy J., Junecko, Beth F., Klein, Edwin C., Lin, Philana Ling, Mattila, Joshua T., Flynn, JoAnne L.
Publicado 2018

MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection

por Ellis, Amy L., Balgeman, Alexis J., Larson, Erica C., Rodgers, Mark A., Ameel, Cassaundra, Baranowski, Tonilynn, Kannal, Nadean, Maiello, Pauline, Juno, Jennifer A., Scanga, Charles A., O’Connor, Shelby L.
Publicado 2020

T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

por Grant, Nicole L., Maiello, Pauline, Klein, Edwin, Lin, Philana Ling, Borish, H. Jacob, Tomko, Jaime, Frye, L. James, White, Alexander G., Kirschner, Denise E., Mattila, Joshua T., Flynn, JoAnne L.
Publicado 2022

Spontaneous Control of SIV Replication Does Not Prevent T Cell Dysregulation and Bacterial Dissemination in Animals Co-Infected with M. tuberculosis

por Moriarty, Ryan V., Rodgers, Mark A., Ellis, Amy L., Balgeman, Alexis J., Larson, Erica C., Hopkins, Forrest, Chase, Michael R., Maiello, Pauline, Fortune, Sarah M., Scanga, Charles A., O’Connor, Shelby L.
Publicado 2022

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis

por Diedrich, Collin R., Rutledge, Tara, Maiello, Pauline, Baranowski, Tonilynn M., White, Alexander G., Borish, H. Jacob, Karell, Paul, Hopkins, Forrest, Brown, Jessica, Fortune, Sarah M., Flynn, JoAnne L., Ambrose, Zandrea, Lin, Philana Ling
Publicado 2020

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques

por Cadena, Anthony M., Hopkins, Forrest F., Maiello, Pauline, Carey, Allison F., Wong, Eileen A., Martin, Constance J., Gideon, Hannah P., DiFazio, Robert M., Andersen, Peter, Lin, Philana Ling, Fortune, Sarah M., Flynn, JoAnne L.
Publicado 2018

Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization

por Gideon, Hannah Priyadarshini, Phuah, JiaYao, Myers, Amy J., Bryson, Bryan D., Rodgers, Mark A., Coleman, M. Teresa, Maiello, Pauline, Rutledge, Tara, Marino, Simeone, Fortune, Sarah M., Kirschner, Denise E., Lin, Philana Ling, Flynn, JoAnne L.
Publicado 2015

Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens

por Budak, Maral, Cicchese, Joseph M., Maiello, Pauline, Borish, H. Jacob, White, Alexander G., Chishti, Harris B., Tomko, Jaime, Frye, L. James, Fillmore, Daniel, Kracinovsky, Kara, Sakal, Jennifer, Scanga, Charles A., Lin, Philana Ling, Dartois, Véronique, Linderman, Jennifer J., Flynn, JoAnne L., Kirschner, Denise E.
Publicado 2023

Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques

por Darrah, Patricia A., DiFazio, Robert M., Maiello, Pauline, Gideon, Hannah P., Myers, Amy J., Rodgers, Mark A., Hackney, Joshua A., Lindenstrom, Thomas, Evans, Thomas, Scanga, Charles A., Prikhodko, Victor, Andersen, Peter, Lin, Philana Ling, Laddy, Dominick, Roederer, Mario, Seder, Robert A., Flynn, JoAnne L.
Publicado 2019

PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis

por Lin, Philana Ling, Maiello, Pauline, Gideon, Hannah P., Coleman, M. Teresa, Cadena, Anthony M., Rodgers, Mark A., Gregg, Robert, O’Malley, Melanie, Tomko, Jaime, Fillmore, Daniel, Frye, L. James, Rutledge, Tara, DiFazio, Robert M., Janssen, Christopher, Klein, Edwin, Andersen, Peter L., Fortune, Sarah M., Flynn, JoAnne L.
Publicado 2016

Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques

por Winchell, Caylin G., Mishra, Bibhuti B., Phuah, Jia Yao, Saqib, Mohd, Nelson, Samantha J., Maiello, Pauline, Causgrove, Chelsea M., Ameel, Cassaundra L., Stein, Brianne, Borish, H. Jacob, White, Alexander G., Klein, Edwin C., Zimmerman, Matthew D., Dartois, Véronique, Lin, Philana Ling, Sassetti, Christopher M., Flynn, JoAnne L.
Publicado 2020

Host Immunity to Mycobacterium tuberculosis Infection Is Similar in Simian Immunodeficiency Virus (SIV)-Infected, Antiretroviral Therapy-Treated and SIV-Naïve Juvenile Macaques

por Larson, Erica C., Ellis, Amy L., Rodgers, Mark A., Gubernat, Abigail K., Gleim, Janelle L., Moriarty, Ryan V., Balgeman, Alexis J., Menezes, Yonne K., Ameel, Cassaundra L., Fillmore, Daniel J., Pergalske, Skyler M., Juno, Jennifer A., Maiello, Pauline, White, Alexander G., Borish, H. Jacob, Godfrey, Dale I., Kent, Stephen J., Ndhlovu, Lishomwa C., O’Connor, Shelby L., Scanga, Charles A.
Publicado 2023

Prevention of tuberculosis in macaques after intravenous BCG immunization

por Darrah, Patricia A., Zeppa, Joseph J., Maiello, Pauline, Hackney, Joshua A., Wadsworth, Marc H., Hughes, Travis K., Pokkali, Supriya, Swanson, Phillip A., Grant, Nicole L., Rodgers, Mark A., Kamath, Megha, Causgrove, Chelsea M., Laddy, Dominick J., Bonavia, Aurelio, Casimiro, Danilo, Lin, Philana Ling, Klein, Edwin, White, Alexander G., Scanga, Charles A., Shalek, Alex K., Roederer, Mario, Flynn, JoAnne L., Seder, Robert A.
Publicado 2020

Vaccination with intravenous BCG protects macaques with pre-existing SIV infection from tuberculosis

por Larson, Erica C., Ellis-Connell, Amy L., Rodgers, Mark A., Gubernat, Abigail K., Gleim, Janelle L., Moriarty, Ryan V., Balgeman, Alexis J., Ameel, Cassaundra L., Jauro, Solomon, Tomko, Jaime A., Kracinovsky, Kara B., Maiello, Pauline, Borish, H. Jake, White, Alexander G., Klein, Edwin, Bucsan, Allison N., Darrah, Patricia A., Seder, Robert A., Roederer, Mario, Lin, Philana Ling, Flynn, JoAnne L., O’Connor, Shelby L., Scanga, Charles A.
Publicado 2023