Protein homeostasis in the aged and diseased heart

por Mainali, Nirjal, Ayyadevara, Srinivas, Ganne, Akshatha, Shmookler Reis, Robert J., Mehta, Jawahar L.
Publicado 2023

Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Mainali, Nirjal, Atluri, Paavan, Shmookler Reis, Robert J., Ayyadevara, Srinivas
Publicado 2022

Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation

por Bowroju, Suresh K., Mainali, Nirjal, Ayyadevara, Srinivas, Penthala, Narsimha R., Krishnamachari, Sesha, Kakraba, Samuel, Reis, Robert J. Shmookler, Crooks, Peter A.
Publicado 2020

Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs

por Balasubramaniam, Meenakshisundaram, Mainali, Nirjal, Bowroju, Suresh Kuarm, Atluri, Paavan, Penthala, Narsimha Reddy, Ayyadevera, Srinivas, Crooks, Peter A., Shmookler Reis, Robert J.
Publicado 2020

Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan

por Kakraba, Samuel, Ayyadevara, Srinivas, Mainali, Nirjal, Balasubramaniam, Meenakshisundaram, Bowroju, Suresh, Penthala, Narsimha Reddy, Atluri, Ramani, Barger, Steven W., Griffin, Sue T., Crooks, Peter A., Shmookler Reis, Robert J.
Publicado 2023