Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency

por Ponnienselvan, Karthikeyan, Liu, Pengpeng, Nyalile, Thomas, Oikemus, Sarah, Maitland, Stacy A, Lawson, Nathan D, Luban, Jeremy, Wolfe, Scot A
Publicado 2023

Genome-wide detection of CRISPR editing in vivo using GUIDE-tag

por Liang, Shun-Qing, Liu, Pengpeng, Smith, Jordan L., Mintzer, Esther, Maitland, Stacy, Dong, Xiaolong, Yang, Qiyuan, Lee, Jonathan, Haynes, Cole M., Zhu, Lihua Julie, Watts, Jonathan K., Sontheimer, Erik J., Wolfe, Scot A., Xue, Wen
Publicado 2022

Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming

por Tsagkaraki, Emmanouela, Guilherme, Adilson, Nicoloro, Sarah M., Kelly, Mark, Lifshitz, Lawrence M., Wang, Hui, Min, Kyounghee, Rowland, Leslie A., Santos, Kaltinaitis B., Wetoska, Nicole, Friedline, Randall H., Maitland, Stacy A., Chen, Min, Weinstein, Lee S., Wolfe, Scot A., Kim, Jason K., Czech, Michael P.
Publicado 2023

Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo

por Ibraheim, Raed, Tai, Phillip W. L., Mir, Aamir, Javeed, Nida, Wang, Jiaming, Rodríguez, Tomás C., Namkung, Suk, Nelson, Samantha, Khokhar, Eraj Shafiq, Mintzer, Esther, Maitland, Stacy, Chen, Zexiang, Cao, Yueying, Tsagkaraki, Emmanouela, Wolfe, Scot A., Wang, Dan, Pai, Athma A., Xue, Wen, Gao, Guangping, Sontheimer, Erik J.
Publicado 2021

Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation

por Essawi, Khaled, Hakami, Waleed, Naeem Khan, Muhammad Behroz, Martin, Reid, Zeng, Jing, Chu, Rebecca, Uchida, Naoya, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Donahue, Robert E., Blobel, Gerd A., Gerdemann, Ulrike, Kean, Leslie S., Maitland, Stacy A., Wolfe, Scot A., Metais, Jean-Yves, Gottschalk, Stephen, Bauer, Daniel E., Tisdale, John F., Demirci, Selami
Publicado 2023

CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

por Tsagkaraki, Emmanouela, Nicoloro, Sarah M., DeSouza, Tiffany, Solivan-Rivera, Javier, Desai, Anand, Lifshitz, Lawrence M., Shen, Yuefei, Kelly, Mark, Guilherme, Adilson, Henriques, Felipe, Amrani, Nadia, Ibraheim, Raed, Rodriguez, Tomas C., Luk, Kevin, Maitland, Stacy, Friedline, Randall H., Tauer, Lauren, Hu, Xiaodi, Kim, Jason K., Wolfe, Scot A., Sontheimer, Erik J., Corvera, Silvia, Czech, Michael P.
Publicado 2021