Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine

por Del Coco, Laura, Majellaro, Maria, Boccarelli, Angelina, Cellamare, Saverio, Altomare, Cosimo Damiano, Fanizzi, Francesco Paolo
Publicado 2020

Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors

por Jespers, Willem, Oliveira, Ana, Prieto-Díaz, Rubén, Majellaro, María, Åqvist, Johan, Sotelo, Eddy, Gutiérrez-de-Terán, Hugo
Publicado 2017

Fluorescence based HTS-compatible ligand binding assays for dopamine D(3) receptors in baculovirus preparations and live cells

por Tahk, Maris-Johanna, Laasfeld, Tõnis, Meriste, Elo, Brea, Jose, Loza, Maria Isabel, Majellaro, Maria, Contino, Marialessandra, Sotelo, Eddy, Rinken, Ago
Publicado 2023

Identification of V6.51L as a selectivity hotspot in stereoselective A(2B) adenosine receptor antagonist recognition

por Wang, Xuesong, Jespers, Willem, Prieto-Díaz, Rubén, Majellaro, Maria, IJzerman, Adriaan P., van Westen, Gerard J. P., Sotelo, Eddy, Heitman, Laura H., Gutiérrez-de-Terán, Hugo
Publicado 2021

Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-...

por Abatematteo, Francesca Serena, Majellaro, Maria, Montsch, Bianca, Prieto-Díaz, Rubén, Niso, Mauro, Contino, Marialessandra, Stefanachi, Angela, Riganti, Chiara, Mangiatordi, Giuseppe Felice, Delre, Pietro, Heffeter, Petra, Sotelo, Eddy, Abate, Carmen
Publicado 2023

Potent and Subtype-Selective Dopamine D(2) Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach

por Mallo-Abreu, Ana, Reyes-Resina, Irene, Azuaje, Jhonny, Franco, Rafael, García-Rey, Aitor, Majellaro, Maria, Miranda-Pastoriza, Darío, García-Mera, Xerardo, Jespers, Willem, Gutiérrez-de-Terán, Hugo, Navarro, Gemma, Sotelo, Eddy
Publicado 2021

X‐Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A(2A) Adenosine Receptor Antagonists

por Jespers, Willem, Verdon, Grégory, Azuaje, Jhonny, Majellaro, Maria, Keränen, Henrik, García‐Mera, Xerardo, Congreve, Miles, Deflorian, Francesca, de Graaf, Chris, Zhukov, Andrei, Doré, Andrew S., Mason, Jonathan S., Åqvist, Johan, Cooke, Robert M., Sotelo, Eddy, Gutiérrez‐de‐Terán, Hugo
Publicado 2020

Exploring Non-orthosteric Interactions with a Series of Potent and Selective A(3) Antagonists

por Miranda-Pastoriza, Darío, Bernárdez, Rodrigo, Azuaje, Jhonny, Prieto-Díaz, Rubén, Majellaro, Maria, Tamhankar, Ashish V., Koenekoop, Lucien, González, Alejandro, Gioé-Gallo, Claudia, Mallo-Abreu, Ana, Brea, José, Loza, M. Isabel, García-Rey, Aitor, García-Mera, Xerardo, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Publicado 2022

Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A(1) Antagonists

por Val, Cristina, Rodríguez-García, Carlos, Prieto-Díaz, Rubén, Crespo, Abel, Azuaje, Jhonny, Carbajales, Carlos, Majellaro, Maria, Díaz-Holguín, Alejandro, Brea, José M., Loza, Maria Isabel, Gioé-Gallo, Claudia, Contino, Marialessandra, Stefanachi, Angela, García-Mera, Xerardo, Estévez, Juan C., Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Publicado 2022

A(2B) adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models

por Tay, Apple Hui Min, Prieto-Díaz, Rubén, Neo, Shiyong, Tong, Le, Chen, Xinsong, Carannante, Valentina, Önfelt, Björn, Hartman, Johan, Haglund, Felix, Majellaro, Maria, Azuaje, Jhonny, Garcia-Mera, Xerardo, Brea, Jose M, Loza, Maria I, Jespers, Willem, Gutierrez-de-Teran, Hugo, Sotelo, Eddy, Lundqvist, Andreas
Publicado 2022

Exploring the Effect of Halogenation in a Series of Potent and Selective A(2B) Adenosine Receptor Antagonists

por Prieto-Díaz, Rubén, González-Gómez, Manuel, Fojo-Carballo, Hugo, Azuaje, Jhonny, El Maatougui, Abdelaziz, Majellaro, Maria, Loza, María I., Brea, José, Fernández-Dueñas, Víctor, Paleo, M. Rita, Díaz-Holguín, Alejandro, Garcia-Pinel, Beatriz, Mallo-Abreu, Ana, Estévez, Juan C., Andújar-Arias, Antonio, García-Mera, Xerardo, Gomez-Tourino, Iria, Ciruela, Francisco, Salas, Cristian O., Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Publicado 2022