HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function

por Richardson, Simone I., Ayres, Frances, Manamela, Nelia P., Oosthuysen, Brent, Makhado, Zanele, Lambson, Bronwen E., Morris, Lynn, Moore, Penny L.
Publicado 2021

Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

por Moyo-Gwete, Thandeka, Scheepers, Cathrine, Makhado, Zanele, Kgagudi, Prudence, Mzindle, Nonkululeko B., Ziki, Rutendo, Madzorera, Sharon, Manamela, Nelia P., Ayres, Frances, Lambson, Bronwen E., Richardson, Simone I., Morris, Lynn, Moore, Penny L.
Publicado 2022

Despite delayed kinetics, people living with HIV achieve equivalent antibody function after SARS-CoV-2 infection or vaccination

por Motsoeneng, Boitumelo M., Manamela, Nelia P., Kaldine, Haajira, Kgagudi, Prudence, Hermanus, Tandile, Ayres, Frances, Makhado, Zanele, Moyo-Gwete, Thandeka, van der Mescht, Mieke A., Abdullah, Fareed, Boswell, Michael T., Ueckermann, Veronica, Rossouw, Theresa M., Madhi, Shabir A., Moore, Penny L., Richardson, Simone I.
Publicado 2023

SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity

por Richardson, Simone I., Manamela, Nelia P., Motsoeneng, Boitumelo M., Kaldine, Haajira, Ayres, Frances, Makhado, Zanele, Mennen, Mathilda, Skelem, Sango, Williams, Noleen, Sullivan, Nancy J., Misasi, John, Gray, Glenda G., Bekker, Linda-Gail, Ueckermann, Veronica, Rossouw, Theresa M., Boswell, Michael T., Ntusi, Ntobeko A.B., Burgers, Wendy A., Moore, Penny L.
Publicado 2022

SARS-CoV-2 exposure in Malawian blood donors: an analysis of seroprevalence and variant dynamics between January 2020 and July 2021

por Mandolo, Jonathan, Msefula, Jacquline, Henrion, Marc Y. R., Brown, Comfort, Moyo, Brewster, Samon, Aubrey, Moyo-Gwete, Thandeka, Makhado, Zanele, Ayres, Frances, Motlou, Thopisang, Mzindle, Nonkululeko, Kalata, Newton, Muula, Adamson S., Kwatra, Gaurav, Nsamala, Natasha, Likaka, Andrew, Mfune, Thom, Moore, Penny L., Mbaya, Bridon, French, Neil, Heyderman, Robert S., Swarthout, Todd, Jambo, Kondwani C.
Publicado 2021

Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants

por Moyo-Gwete, Thandeka, Madzivhandila, Mashudu, Mkhize, Nonhlanhla N., Kgagudi, Prudence, Ayres, Frances, Lambson, Bronwen E., Manamela, Nelia P., Richardson, Simone I., Makhado, Zanele, van der Mescht, Mieke A., de Beer, Zelda, de Villiers, Talita Roma, Burgers, Wendy A., Ntusi, Ntobeko A. B., Rossouw, Theresa, Ueckermann, Veronica, Boswell, Michael T., Moore, Penny L.
Publicado 2022

Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection

por Moyo-Gwete, Thandeka, Richardson, Simone I., Keeton, Roanne, Hermanus, Tandile, Spencer, Holly, Manamela, Nelia P., Ayres, Frances, Makhado, Zanele, Motlou, Thopisang, Tincho, Marius B., Benede, Ntombi, Ngomti, Amkele, Baguma, Richard, Chauke, Masego V., Mennen, Mathilda, Adriaanse, Marguerite, Skelem, Sango, Goga, Ameena, Garrett, Nigel, Bekker, Linda-Gail, Gray, Glenda, Ntusi, Ntobeko A.B., Riou, Catherine, Burgers, Wendy A., Moore, Penny L.
Publicado 2023

Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells

por Krause, Robert G. E., Moyo-Gwete, Thandeka, Richardson, Simone I., Makhado, Zanele, Manamela, Nelia P., Hermanus, Tandile, Mkhize, Nonhlanhla N., Keeton, Roanne, Benede, Ntombi, Mennen, Mathilda, Skelem, Sango, Karim, Farina, Khan, Khadija, Riou, Catherine, Ntusi, Ntobeko A. B., Goga, Ameena, Gray, Glenda, Hanekom, Willem, Garrett, Nigel, Bekker, Linda-Gail, Groll, Andreas, Sigal, Alex, Moore, Penny L., Burgers, Wendy A., Leslie, Alasdair
Publicado 2023

Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection

por Moyo-Gwete, Thandeka, Richardson, Simone I., Keeton, Roanne, Hermanus, Tandile, Spencer, Holly, Manamela, Nelia P., Ayres, Frances, Makhado, Zanele, Motlou, Thopisang, Tincho, Marius B., Benede, Ntombi, Ngomti, Amkele, Baguma, Richard, Chauke, Masego V., Mennen, Mathilda, Adriaanse, Marguerite, Skelem, Sango, Goga, Ameena, Garrett, Nigel, Bekker, Linda-Gail, Gray, Glenda, Ntusi, Ntobeko A. B., Riou, Catherine, Burgers, Wendy A., Moore, Penny L.
Publicado 2023

SARS-CoV-2 501Y.V2 (B.1.351) elicits cross-reactive neutralizing antibodies

por Moyo-Gwete, Thandeka, Madzivhandila, Mashudu, Makhado, Zanele, Ayres, Frances, Mhlanga, Donald, Oosthuysen, Brent, Lambson, Bronwen E., Kgagudi, Prudence, Tegally, Houriiyah, Iranzadeh, Arash, Doolabh, Deelan, Tyers, Lynn, Chinhoyi, Lionel R., Mennen, Mathilda, Skelem, Sango, Marais, Gert, Wibmer, Constantinos Kurt, Bhiman, Jinal N, Ueckermann, Veronica, Rossouw, Theresa, Boswell, Michael, de Oliveira, Tulio, Williamson, Carolyn, Burgers, Wendy A, Ntusi, Ntobeko, Morris, Lynn, Moore, Penny L
Publicado 2021

Cross-Reactive Neutralizing Antibody Responses Elicited by SARS-CoV-2 501Y.V2 (B.1.351)

por Moyo-Gwete, Thandeka, Madzivhandila, Mashudu, Makhado, Zanele, Ayres, Frances, Mhlanga, Donald, Oosthuysen, Brent, Lambson, Bronwen E., Kgagudi, Prudence, Tegally, Houriiyah, Iranzadeh, Arash, Doolabh, Deelan, Tyers, Lynn, Chinhoyi, Lionel R., Mennen, Mathilda, Skelem, Sango, Marais, Gert, Wibmer, Constantinos K., Bhiman, Jinal N., Ueckermann, Veronica, Rossouw, Theresa, Boswell, Michael, de Oliveira, Tulio, Williamson, Carolyn, Burgers, Wendy A., Ntusi, Ntobeko, Morris, Lynn, Moore, Penny L.
Publicado 2021

Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern

por Kitchin, Dale, Richardson, Simone I., van der Mescht, Mieke A., Motlou, Thopisang, Mzindle, Nonkululeko, Moyo-Gwete, Thandeka, Makhado, Zanele, Ayres, Frances, Manamela, Nelia P., Spencer, Holly, Lambson, Bronwen, Oosthuysen, Brent, Kaldine, Haajira, du Pisanie, Marizane, Mennen, Mathilda, Skelem, Sango, Williams, Noleen, Ntusi, Ntobeko A.B., Burgers, Wendy A., Gray, Glenda G., Bekker, Linda-Gail, Boswell, Michael T., Rossouw, Theresa M., Ueckermann, Veronica, Moore, Penny L.
Publicado 2022

SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals

por Richardson, Simone I., Madzorera, Vimbai Sharon, Spencer, Holly, Manamela, Nelia P., van der Mescht, Mieke A., Lambson, Bronwen E., Oosthuysen, Brent, Ayres, Frances, Makhado, Zanele, Moyo-Gwete, Thandeka, Mzindle, Nonkululeko, Motlou, Thopisang, Strydom, Amy, Mendes, Adriano, Tegally, Houriiyah, de Beer, Zelda, Roma de Villiers, Talita, Bodenstein, Annie, van den Berg, Gretha, Venter, Marietjie, de Oliviera, Tulio, Ueckermann, Veronica, Rossouw, Theresa M., Boswell, Michael T., Moore, Penny L.
Publicado 2022

Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner

por Keeton, Roanne, Richardson, Simone I., Moyo-Gwete, Thandeka, Hermanus, Tandile, Tincho, Marius B., Benede, Ntombi, Manamela, Nelia P., Baguma, Richard, Makhado, Zanele, Ngomti, Amkele, Motlou, Thopisang, Mennen, Mathilda, Chinhoyi, Lionel, Skelem, Sango, Maboreke, Hazel, Doolabh, Deelan, Iranzadeh, Arash, Otter, Ashley D., Brooks, Tim, Noursadeghi, Mahdad, Moon, James C., Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Blackburn, Jonathan, Hsiao, Nei-Yuan, Williamson, Carolyn, Riou, Catherine, Goga, Ameena, Garrett, Nigel, Bekker, Linda-Gail, Gray, Glenda, Ntusi, Ntobeko A.B., Moore, Penny L., Burgers, Wendy A.
Publicado 2021