Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods

por Makowski, Emily K., Wu, Lina, Gupta, Priyanka, Tessier, Peter M.
Publicado 2021

Highly sensitive detection of antibody nonspecific interactions using flow cytometry

por Makowski, Emily K., Wu, Lina, Desai, Alec A., Tessier, Peter M.
Publicado 2021

Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape

por Makowski, Emily K., Schardt, John S., Smith, Matthew D., Tessier, Peter M.
Publicado 2022

Position-Specific Enrichment Ratio Matrix scores predict antibody variant properties from deep sequencing data

por Smith, Matthew D, Case, Marshall A, Makowski, Emily K, Tessier, Peter M
Publicado 2023

Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates

por Zupancic, Jennifer M., Smith, Matthew D., Trzeciakiewicz, Hanna, Skinner, Mary E., Ferris, Sean P., Makowski, Emily K., Lucas, Michael J., McArthur, Nikki, Kane, Ravi S., Paulson, Henry L., Tessier, Peter M.
Publicado 2023

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

por Makowski, Emily K., Kinnunen, Patrick C., Huang, Jie, Wu, Lina, Smith, Matthew D., Wang, Tiexin, Desai, Alec A., Streu, Craig N., Zhang, Yulei, Zupancic, Jennifer M., Schardt, John S., Linderman, Jennifer J., Tessier, Peter M.
Publicado 2022

Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis

por Zupancic, Jennifer M., Desai, Alec A., Schardt, John S., Pornnoppadol, Ghasidit, Makowski, Emily K., Smith, Matthew D., Kennedy, Andrew A., Garcia de Mattos Barbosa, Mayara, Cascalho, Marilia, Lanigan, Thomas M., Tai, Andrew W., Tessier, Peter M.
Publicado 2021

Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening

por Schardt, John S., Pornnoppadol, Ghasidit, Desai, Alec A., Park, Kyung Soo, Zupancic, Jennifer M., Makowski, Emily K., Smith, Matthew D., Chen, Hongwei, Garcia de Mattos Barbosa, Mayara, Cascalho, Marilia, Lanigan, Thomas M., Moon, James J., Tessier, Peter M.
Publicado 2021

Reduction of therapeutic antibody self-association using yeast-display selections and machine learning

por Makowski, Emily K., Chen, Hongwei, Lambert, Matthew, Bennett, Eric M., Eschmann, Nicole S., Zhang, Yulei, Zupancic, Jennifer M., Desai, Alec A., Smith, Matthew D., Lou, Wenjia, Fernando, Amendra, Tully, Timothy, Gallo, Christopher J., Lin, Laura, Tessier, Peter M.
Publicado 2022

Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity

por Desai, Alec A., Smith, Matthew D., Zhang, Yulei, Makowski, Emily K., Gerson, Julia E., Ionescu, Edward, Starr, Charles G., Zupancic, Jennifer M., Moore, Shannon J., Sutter, Alexandra B., Ivanova, Magdalena I., Murphy, Geoffrey G., Paulson, Henry L., Tessier, Peter M.
Publicado 2021