Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

por Laurent, Anouchka P., Kotecha, Rishi S., Malinge, Sébastien
Publicado 2020

Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia

por Hughes, Anastasia M., Kuek, Vincent, Oommen, Joyce, Chua, Grace-Alyssa, van Loenhout, Maria, Malinge, Sebastien, Kotecha, Rishi S., Cheung, Laurence C.
Publicado 2023

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

por Thompson, Benjamin J., Bhansali, Rahul, Diebold, Lauren, Cook, Daniel E., Stolzenburg, Lindsay, Casagrande, Anne-Sophie, Besson, Thierry, Leblond, Bertrand, Désiré, Laurent, Malinge, Sébastien, Crispino, John D.
Publicado 2015

The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

por Anderson, Denise, Skut, Patrycja, Hughes, Anastasia M., Ferrari, Emanuela, Tickner, Jennifer, Xu, Jiake, Mullin, Benjamin H., Tang, Dave, Malinge, Sébastien, Kees, Ursula R., Kotecha, Rishi S., Lassmann, Timo, Cheung, Laurence C.
Publicado 2020

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

por Ansó, Elena, Weinberg, Samuel E., Diebold, Lauren P., Thompson, Benjamin J., Malinge, Sébastien, Schumacker, Paul T., Liu, Xin, Zhang, Yuannyu, Shao, Zhen, Steadman, Mya, Marsh, Kelly M., Xu, Jian, Crispino, John D., Chandel, Navdeep S.
Publicado 2017

Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia

por Cheung, Laurence C., de Kraa, Rebecca, Oommen, Joyce, Chua, Grace-Alyssa, Singh, Sajla, Hughes, Anastasia M., Ferrari, Emanuela, Ford, Jette, Chiu, Sung K., Stam, Ronald W., Kees, Ursula R., Malinge, Sébastien, Kotecha, Rishi S.
Publicado 2021

Down syndrome and leukemia: from basic mechanisms to clinical advances

por Baruchel, André, Bourquin, Jean-Pierre, Crispino, John, Cuartero, Sergi, Hasle, Henrik, Hitzler, Johann, Klusmann, Jan-Henning, Izraeli, Shai, Lane, Andrew A., Malinge, Sébastien, Rabin, Karen R., Roberts, Irene, Ryeom, Sandra, Tasian, Sarah K., Wagenblast, Elvin
Publicado 2023

Targeting megakaryocytic induced fibrosis by AURKA inhibition in the myeloproliferative neoplasms

por Wen, Qiang Jeremy, Yang, Qiong, Goldenson, Benjamin, Malinge, Sébastien, Lasho, Terra, Schneider, Rebekka K., Breyfogle, Lawrence J., Schultz, Rachael, Gilles, Laure, Koppikar, Priya, Abdel-Wahab, Omar, Pardanani, Animesh, Stein, Brady, Gurbuxani, Sandeep, Mullally, Ann, Levine, Ross, Tefferi, Ayalew, Crispino, John D.
Publicado 2015

Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model

por Arkoun, Brahim, Robert, Elie, Boudia, Fabien, Mazzi, Stefania, Dufour, Virginie, Siret, Aurélie, Mammasse, Yasmine, Aid, Zakia, Vieira, Matthieu, Imanci, Aygun, Aglave, Marine, Cambot, Marie, Petermann, Rachel, Souquere, Sylvie, Rameau, Philippe, Catelain, Cyril, Diot, Romain, Tachdjian, Gérard, Hermine, Olivier, Droin, Nathalie, Debili, Najet, Plo, Isabelle, Malinge, Sébastien, Soler, Eric, Raslova, Hana, Mercher, Thomas, Vainchenker, William
Publicado 2022

Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy

por Cheung, Laurence C., Aya-Bonilla, Carlos, Cruickshank, Mark N., Chiu, Sung K., Kuek, Vincent, Anderson, Denise, Chua, Grace-Alyssa, Singh, Sajla, Oommen, Joyce, Ferrari, Emanuela, Hughes, Anastasia M., Ford, Jette, Kunold, Elena, Hesselman, Maria C., Post, Frederik, Faulk, Kelly E., Breese, Erin H., Guest, Erin M., Brown, Patrick A., Loh, Mignon L., Lock, Richard B., Kees, Ursula R., Jafari, Rozbeh, Malinge, Sébastien, Kotecha, Rishi S.
Publicado 2022

A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors

por Marques Da Costa, Maria Eugénia, Zaidi, Sakina, Scoazec, Jean-Yves, Droit, Robin, Lim, Wan Ching, Marchais, Antonin, Salmon, Jerome, Cherkaoui, Sarah, Morscher, Raphael J., Laurent, Anouchka, Malinge, Sébastien, Mercher, Thomas, Tabone-Eglinger, Séverine, Goddard, Isabelle, Pflumio, Francoise, Calvo, Julien, Redini, Francoise, Entz-Werlé, Natacha, Soriano, Aroa, Villanueva, Alberto, Cairo, Stefano, Chastagner, Pascal, Moro, Massimo, Owens, Cormac, Casanova, Michela, Hladun-Alvaro, Raquel, Berlanga, Pablo, Daudigeos-Dubus, Estelle, Dessen, Philippe, Zitvogel, Laurence, Lacroix, Ludovic, Pierron, Gaelle, Delattre, Olivier, Schleiermacher, Gudrun, Surdez, Didier, Geoerger, Birgit
Publicado 2023

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 lysine 27 trimethylation

por Lane, Andrew A., Chapuy, Bjoern, Lin, Charles Y., Tivey, Trevor, Li, Hubo, Townsend, Elizabeth C., van Bodegom, Diederik, Day, Tovah A., Wu, Shuo-Chieh, Liu, Huiyun, Yoda, Akinori, Alexe, Gabriela, Schinzel, Anna C., Sullivan, Timothy J., Malinge, Sébastien, Taylor, Jordan E., Stegmaier, Kimberly, Jaffe, Jacob D., Bustin, Michael, te Kronnie, Geertruy, Izraeli, Shai, Harris, Marian, Stevenson, Kristen E., Neuberg, Donna, Silverman, Lewis B., Sallan, Stephen E., Bradner, James E., Hahn, William C., Crispino, John D., Pellman, David, Weinstock, David M.
Publicado 2014