Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase

por Choi, Eungi, Mallareddy, Jayapal Reddy, Lu, Dai, Kolluru, Srikanth
Publicado 2018

Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase

por Rana, Sandeep, Mallareddy, Jayapal Reddy, Singh, Sarbjit, Boghean, Lidia, Natarajan, Amarnath
Publicado 2021

Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery

por Kolluru, Srikanth, Momoh, Rosemary, Lin, Lydia, Mallareddy, Jayapal Reddy, Krstenansky, John L.
Publicado 2019

Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA

por Kour, Smit, Rana, Sandeep, Kizhake, Smitha, Lagundžin, Dragana, Klinkebiel, David, Mallareddy, Jayapal Reddy, Huxford, Tom, Woods, Nicholas T., Natarajan, Amarnath
Publicado 2021

Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior

por Umfress, Alan, Singh, Sarbjit, Ryan, Kevin J., Chakraborti, Ayanabha, Plattner, Florian, Sonawane, Yogesh, Mallareddy, Jayapal Reddy, Acosta, Edward P., Natarajan, Amarnath, Bibb, James A.
Publicado 2022

Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells

por Kour, Smit, Rana, Sandeep, Kubica, Sydney P., Kizhake, Smitha, Ahmad, Mudassier, Muñoz-Trujillo, Catalina, Klinkebiel, David, Singh, Sarbjit, Mallareddy, Jayapal Reddy, Chandra, Surabhi, Woods, Nicholas T., Karpf, Adam R., Natarajan, Amarnath
Publicado 2022

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

por Mullen, Nicholas J., Shukla, Surendra K., Thakur, Ravi, Kollala, Sai Sundeep, Wang, Dezhen, Chaika, Nina, LaBreck, Drew A., Mallareddy, Jayapal Reddy, Price, David H., Natarajan, Amarnath, Mehla, Kamiya, Sykes, David B., Hollingsworth, Michael A., Singh, Pankaj K.
Publicado 2023

Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth

por Napoleon, John Victor, Sagar, Satish, Kubica, Sydney P., Boghean, Lidia, Kour, Smit, King, Hannah M., Sonawane, Yogesh A., Crawford, Ayrianne J., Gautam, Nagsen, Kizhake, Smitha, Bialk, Pawel A., Kmiec, Eric, Mallareddy, Jayapal Reddy, Patil, Prathamesh P., Rana, Sandeep, Singh, Sarbjit, Prahlad, Janani, Grandgenett, Paul M., Borgstahl, Gloria E. O., Ghosal, Gargi, Alnouti, Yazen, Hollingsworth, Michael A., Radhakrishnan, Prakash, Natarajan, Amarnath
Publicado 2022