Toxoplasma gondii Extends the Life Span of Infected Human Neutrophils by Inducing Cytosolic PCNA and Blocking Activation of Apoptotic Caspases

por Lima, Tatiane S., Mallya, Sharmila, Jankeel, Allen, Messaoudi, Ilhem, Lodoen, Melissa B.
Publicado 2021

Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes

por Pandori, William J., Lima, Tatiane S., Mallya, Sharmila, Kao, Tiffany H., Gov, Lanny, Lodoen, Melissa B.
Publicado 2019

Toxoplasma gondii Dysregulates Barrier Function and Mechanotransduction Signaling in Human Endothelial Cells

por Franklin-Murray, Armond L., Mallya, Sharmila, Jankeel, Allen, Sureshchandra, Suhas, Messaoudi, Ilhem, Lodoen, Melissa B.
Publicado 2020

Resistance to mTOR Kinase Inhibitors in Lymphoma Cells Lacking 4EBP1

por Mallya, Sharmila, Fitch, Briana A., Lee, J. Scott, So, Lomon, Janes, Matthew R., Fruman, David A.
Publicado 2014

Effects of Novel Isoform-Selective Phosphoinositide 3-Kinase Inhibitors on Natural Killer Cell Function

por Yea, Sung Su, So, Lomon, Mallya, Sharmila, Lee, Jongdae, Rajasekaran, Kamalakannan, Malarkannan, Subramaniam, Fruman, David A.
Publicado 2014

Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function

por Chiu, Honyin, Buono, Roberta, Jackson, Leandra V., Herzog, Lee-or, Mallya, Sharmila, Conn, Crystal S., Ruggero, Davide, Fruman, David A.
Publicado 2021

mTOR inhibition enhances efficacy of dasatinib in ABL-rearranged Ph-like B-ALL

por Gotesman, Moran, Vo, Thanh-Trang T., Herzog, Lee-Or, Tea, Tiffeny, Mallya, Sharmila, Tasian, Sarah K., Konopleva, Marina, Fruman, David A.
Publicado 2018

mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells

por Beagle, Brandon R., Nguyen, Duc M., Mallya, Sharmila, Tang, Sarah S., Lu, Mengrou, Zeng, Zhihong, Konopleva, Marina, Vo, Thanh-Trang, Fruman, David A.
Publicado 2014

Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition

por Vo, Thanh-Trang, Herzog, Lee-or, Buono, Roberta, Lee, Jong-Hoon Scott, Mallya, Sharmila, Duong, Madeleine R., Thao, Joshua, Gotesman, Moran, Fruman, David A.
Publicado 2021

Efficacy of a Novel Bi-Steric mTORC1 Inhibitor in Models of B-Cell Acute Lymphoblastic Leukemia

por Lee, Bianca J., Mallya, Sharmila, Dinglasan, Nuntana, Fung, Amos, Nguyen, Tram, Herzog, Lee-or, Thao, Joshua, Lorenzana, Edward G., Wildes, David, Singh, Mallika, Smith, Jacqueline A. M., Fruman, David A.
Publicado 2021

The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation

por Chiu, Honyin, Mallya, Sharmila, Nguyen, Phuongthao, Mai, Annie, Jackson, Leandra V., Winkler, David G., DiNitto, Jonathan P., Brophy, Erin E., McGovern, Karen, Kutok, Jeffery L., Fruman, David A.
Publicado 2017

Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax

por Herzog, Lee-or, Walters, Beth, Buono, Roberta, Lee, J. Scott, Mallya, Sharmila, Fung, Amos, Chiu, Honyin, Nguyen, Nancy, Li, Boyang, Pinkerton, Anthony B., Jackson, Michael R., Schneider, Robert J., Ronai, Ze’ev A., Fruman, David A.
Publicado 2020