Room-Temperature, Copper-Free Sonogashira Reactions Facilitated by Air-Stable, Monoligated Precatalyst [DTBNpP] Pd(crotyl)Cl

por Pohida, Katherine, Maloney, David J., Mott, Bryan T., Rai, Ganesha
Publicado 2018

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity

por Dorjsuren, Dorjbal, Kim, Daemyung, Maloney, David J., Wilson, David M., Simeonov, Anton
Publicado 2011

High-Throughput 1,536-Well Fluorescence Polarization Assays for α(1)-Acid Glycoprotein and Human Serum Albumin Binding

por Yasgar, Adam, Furdas, Silviya D., Maloney, David J., Jadhav, Ajit, Jung, Manfred, Simeonov, Anton
Publicado 2012

Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection

por Dorjsuren, Dorjbal, Kim, Daemyung, Vyjayanti, Vaddadi N., Maloney, David J., Jadhav, Ajit, Wilson, David M., Simeonov, Anton
Publicado 2012

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

por Yamanaka, Kinrin, Dorjsuren, Dorjbal, Eoff, Robert L., Egli, Martin, Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Lloyd, R. Stephen
Publicado 2012

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

por Clarke, Jonathan H., Giudici, Maria-Luisa, Burke, John E., Williams, Roger L., Maloney, David J., Marugan, Juan, Irvine, Robin F.
Publicado 2015

A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2

por Jameson, J. Brian, Kantz, Auric, Schultz, Lena, Kalyanaraman, Chakrapani, Jacobson, Matthew P., Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Holman, Theodore R.
Publicado 2014

Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants

por Smith, Steven J., Pauly, Gary T., Akram, Aamir, Melody, Kevin, Rai, Ganesha, Maloney, David J., Ambrose, Zandrea, Thomas, Craig J., Schneider, Joel T., Hughes, Stephen H.
Publicado 2016

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

por Yasgar, Adam, Titus, Steven A., Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Martinez, Natalia J.
Publicado 2017

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

por Yasgar, Adam, Titus, Steven A., Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Martinez, Natalia J.
Publicado 2018

High-Affinity Inhibitors of Human NAD(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships

por Niesen, Frank H., Schultz, Lena, Jadhav, Ajit, Bhatia, Chitra, Guo, Kunde, Maloney, David J., Pilka, Ewa S., Wang, Minghua, Oppermann, Udo, Heightman, Tom D., Simeonov, Anton
Publicado 2010

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

por Sommers, Joshua A., Kulikowicz, Tomasz, Croteau, Deborah L., Dexheimer, Thomas, Dorjsuren, Dorjbal, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Bohr, Vilhelm A., Brosh, Robert M.
Publicado 2019

Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain Inhibitors

por Ferreira, Rafaela S., Simeonov, Anton, Jadhav, Ajit, Eidam, Oliv, Mott, Bryan T., Keiser, Michael J., McKerrow, James H., Maloney, David J., Irwin, John J., Shoichet, Brian K.
Publicado 2010

Synthesis and Structure–Activity Relationship Studies of N-Benzyl-2-phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity again...

por Dexheimer, Thomas S., Rosenthal, Andrew S., Luci, Diane K., Liang, Qin, Villamil, Mark A., Chen, Junjun, Sun, Hongmao, Kerns, Edward H., Simeonov, Anton, Jadhav, Ajit, Zhuang, Zhihao, Maloney, David J.
Publicado 2014

Suppression of the FOXM1 transcriptional program via novel small molecule inhibition

por Gormally, Michael V., Dexheimer, Thomas S., Marsico, Giovanni, Sanders, Deborah A., Lowe, Christopher, Matak-Vinkovi, Dijana, Michael, Sam, Jadhav, Ajit, Rai, Ganesha, Maloney, David J., Simeonov, Anton, Balasubramanian, Shankar
Publicado 2014

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

por Manthei, Kelly A, Yang, Shyh-Ming, Baljinnyam, Bolormaa, Chang, Louise, Glukhova, Alisa, Yuan, Wenmin, Freeman, Lita A, Maloney, David J, Schwendeman, Anna, Remaley, Alan T, Jadhav, Ajit, Tesmer, John JG
Publicado 2018

4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a Potent Inhibitor of Bacterial Phosphopantetheinyl Transferase That Atte...

por Foley, Timothy L., Rai, Ganesha, Yasgar, Adam, Daniel, Thomas, Baker, Heather L., Attene-Ramos, Matias, Kosa, Nicolas M., Leister, William, Burkart, Michael D., Jadhav, Ajit, Simeonov, Anton, Maloney, David J.
Publicado 2014

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants

por Johnson, Barry C, Pauly, Gary T, Rai, Ganesha, Patel, Disha, Bauman, Joseph D, Baker, Heather L, Das, Kalyan, Schneider, Joel P, Maloney, David J, Arnold, Eddy, Thomas, Craig J, Hughes, Stephen H
Publicado 2012

Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

por Hoobler, Eric K., Rai, Ganesha, Warrilow, Andrew G. S., Perry, Steven C., Smyrniotis, Christopher J., Jadhav, Ajit, Simeonov, Anton, Parker, Josie E., Kelly, Diane E., Maloney, David J., Kelly, S. L., Holman, Theodore R.
Publicado 2013

Covalent Small Molecule Inhibitors of Ca(2+)-Bound S100B

por Cavalier, Michael C., Pierce, Adam D., Wilder, Paul T., Alasady, Milad J., Hartman, Kira G., Neau, David B., Foley, Timothy L., Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Toth, Eric A., Weber, David J.
Publicado 2014