Structural and biochemical analysis of the metallo‐β‐lactamase L1 from emerging pathogen Stenotrophomonas maltophilia revealed the subtle but distinct di‐metal scaffold for catalyt...

por Kim, Youngchang, Maltseva, Natalia, Wilamowski, Mateusz, Tesar, Christine, Endres, Michael, Joachimiak, Andrzej
Publicado 2019

Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens

por Mullowney, Michael W., Maltseva, Natalia I., Endres, Michael, Kim, Youngchang, Joachimiak, Andrzej, Crofts, Terence S.
Publicado 2022

Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes

por Michalska, Karolina, Kim, Youngchang, Jedrzejczak, Robert, Maltseva, Natalia I., Stols, Lucy, Endres, Michael, Joachimiak, Andrzej
Publicado 2020

Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2

por Kim, Youngchang, Jedrzejczak, Robert, Maltseva, Natalia I., Wilamowski, Mateusz, Endres, Michael, Godzik, Adam, Michalska, Karolina, Joachimiak, Andrzej
Publicado 2020

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

por Kim, Youngchang, Wower, Jacek, Maltseva, Natalia, Chang, Changsoo, Jedrzejczak, Robert, Wilamowski, Mateusz, Kang, Soowon, Nicolaescu, Vlad, Randall, Glenn, Michalska, Karolina, Joachimiak, Andrzej
Publicado 2021

Catalytically impaired TrpA subunit of tryptophan synthase from Chlamydia trachomatis is an allosteric regulator of TrpB

por Michalska, Karolina, Wellington, Samantha, Maltseva, Natalia, Jedrzejczak, Robert, Selem‐Mojica, Nelly, Rosas‐Becerra, L. Rodrigo, Barona‐Gómez, Francisco, Hung, Deborah T., Joachimiak, Andrzej
Publicado 2021

A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity

por Makowska-Grzyska, Magdalena, Kim, Youngchang, Maltseva, Natalia, Osipiuk, Jerzy, Gu, Minyi, Zhang, Minjia, Mandapati, Kavitha, Gollapalli, Deviprasad R., Gorla, Suresh Kumar, Hedstrom, Lizbeth, Joachimiak, Andrzej
Publicado 2015

Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds

por Makowska-Grzyska, Magdalena, Kim, Youngchang, Gorla, Suresh Kumar, Wei, Yang, Mandapati, Kavitha, Zhang, Minjia, Maltseva, Natalia, Modi, Gyan, Boshoff, Helena I., Gu, Minyi, Aldrich, Courtney, Cuny, Gregory D., Hedstrom, Lizbeth, Joachimiak, Andrzej
Publicado 2015

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine

por Rosas-Lemus, Monica, Minasov, George, Shuvalova, Ludmilla, Inniss, Nicole L., Kiryukhina, Olga, Wiersum, Grant, Kim, Youngchang, Jedrzejczak, Robert, Maltseva, Natalia I., Endres, Michael, Jaroszewski, Lukasz, Godzik, Adam, Joachimiak, Andrzej, Satchell, Karla J. F.
Publicado 2020

2′-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography

por Wilamowski, Mateusz, Sherrell, Darren A., Minasov, George, Kim, Youngchang, Shuvalova, Ludmilla, Lavens, Alex, Chard, Ryan, Maltseva, Natalia, Jedrzejczak, Robert, Rosas-Lemus, Monica, Saint, Nickolaus, Foster, Ian T., Michalska, Karolina, Satchell, Karla J. F., Joachimiak, Andrzej
Publicado 2021

A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile

por Rosas-Lemus, Monica, Dey, Supratim, Minasov, George, Tan, Kemin, Anderson, Spencer M., Brunzelle, Joseph, Nocadello, Salvatore, Shabalin, Ivan, Filippova, Ekaterina, Halavaty, Andrei, Kim, Youngchang, Maltseva, Natalia, Osipiuk, Jerzy, Minor, Wladek, Joachimiak, Andrzej, Savchenko, Alexei, Anderson, Wayne F., Satchell, Karla J. F.
Publicado 2023

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

por Drayman, Nir, DeMarco, Jennifer K., Jones, Krysten A., Azizi, Saara-Anne, Froggatt, Heather M., Tan, Kemin, Maltseva, Natalia Ivanovna, Chen, Siquan, Nicolaescu, Vlad, Dvorkin, Steve, Furlong, Kevin, Kathayat, Rahul S., Firpo, Mason R., Mastrodomenico, Vincent, Bruce, Emily A., Schmidt, Madaline M., Jedrzejczak, Robert, Muñoz-Alía, Miguel Á., Schuster, Brooke, Nair, Vishnu, Han, Kyu-yeon, O’Brien, Amornrat, Tomatsidou, Anastasia, Meyer, Bjoern, Vignuzzi, Marco, Missiakas, Dominique, Botten, Jason W., Brooke, Christopher B., Lee, Hyun, Baker, Susan C., Mounce, Bryan C., Heaton, Nicholas S., Severson, William E., Palmer, Kenneth E., Dickinson, Bryan C., Joachimiak, Andrzej, Randall, Glenn, Tay, Savaş
Publicado 2021