SH2-Catalytic Domain Linker Heterogeneity Influences Allosteric Coupling across the SFK Family

por Register, A. C., Leonard, Stephen E., Maly, Dustin J.
Publicado 2014

Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance

por Zhang, Jason Z., Ong, Shao-En, Baker, David, Maly, Dustin J.
Publicado 2023

Divergent Modulation of Src-Family Kinase Regulatory Interactions with ATP-Competitive Inhibitors

por Leonard, Stephen E., Register, A. C., Krishnamurty, Ratika, Brighty, Gabriel J., Maly, Dustin J.
Publicado 2014

Rheostatic Control of Cas9-Mediated DNA Double Strand Break (DSB) Generation and Genome Editing

por Rose, John C., Stephany, Jason J., Wei, Cindy T., Fowler, Douglas M., Maly, Dustin J.
Publicado 2017

Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G

por Bansal, Abhisheka, Ojo, Kayode K., Mu, Jianbing, Maly, Dustin J., Van Voorhis, Wesley C., Miller, Louis H.
Publicado 2016

Active site profiling reveals coupling between domains in SRC-family kinases

por Krishnamurty, Ratika, Brigham, Jennifer L., Leonard, Stephen E., Ranjitkar, Pratistha, Larson, Eric T., Dale, Edward J., Merritt, Ethan A., Maly, Dustin J.
Publicado 2012

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics

por Rose, John C., Stephany, Jason J., Valente, William J., Trevillian, Bridget M., Dang, Ha V., Bielas, Jason H., Maly, Dustin J., Fowler, Douglas M.
Publicado 2017

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

por Thamsen, Maike, Ghosh, Rajarshi, Auyeung, Vincent C., Brumwell, Alexis, Chapman, Harold A., Backes, Bradley J., Perara, Gayani, Maly, Dustin J., Sheppard, Dean, Papa, Feroz R.
Publicado 2019

Subcellular drug targeting illuminates local kinase action

por Bucko, Paula J, Lombard, Chloe K, Rathbun, Lindsay, Garcia, Irvin, Bhat, Akansha, Wordeman, Linda, Smith, F Donelson, Maly, Dustin J, Hehnly, Heidi, Scott, John D
Publicado 2019

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs

por Rose, John C., Popp, Nicholas A., Richardson, Christopher D., Stephany, Jason J., Mathieu, Julie, Wei, Cindy T., Corn, Jacob E., Maly, Dustin J., Fowler, Douglas M.
Publicado 2020

Multi-input chemical control of protein dimerization for programming graded cellular responses

por Foight, Glenna Wink, Wang, Zhizhi, Wei, Cindy T., Greisen, Per, Warner, Katrina M., Cunningham-Bryant, Daniel, Park, Keunwan, Brunette, T. J., Sheffler, William, Baker, David, Maly, Dustin J.
Publicado 2019

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

por Wang, Likun, Perera, B. Gayani K., Hari, Sanjay B., Bhhatarai, Barun, Backes, Bradley J., Seeliger, Markus A., Schürer, Stephan C., Oakes, Scott A., Papa, Feroz R., Maly, Dustin J.
Publicado 2012

A computationally engineered RAS rheostat reveals RAS/ERK signaling dynamics

por Rose, John C., Huang, Po-Ssu, Camp, Nathan D., Ye, Jordan, Leidal, Andrew M., Goreshnik, Inna, Trevillian, Bridget M., Dickinson, Miles S., Cunningham-Bryant, Daniel, Debnath, Jayanta, Baker, David, Wolf-Yadlin, Alejandro, Maly, Dustin J.
Publicado 2016

P-Glycoprotein–Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium

por Arnold, Samuel L M, Choi, Ryan, Hulverson, Matthew A, Whitman, Grant R, Mccloskey, Molly C, Dorr, Carlie S, Vidadala, Rama S R, Khatod, Mansi, Morada, Mary, Barrett, Lynn K, Maly, Dustin J, Yarlett, Nigel, Van Voorhis, Wesley C
Publicado 2019

ATP-Competitive Partial Antagonists of IRE1α’s RNase Segregate Outputs of the UPR

por Feldman, Hannah C., Ghosh, Rajarshi, Auyeung, Vincent C., Mueller, James L., Kim, Jae-Hong, Potter, Zachary E., Vidadala, Venkata N., Perera, B. Gayani K., Olivier, Alina, Backes, Bradley J., Zikherman, Julie, Papa, Feroz R., Maly, Dustin J.
Publicado 2021

Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy

por Ojo, Kayode K., Reid, Molly C., Kallur Siddaramaiah, Latha, Müller, Joachim, Winzer, Pablo, Zhang, Zhongsheng, Keyloun, Katelyn R., Vidadala, Rama Subba Rao, Merritt, Ethan A., Hol, Wim G. J., Maly, Dustin J., Fan, Erkang, Van Voorhis, Wesley C., Hemphill, Andrew
Publicado 2014

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

por Arnold, Samuel L. M., Choi, Ryan, Hulverson, Matthew A., Schaefer, Deborah A., Vinayak, Sumiti, Vidadala, Rama S. R., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Barrett, Lynn K., Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C.
Publicado 2017

Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro

por Shrestha, Aruna, Ojo, Kayode K., Koston, Florian, Ruttkowski, Bärbel, Vidadala, Rama S.R., Dorr, Carlie S., Navaluna, Edelmar D., Whitman, Grant R., Barrett, Kayleigh F., Barrett, Lynn K., Hulverson, Matthew A., Choi, Ryan, Michaels, Samantha A., Maly, Dustin J., Hemphill, Andrew, Van Voorhis, Wesley C., Joachim, Anja
Publicado 2019

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

por Crowther, Gregory J., Hillesland, Heidi K., Keyloun, Katelyn R., Reid, Molly C., Lafuente-Monasterio, Maria Jose, Ghidelli-Disse, Sonja, Leonard, Stephen E., He, Panqing, Jones, Jackson C., Krahn, Mallory M., Mo, Jack S., Dasari, Kartheek S., Fox, Anna M. W., Boesche, Markus, El Bakkouri, Majida, Rivas, Kasey L., Leroy, Didier, Hui, Raymond, Drewes, Gerard, Maly, Dustin J., Van Voorhis, Wesley C., Ojo, Kayode K.
Publicado 2016

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

por Huang, Wenlin, Ojo, Kayode K., Zhang, Zhongsheng, Rivas, Kasey, Vidadala, Rama Subba Rao, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Hulverson, Matthew A., Barrett, Lynn K., Bruzual, Igor, Siddaramaiah, Latha Kallur, Kerchner, Keshia M., Kurnick, Matthew D., Freiberg, Gail M., Kempf, Dale, Hol, Wim G. J., Merritt, Ethan A., Neckermann, Georg, de Hostos, Eugenio L., Isoherranen, Nina, Maly, Dustin J., Parsons, Marilyn, Doggett, J. Stone, Van Voorhis, Wesley C., Fan, Erkang
Publicado 2015