HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function

por Richardson, Simone I., Ayres, Frances, Manamela, Nelia P., Oosthuysen, Brent, Makhado, Zanele, Lambson, Bronwen E., Morris, Lynn, Moore, Penny L.
Publicado 2021

Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

por Moyo-Gwete, Thandeka, Scheepers, Cathrine, Makhado, Zanele, Kgagudi, Prudence, Mzindle, Nonkululeko B., Ziki, Rutendo, Madzorera, Sharon, Manamela, Nelia P., Ayres, Frances, Lambson, Bronwen E., Richardson, Simone I., Morris, Lynn, Moore, Penny L.
Publicado 2022

Despite delayed kinetics, people living with HIV achieve equivalent antibody function after SARS-CoV-2 infection or vaccination

por Motsoeneng, Boitumelo M., Manamela, Nelia P., Kaldine, Haajira, Kgagudi, Prudence, Hermanus, Tandile, Ayres, Frances, Makhado, Zanele, Moyo-Gwete, Thandeka, van der Mescht, Mieke A., Abdullah, Fareed, Boswell, Michael T., Ueckermann, Veronica, Rossouw, Theresa M., Madhi, Shabir A., Moore, Penny L., Richardson, Simone I.
Publicado 2023

SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity

por Richardson, Simone I., Manamela, Nelia P., Motsoeneng, Boitumelo M., Kaldine, Haajira, Ayres, Frances, Makhado, Zanele, Mennen, Mathilda, Skelem, Sango, Williams, Noleen, Sullivan, Nancy J., Misasi, John, Gray, Glenda G., Bekker, Linda-Gail, Ueckermann, Veronica, Rossouw, Theresa M., Boswell, Michael T., Ntusi, Ntobeko A.B., Burgers, Wendy A., Moore, Penny L.
Publicado 2022

Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants

por Moyo-Gwete, Thandeka, Madzivhandila, Mashudu, Mkhize, Nonhlanhla N., Kgagudi, Prudence, Ayres, Frances, Lambson, Bronwen E., Manamela, Nelia P., Richardson, Simone I., Makhado, Zanele, van der Mescht, Mieke A., de Beer, Zelda, de Villiers, Talita Roma, Burgers, Wendy A., Ntusi, Ntobeko A. B., Rossouw, Theresa, Ueckermann, Veronica, Boswell, Michael T., Moore, Penny L.
Publicado 2022

Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection

por Moyo-Gwete, Thandeka, Richardson, Simone I., Keeton, Roanne, Hermanus, Tandile, Spencer, Holly, Manamela, Nelia P., Ayres, Frances, Makhado, Zanele, Motlou, Thopisang, Tincho, Marius B., Benede, Ntombi, Ngomti, Amkele, Baguma, Richard, Chauke, Masego V., Mennen, Mathilda, Adriaanse, Marguerite, Skelem, Sango, Goga, Ameena, Garrett, Nigel, Bekker, Linda-Gail, Gray, Glenda, Ntusi, Ntobeko A.B., Riou, Catherine, Burgers, Wendy A., Moore, Penny L.
Publicado 2023

Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells

por Krause, Robert G. E., Moyo-Gwete, Thandeka, Richardson, Simone I., Makhado, Zanele, Manamela, Nelia P., Hermanus, Tandile, Mkhize, Nonhlanhla N., Keeton, Roanne, Benede, Ntombi, Mennen, Mathilda, Skelem, Sango, Karim, Farina, Khan, Khadija, Riou, Catherine, Ntusi, Ntobeko A. B., Goga, Ameena, Gray, Glenda, Hanekom, Willem, Garrett, Nigel, Bekker, Linda-Gail, Groll, Andreas, Sigal, Alex, Moore, Penny L., Burgers, Wendy A., Leslie, Alasdair
Publicado 2023

Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection

por Moyo-Gwete, Thandeka, Richardson, Simone I., Keeton, Roanne, Hermanus, Tandile, Spencer, Holly, Manamela, Nelia P., Ayres, Frances, Makhado, Zanele, Motlou, Thopisang, Tincho, Marius B., Benede, Ntombi, Ngomti, Amkele, Baguma, Richard, Chauke, Masego V., Mennen, Mathilda, Adriaanse, Marguerite, Skelem, Sango, Goga, Ameena, Garrett, Nigel, Bekker, Linda-Gail, Gray, Glenda, Ntusi, Ntobeko A. B., Riou, Catherine, Burgers, Wendy A., Moore, Penny L.
Publicado 2023

Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant

por Richardson, Simone I., Kgagudi, Prudence, Manamela, Nelia P., Kaldine, Haajira, Venter, Elizabeth M., Pillay, Thanusha, Lambson, Bronwen E., van der Mescht, Mieke A., Hermanus, Tandile, Balla, Sashkia R., de Beer, Zelda, de Villiers, Talita R., Bodenstein, Annie, van den Berg, Gretha, du Pisanie, Marizane, Burgers, Wendy A., Ntusi, Ntobeko A.B., Abdullah, Fareed, Ueckermann, Veronica, Rossouw, Theresa M., Boswell, Michael T., Moore, Penny L.
Publicado 2022

Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern

por Kitchin, Dale, Richardson, Simone I., van der Mescht, Mieke A., Motlou, Thopisang, Mzindle, Nonkululeko, Moyo-Gwete, Thandeka, Makhado, Zanele, Ayres, Frances, Manamela, Nelia P., Spencer, Holly, Lambson, Bronwen, Oosthuysen, Brent, Kaldine, Haajira, du Pisanie, Marizane, Mennen, Mathilda, Skelem, Sango, Williams, Noleen, Ntusi, Ntobeko A.B., Burgers, Wendy A., Gray, Glenda G., Bekker, Linda-Gail, Boswell, Michael T., Rossouw, Theresa M., Ueckermann, Veronica, Moore, Penny L.
Publicado 2022

SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals

por Richardson, Simone I., Madzorera, Vimbai Sharon, Spencer, Holly, Manamela, Nelia P., van der Mescht, Mieke A., Lambson, Bronwen E., Oosthuysen, Brent, Ayres, Frances, Makhado, Zanele, Moyo-Gwete, Thandeka, Mzindle, Nonkululeko, Motlou, Thopisang, Strydom, Amy, Mendes, Adriano, Tegally, Houriiyah, de Beer, Zelda, Roma de Villiers, Talita, Bodenstein, Annie, van den Berg, Gretha, Venter, Marietjie, de Oliviera, Tulio, Ueckermann, Veronica, Rossouw, Theresa M., Boswell, Michael T., Moore, Penny L.
Publicado 2022

Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions

por Shiakolas, Andrea R., Kramer, Kevin J., Wrapp, Daniel, Richardson, Simone I., Schäfer, Alexandra, Wall, Steven, Wang, Nianshuang, Janowska, Katarzyna, Pilewski, Kelsey A., Venkat, Rohit, Parks, Robert, Manamela, Nelia P., Raju, Nagarajan, Fechter, Emilee Friedman, Holt, Clinton M., Suryadevara, Naveenchandra, Chen, Rita E., Martinez, David R., Nargi, Rachel S., Sutton, Rachel E., Ledgerwood, Julie E., Graham, Barney S., Diamond, Michael S., Haynes, Barton F., Acharya, Priyamvada, Carnahan, Robert H., Crowe, James E., Baric, Ralph S., Morris, Lynn, McLellan, Jason S., Georgiev, Ivelin S.
Publicado 2021

Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner

por Keeton, Roanne, Richardson, Simone I., Moyo-Gwete, Thandeka, Hermanus, Tandile, Tincho, Marius B., Benede, Ntombi, Manamela, Nelia P., Baguma, Richard, Makhado, Zanele, Ngomti, Amkele, Motlou, Thopisang, Mennen, Mathilda, Chinhoyi, Lionel, Skelem, Sango, Maboreke, Hazel, Doolabh, Deelan, Iranzadeh, Arash, Otter, Ashley D., Brooks, Tim, Noursadeghi, Mahdad, Moon, James C., Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Blackburn, Jonathan, Hsiao, Nei-Yuan, Williamson, Carolyn, Riou, Catherine, Goga, Ameena, Garrett, Nigel, Bekker, Linda-Gail, Gray, Glenda, Ntusi, Ntobeko A.B., Moore, Penny L., Burgers, Wendy A.
Publicado 2021

Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005): a post-hoc analysi...

por Madhi, Shabir A, Kwatra, Gaurav, Richardson, Simone I, Koen, Anthonet L, Baillie, Vicky, Cutland, Clare L, Fairlie, Lee, Padayachee, Sherman D, Dheda, Keertan, Barnabas, Shaun L, Bhorat, Qasim Ebrahim, Briner, Carmen, Ahmed, Khatija, Aley, Parvinder K, Bhikha, Sutika, Bhorat, A E, Esmail, Aliasgar, Horne, Elizea, Kaldine, Haajira, Mukendi, Christian K, Madzorera, Vimbai Sharon, Manamela, Nelia P, Masilela, Mduduzi, Hermanus, S Tandile, Motlou, Thopisang, Mzindle, Nonkululeko, Oelofse, Suzette, Patel, Faeezah, Rhead, Sarah, Rossouw, Lindie, Taoushanis, Carol, van Eck, Samuel, Lambe, Teresa, Gilbert, Sarah C, Pollard, Andrew J, Moore, Penny L, Izu, Alane
Publicado 2023

Functional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor

por Pilewski, Kelsey A., Wall, Steven, Richardson, Simone I., Manamela, Nelia P., Clark, Kaitlyn, Hermanus, Tandile, Binshtein, Elad, Venkat, Rohit, Sautto, Giuseppe A., Kramer, Kevin J., Shiakolas, Andrea R., Setliff, Ian, Salas, Jordan, Mapengo, Rutendo E., Suryadevara, Naveen, Brannon, John R., Beebout, Connor J., Parks, Rob, Raju, Nagarajan, Frumento, Nicole, Walker, Lauren M., Fechter, Emilee Friedman, Qin, Juliana S., Murji, Amyn A., Janowska, Katarzyna, Thakur, Bhishem, Lindenberger, Jared, May, Aaron J., Huang, Xiao, Sammour, Salam, Acharya, Priyamvada, Carnahan, Robert H., Ross, Ted M., Haynes, Barton F., Hadjifrangiskou, Maria, Crowe, James E., Bailey, Justin R., Kalams, Spyros, Morris, Lynn, Georgiev, Ivelin S.
Publicado 2023