A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase

por Strembitska, Anastasiya, Mancini, Sarah J., Gamwell, Jonathan M., Palmer, Timothy M., Baillie, George S., Salt, Ian P.
Publicado 2018

Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanism...

por Mancini, Sarah J., Boyd, Daria, Katwan, Omar J., Strembitska, Anastasiya, Almabrouk, Tarek A., Kennedy, Simon, Palmer, Timothy M., Salt, Ian P.
Publicado 2018

AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis

por Katwan, Omar J., Alghamdi, Fatmah, Almabrouk, Tarek A., Mancini, Sarah J., Kennedy, Simon, Oakhill, Jonathan S., Scott, John W., Salt, Ian P.
Publicado 2019

Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487

por Heathcote, Helen R., Mancini, Sarah J., Strembitska, Anastasiya, Jamal, Kunzah, Reihill, James A., Palmer, Timothy M., Gould, Gwyn W., Salt, Ian P.
Publicado 2016

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation

por Mancini, Sarah J., White, Anna D., Bijland, Silvia, Rutherford, Claire, Graham, Delyth, Richter, Erik A., Viollet, Benoit, Touyz, Rhian M., Palmer, Timothy M., Salt, Ian P.
Publicado 2017

On-target and off-target effects of novel orthosteric and allosteric activators of GPR84

por Mancini, Sarah J., Mahmud, Zobaer Al, Jenkins, Laura, Bolognini, Daniele, Newman, Robert, Barnes, Matt, Edye, Michelle E., McMahon, Stephen B., Tobin, Andrew B., Milligan, Graeme
Publicado 2019

Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84

por Jenkins, Laura, Marsango, Sara, Mancini, Sarah, Mahmud, Zobaer Al, Morrison, Angus, McElroy, Stuart P., Bennett, Kirstie A., Barnes, Matt, Tobin, Andrew B., Tikhonova, Irina G., Milligan, Graeme
Publicado 2021