Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration

por Mander, Palwinder, Brown, Guy C
Publicado 2005

Fibrillar beta-amyloid peptide Aβ(1–40 )activates microglial proliferation via stimulating TNF-α release and H(2)O(2 )derived from NADPH oxidase: a cell culture study

por Jekabsone, Aiste, Mander, Palwinder K, Tickler, Anna, Sharpe, Martyn, Brown, Guy C
Publicado 2006

Classic and new mediators for in vitro modelling of human macrophages

por Luque‐Martin, Rosario, Mander, Palwinder K., Leenen, Pieter J. M., Winther, Menno P. J.
Publicado 2020

BET Inhibition Improves NASH and Liver Fibrosis

por Middleton, Sarah A., Rajpal, Neetu, Cutler, Leanne, Mander, Palwinder, Rioja, Inmaculada, Prinjha, Rab K., Rajpal, Deepak, Agarwal, Pankaj, Kumar, Vinod
Publicado 2018

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

por Fu, Wenxian, Farache, Julia, Clardy, Susan M, Hattori, Kimie, Mander, Palwinder, Lee, Kevin, Rioja, Inmaculada, Weissleder, Ralph, Prinjha, Rab K, Benoist, Christophe, Mathis, Diane
Publicado 2014

Pharmacological validation of targets regulating CD14 during macrophage differentiation

por Jimenez-Duran, Gisela, Luque-Martin, Rosario, Patel, Meghana, Koppe, Emma, Bernard, Sharon, Sharp, Catriona, Buchan, Natalie, Rea, Ceara, de Winther, Menno P.J., Turan, Nil, Angell, Davina, Wells, Christine A., Cousins, Rick, Mander, Palwinder K., Masters, Seth L.
Publicado 2020

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

por Cribbs, Adam P., Terlecki-Zaniewicz, Stefan, Philpott, Martin, Baardman, Jeroen, Ahern, David, Lindow, Morten, Obad, Susanna, Oerum, Henrik, Sampey, Brante, Mander, Palwinder K., Penn, Henry, Wordsworth, Paul, Bowness, Paul, de Winther, Menno, Prinjha, Rab K., Feldmann, Marc, Oppermann, Udo
Publicado 2020

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

por Luque-Martin, Rosario, Van den Bossche, Jan, Furze, Rebecca C., Neele, Annette E., van der Velden, Saskia, Gijbels, Marion J.J., van Roomen, Cindy P.P.A., Bernard, Sharon G., de Jonge, Wouter J., Rioja, Inmaculada, Prinjha, Rab K., Lewis, Huw D., Mander, Palwinder K., de Winther, Menno P.J.
Publicado 2019

A randomized study of the safety and pharmacokinetics of GSK3358699, a mononuclear myeloid‐targeted bromodomain and extra‐terminal domain inhibitor

por Brown, Jack A., Bal, Joanne, Simeoni, Monica, Williams, Peter, Mander, Palwinder K., Soden, Peter E., Daga, Shruti, Fahy, William A., Wong, Gabriel K., Bloomer, Jackie C., Erwig, Lars, Cui, Yi, Fernando, Disala, Carnaghan, Helen, Banham‐Hall, Edward J., Hopkins, Sarah, Davis, Bill G., Oliveira, Joao J. D., Prinjha, Rabinder K.
Publicado 2021

A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn’s Disease

por Elfiky, Ahmed M. I., Hageman, Ishtu L., Becker, Marte A. J., Verhoeff, Jan, Li Yim, Andrew Y. F., Joustra, Vincent W., Mulders, Lieven, Fung, Ivan, Rioja, Inmaculada, Prinjha, Rab K., Smithers, Nicholas N., Furze, Rebecca C., Mander, Palwinder K., Bell, Matthew J., Buskens, Christianne J., D’Haens, Geert R., Wildenberg, Manon E., de Jonge, Wouter J.
Publicado 2022

Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease

por Elfiky, Ahmed M I, Ghiboub, Mohammed, Li Yim, Andrew Y F, Hageman, Ishtu L, Verhoeff, Jan, de Krijger, Manon, van Hamersveld, Patricia H P, Welting, Olaf, Admiraal, Iris, Rahman, Shafaque, Garcia-Vallejo, Juan J, Wildenberg, Manon E, Tomlinson, Laura, Gregory, Richard, Rioja, Inmaculada, Prinjha, Rab K, Furze, Rebecca C, Lewis, Huw D, Mander, Palwinder K, Heinsbroek, Sigrid E M, Bell, Matthew J, de Jonge, Wouter J
Publicado 2021

Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility

por Douthwaite, Julie A., Brown, Christopher A., Ferdinand, John R., Sharma, Rahul, Elliott, Jane, Taylor, Molly A., Malintan, Nancy T., Duvoisin, Hannah, Hill, Thomas, Delpuech, Oona, Orton, Alexandra L., Pitt, Haidee, Kuenzi, Fred, Fish, Simon, Nicholls, David J., Cuthbert, Anna, Richards, Ian, Ratcliffe, Giles, Upadhyay, Abhishek, Marklew, Abigail, Hewitt, Craig, Ross-Thriepland, Douglas, Brankin, Christopher, Chodorge, Matthieu, Browne, Gareth, Mander, Palwinder K., DeWildt, Ruud M., Weaver, Shane, Smee, Penny A., van Kempen, Joost, Bartlett, Jon G., Allen, Paula M., Koppe, Emma L., Ashby, Charlotte A., Phipps, Julian D., Mehta, Nalini, Brierley, David J., Tew, David G., Leveridge, Melanie V., Baddeley, Stuart M., Goodfellow, Ian G., Green, Clive, Abell, Chris, Neely, Andy, Waddell, Ian, Rees, Steve, Maxwell, Patrick H., Pangalos, Menelas N., Howes, Rob, Clark, Roger
Publicado 2022