The Dynamics of Somatic Mutagenesis During Life in Humans

por Manders, Freek, van Boxtel, Ruben, Middelkamp, Sjors
Publicado 2021

Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells

por Manders, Freek, van Dinter, Jip, van Boxtel, Ruben
Publicado 2022

A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs

por Yu, Yun, Manders, Freek, Grinwis, Guy C. M., Groenen, Martien A. M., Crooijmans, Richard P. M. A.
Publicado 2022

Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis

por Hasaart, Karlijn A. L., Manders, Freek, van der Hoorn, Marie-Louise, Verheul, Mark, Poplonski, Tomasz, Kuijk, Ewart, de Sousa Lopes, Susana M. Chuva, van Boxtel, Ruben
Publicado 2020

Mutation Signatures of Pediatric Acute Myeloid Leukemia and Normal Blood Progenitors Associated with Differential Patient Outcomes

por Brandsma, Arianne M., Bertrums, Eline J.M., van Roosmalen, Markus J., Hofman, Damon A., Oka, Rurika, Verheul, Mark, Manders, Freek, Ubels, Joske, Belderbos, Mirjam E., van Boxtel, Ruben
Publicado 2021

MutationalPatterns: the one stop shop for the analysis of mutational processes

por Manders, Freek, Brandsma, Arianne M., de Kanter, Jurrian, Verheul, Mark, Oka, Rurika, van Roosmalen, Markus J., van der Roest, Bastiaan, van Hoeck, Arne, Cuppen, Edwin, van Boxtel, Ruben
Publicado 2022

Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells in vivo

por Hasaart, Karlijn A.L., Manders, Freek, Ubels, Joske, Verheul, Mark, van Roosmalen, Markus J., Groenen, Niels M., Oka, Rurika, Kuijk, Ewart, Lopes, Susana M. Chuva de Sousa, Boxtel, Ruben van
Publicado 2022

Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients

por de Kanter, Jurrian K., Peci, Flavia, Bertrums, Eline, Rosendahl Huber, Axel, van Leeuwen, Anaïs, van Roosmalen, Markus J., Manders, Freek, Verheul, Mark, Oka, Rurika, Brandsma, Arianne M., Bierings, Marc, Belderbos, Mirjam, van Boxtel, Ruben
Publicado 2021

Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox

por Middelkamp, Sjors, Manders, Freek, Peci, Flavia, van Roosmalen, Markus J., González, Diego Montiel, Bertrums, Eline J.M., van der Werf, Inge, Derks, Lucca L.M., Groenen, Niels M., Verheul, Mark, Trabut, Laurianne, Pleguezuelos-Manzano, Cayetano, Brandsma, Arianne M., Antoniou, Evangelia, Reinhardt, Dirk, Bierings, Marc, Belderbos, Mirjam E., van Boxtel, Ruben
Publicado 2023

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

por Meister, Michael T, Groot Koerkamp, Marian J A, de Souza, Terezinha, Breunis, Willemijn B, Frazer‐Mendelewska, Ewa, Brok, Mariël, DeMartino, Jeff, Manders, Freek, Calandrini, Camilla, Kerstens, Hinri H D, Janse, Alex, Dolman, M Emmy M, Eising, Selma, Langenberg, Karin P S, van Tuil, Marc, Knops, Rutger R G, van Scheltinga, Sheila Terwisscha, Hiemcke‐Jiwa, Laura S, Flucke, Uta, Merks, Johannes H M, van Noesel, Max M, Tops, Bastiaan B J, Hehir‐Kwa, Jayne Y, Kemmeren, Patrick, Molenaar, Jan J, van de Wetering, Marc, van Boxtel, Ruben, Drost, Jarno, Holstege, Frank C P
Publicado 2022