ENHANZE(®) drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20

por Locke, Kenneth W., Maneval, Daniel C., LaBarre, Michael J.
Publicado 2019

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Hyaluronidase PH20 Administered Intravenously in Healthy Volunteer...

por Printz, Marie A., Dychter, Samuel S., DeNoia, Emanuel P., Harrigan, Rena, Sugarman, Barry J., Zepeda, Monica, Souratha, Jennifer, Kang, David W., Maneval, Daniel C.
Publicado 2020

Safety and pharmacokinetics of docetaxel in combination with pegvorhyaluronidase alfa in patients with non‐small cell lung cancer

por Heineman, Thomas, Baumgart, Megan, Nanavati, Charvi, Gabrail, Nash, Van Wart, Scott A., Mager, Donald E., Maneval, Daniel C., Fathallah, Anas M., Sekulovich, Rose E.
Publicado 2021

JNTX-101, a novel albumin-encapsulated gemcitabine prodrug, is efficacious and operates via caveolin-1-mediated endocytosis

por Cui, Tiantian, Corrales-Guerrero, Sergio, Castro-Aceituno, Veronica, Nair, Sindhu, Maneval, Daniel C., Monnig, Curtis, Kearney, Patrick, Ellis, Sam, Raheja, Nicholas, Raheja, Neil, Williams, Terence M.
Publicado 2023

Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours

por Infante, Jeffrey R, Korn, Ronald L, Rosen, Lee S, LoRusso, Patricia, Dychter, Samuel S, Zhu, Joy, Maneval, Daniel C, Jiang, Ping, Shepard, H Michael, Frost, Gregory, Von Hoff, Daniel D, Borad, Mitesh J, Ramanathan, Ramesh K
Publicado 2018

Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours

por Infante, Jeffrey R, Korn, Ronald L, Rosen, Lee S, LoRusso, Patricia, Dychter, Samuel S, Zhu, Joy, Maneval, Daniel C, Jiang, Ping, Shepard, H Michael, Frost, Gregory, Von Hoff, Daniel D, Borad, Mitesh J, Ramanathan, Ramesh K
Publicado 2018

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44

por Zhao, Chunmei, Thompson, Benjamin J., Chen, Kelly, Gao, Feng, Blouw, Barbara, Marella, Mathieu, Zimmerman, Susan, Kimbler, Trevor, Garrovillo, Sheryl, Bahn, Jesse, Huang, Lei, Huang, Zhongdong, Shepard, H. Michael, Rosengren, Sanna, Thanos, Christopher D., Maneval, Daniel C.
Publicado 2019

PH20 is not expressed in murine CNS and oligodendrocyte precursor cells

por Marella, Mathieu, Ouyang, Joe, Zombeck, Jonathan, Zhao, Chunmei, Huang, Lei, Connor, Robert J., Phan, Kim B., Jorge, Michael C., Printz, Marie A., Paladini, Rudolph D., Gelb, Arnold B., Huang, Zhongdong, Frost, Gregory I., Sugarman, Barry J., Steinman, Lawrence, Wei, Ge, Shepard, H. Michael, Maneval, Daniel C., Lapinskas, Paula J.
Publicado 2017

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

por Jacobetz, Michael A, Chan, Derek S, Neesse, Albrecht, Bapiro, Tashinga E, Cook, Natalie, Frese, Kristopher K, Feig, Christine, Nakagawa, Tomoaki, Caldwell, Meredith E, Zecchini, Heather I, Lolkema, Martijn P, Jiang, Ping, Kultti, Anne, Thompson, Curtis B, Maneval, Daniel C, Jodrell, Duncan I, Frost, Gregory I, Shepard, H M, Skepper, Jeremy N, Tuveson, David A
Publicado 2013