Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer

por Niu, Huifeng, Manfredi, Mark, Ecsedy, Jeffrey A.
Publicado 2015

Growth Rate Analysis and Efficient Experimental Design for Tumor Xenograft Studies

por Hather, Gregory, Liu, Ray, Bandi, Syamala, Mettetal, Jerome, Manfredi, Mark, Shyu, Wen-Chyi, Donelan, Jill, Chakravarty, Arijit
Publicado 2014

Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea

por Bannerman, Bret, Xu, Ling, Jones, Matthew, Tsu, Christopher, Yu, Jie, Hales, Paul, Monbaliu, Johan, Fleming, Paul, Dick, Lawrence, Manfredi, Mark, Claiborne, Christopher, Bolen, Joseph, Kupperman, Erik, Berger, Allison
Publicado 2011

KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism

por Chattopadhyay, Nibedita, Berger, Allison J., Koenig, Erik, Bannerman, Bret, Garnsey, James, Bernard, Hugues, Hales, Paul, Maldonado Lopez, Angel, Yang, Yu, Donelan, Jill, Jordan, Kristen, Tirrell, Stephen, Stringer, Bradley, Xia, Cindy, Hather, Greg, Galvin, Katherine, Manfredi, Mark, Rhodes, Nelson, Amidon, Ben
Publicado 2015

A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo

por Gallery, Melissa, Zhang, Julie, Bradley, Daniel P., Brauer, Pamela, Cvet, Donna, Estevam, Jose, Danaee, Hadi, Greenfield, Edward, Li, Ping, Manfredi, Mark, Loke, Huay-Keng, Rabino, Claudia, Stringer, Brad, Williamson, Mark, Wyant, Tim, Yang, Johnny, Zhu, Qing, Abu-Yousif, Adnan, Veiby, O. Petter
Publicado 2018

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

por Campesato, Luis Felipe, Budhu, Sadna, Tchaicha, Jeremy, Weng, Chien-Huan, Gigoux, Mathieu, Cohen, Ivan Jose, Redmond, David, Mangarin, Levi, Pourpe, Stephane, Liu, Cailian, Zappasodi, Roberta, Zamarin, Dmitriy, Cavanaugh, Jill, Castro, Alfredo C., Manfredi, Mark G., McGovern, Karen, Merghoub, Taha, Wolchok, Jedd D.
Publicado 2020

Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer

por Carol, Hernan, Boehm, Ingrid, Reynolds, C. Patrick, Kang, Min H., Maris, John M., Morton, Christopher L., Gorlick, Richard, Kolb, E. Anders, Keir, Stephen T., Wu, Jianrong, Wozniak, Amy E., Yang, Yu, Manfredi, Mark, Ecsedy, Jeffrey, Wang, Jianmin, Neale, Geoffrey, Houghton, Peter J., Smith, Malcolm A., Lock, Richard B.
Publicado 2011

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

por Sells, Todd B., Chau, Ryan, Ecsedy, Jeffrey A., Gershman, Rachel E., Hoar, Kara, Huck, Jessica, Janowick, David A., Kadambi, Vivek J., LeRoy, Patrick J., Stirling, Matthew, Stroud, Stephen G., Vos, Tricia J., Weatherhead, Gabriel S., Wysong, Deborah R., Zhang, Mengkun, Balani, Suresh K., Bolen, Joseph B., Manfredi, Mark G., Claiborne, Christopher F.
Publicado 2015

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

por Tajan, Mylène, Hennequart, Marc, Cheung, Eric C., Zani, Fabio, Hock, Andreas K., Legrave, Nathalie, Maddocks, Oliver D. K., Ridgway, Rachel A., Athineos, Dimitris, Suárez-Bonnet, Alejandro, Ludwig, Robert L., Novellasdemunt, Laura, Angelis, Nikolaos, Li, Vivian S. W., Vlachogiannis, Georgios, Valeri, Nicola, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.
Publicado 2021

Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme

por Triplett, Todd A., Garrison, Kendra C., Marshall, Nicholas, Donkor, Moses, Blazeck, John, Lamb, Candice, Qerqez, Ahlam, Dekker, Joseph D., Tano, Yuri, Wei-Cheng-Lu, Karamitros, Christos S., Ford, Kyle, Tan, Bing, Zhang, Michelle, McGovern, Karen, Coma, Silvia, Kumada, Yoichi, Yamany, Mena Sameh, Sentandreu, Enrique, Fromm, George, Tiziani, Stefano, Schreiber, Taylor H., Manfredi, Mark, Ehrlich, Lauren I. R., Stone, Everett, Georgiou, George
Publicado 2018