Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS)

por Pozzi, Cecilia, Lopresti, Ludovica, Tassone, Giusy, Mangani, Stefano
Publicado 2019

Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP(+)/NADPH and the substrate folic acid

por Dello Iacono, Lucia, Di Pisa, Flavio, Mangani, Stefano
Publicado 2022

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

por Pozzi, Cecilia, Ferrari, Stefania, Luciani, Rosaria, Costi, Maria Paola, Mangani, Stefano
Publicado 2019

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R

por Pozzi, Cecilia, Lopresti, Ludovica, Santucci, Matteo, Costi, Maria Paola, Mangani, Stefano
Publicado 2019

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Va...

por Pozzi, Cecilia, Ferrari, Stefania, Luciani, Rosaria, Tassone, Giusy, Costi, Maria Paola, Mangani, Stefano
Publicado 2019

Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor

por Tassone, Giusy, Mazzorana, Marco, Mangani, Stefano, Petricci, Elena, Cini, Elena, Giannini, Giuseppe, Pozzi, Cecilia, Maramai, Samuele
Publicado 2022

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase

por Tassone, Giusy, Landi, Giacomo, Linciano, Pasquale, Francesconi, Valeria, Tonelli, Michele, Tagliazucchi, Lorenzo, Costi, Maria Paola, Mangani, Stefano, Pozzi, Cecilia
Publicado 2021

On Nature’s Strategy for Assigning Genetic Code Multiplicity

por Gardini, Simone, Cheli, Sara, Baroni, Silvia, Di Lascio, Gabriele, Mangiavacchi, Guido, Micheletti, Nicholas, Monaco, Carmen Luigia, Savini, Lorenzo, Alocci, Davide, Mangani, Stefano, Niccolai, Neri
Publicado 2016

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

por Santucci, Matteo, Luciani, Rosaria, Gianquinto, Eleonora, Pozzi, Cecilia, Pisa, Flavio di, dello Iacono, Lucia, Landi, Giacomo, Tagliazucchi, Lorenzo, Mangani, Stefano, Spyrakis, Francesca, Costi, Maria Paola
Publicado 2021

Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

por Pozzi, Cecilia, Santucci, Matteo, Marverti, Gaetano, D’Arca, Domenico, Tagliazucchi, Lorenzo, Ferrari, Stefania, Gozzi, Gaia, Losi, Lorena, Tassone, Giusy, Mangani, Stefano, Ponterini, Glauco, Costi, Maria Paola
Publicado 2021

Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment

por Bacchella, Chiara, Camponeschi, Francesca, Kolkowska, Paulina, Kola, Arian, Tessari, Isabella, Baratto, Maria Camilla, Bisaglia, Marco, Monzani, Enrico, Bubacco, Luigi, Mangani, Stefano, Casella, Luigi, Dell’Acqua, Simone, Valensin, Daniela
Publicado 2023

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

por Liu, Bin, Trout, Robert E. Lee, Chu, Guo-Hua, McGarry, Daniel, Jackson, Randy W., Hamrick, Jodie C., Daigle, Denis M., Cusick, Susan M., Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Docquier, Jean-Denis, Weiss, William J., Pevear, Daniel C., Xerri, Luigi, Burns, Christopher J.
Publicado 2019

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

por Pöhner, Ina, Quotadamo, Antonio, Panecka-Hofman, Joanna, Luciani, Rosaria, Santucci, Matteo, Linciano, Pasquale, Landi, Giacomo, Di Pisa, Flavio, Dello Iacono, Lucia, Pozzi, Cecilia, Mangani, Stefano, Gul, Sheraz, Witt, Gesa, Ellinger, Bernhard, Kuzikov, Maria, Santarem, Nuno, Cordeiro-da-Silva, Anabela, Costi, Maria P., Venturelli, Alberto, Wade, Rebecca C.
Publicado 2022

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity

por Di Pisa, Flavio, Landi, Giacomo, Dello Iacono, Lucia, Pozzi, Cecilia, Borsari, Chiara, Ferrari, Stefania, Santucci, Matteo, Santarem, Nuno, Cordeiro-da-Silva, Anabela, Moraes, Carolina B., Alcantara, Laura M., Fontana, Vanessa, Freitas-Junior, Lucio H., Gul, Sheraz, Kuzikov, Maria, Behrens, Birte, Pöhner, Ina, Wade, Rebecca C., Costi, Maria Paola, Mangani, Stefano
Publicado 2017

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa

por Hamrick, Jodie C., Docquier, Jean-Denis, Uehara, Tsuyoshi, Myers, Cullen L., Six, David A., Chatwin, Cassandra L., John, Kaitlyn J., Vernacchio, Salvador F., Cusick, Susan M., Trout, Robert E. L., Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Liu, Bin, Jackson, Randy W., Moeck, Greg, Xerri, Luigi, Burns, Christopher J., Pevear, Daniel C., Daigle, Denis M.
Publicado 2020

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display E...

por Leiris, Simon, Coelho, Alicia, Castandet, Jérôme, Bayet, Maëlle, Lozano, Clarisse, Bougnon, Juliette, Bousquet, Justine, Everett, Martin, Lemonnier, Marc, Sprynski, Nicolas, Zalacain, Magdalena, Pallin, Thomas David, Cramp, Michael C., Jennings, Neil, Raphy, Gilles, Jones, Mark W., Pattipati, Ramesh, Shankar, Battu, Sivasubrahmanyam, Relangi, Soodhagani, Ashok K., Juventhala, Ramakrishna R., Pottabathini, Narender, Pothukanuri, Srinivasu, Benvenuti, Manuela, Pozzi, Cecilia, Mangani, Stefano, De Luca, Filomena, Cerboni, Giulia, Docquier, Jean-Denis, Davies, David T.
Publicado 2018

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

por Linciano, Pasquale, Dawson, Alice, Pöhner, Ina, Costa, David M., Sá, Monica S., Cordeiro-da-Silva, Anabela, Luciani, Rosaria, Gul, Sheraz, Witt, Gesa, Ellinger, Bernhard, Kuzikov, Maria, Gribbon, Philip, Reinshagen, Jeanette, Wolf, Markus, Behrens, Birte, Hannaert, Véronique, Michels, Paul A. M., Nerini, Erika, Pozzi, Cecilia, di Pisa, Flavio, Landi, Giacomo, Santarem, Nuno, Ferrari, Stefania, Saxena, Puneet, Lazzari, Sandra, Cannazza, Giuseppe, Freitas-Junior, Lucio H., Moraes, Carolina B., Pascoalino, Bruno S., Alcântara, Laura M., Bertolacini, Claudia P., Fontana, Vanessa, Wittig, Ulrike, Müller, Wolfgang, Wade, Rebecca C., Hunter, William N., Mangani, Stefano, Costantino, Luca, Costi, Maria P.
Publicado 2017

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

por Costantino, Luca, Ferrari, Stefania, Santucci, Matteo, Salo-Ahen, Outi MH, Carosati, Emanuele, Franchini, Silvia, Lauriola, Angela, Pozzi, Cecilia, Trande, Matteo, Gozzi, Gaia, Saxena, Puneet, Cannazza, Giuseppe, Losi, Lorena, Cardinale, Daniela, Venturelli, Alberto, Quotadamo, Antonio, Linciano, Pasquale, Tagliazucchi, Lorenzo, Moschella, Maria Gaetana, Guerrini, Remo, Pacifico, Salvatore, Luciani, Rosaria, Genovese, Filippo, Henrich, Stefan, Alboni, Silvia, Santarem, Nuno, da Silva Cordeiro, Anabela, Giovannetti, Elisa, Peters, Godefridus J, Pinton, Paolo, Rimessi, Alessandro, Cruciani, Gabriele, Stroud, Robert M, Wade, Rebecca C, Mangani, Stefano, Marverti, Gaetano, D'Arca, Domenico, Ponterini, Glauco, Costi, Maria Paola
Publicado 2022

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

por Moraes, Carolina B., Witt, Gesa, Kuzikov, Maria, Ellinger, Bernhard, Calogeropoulou, Theodora, Prousis, Kyriakos C., Mangani, Stefano, Di Pisa, Flavio, Landi, Giacomo, Iacono, Lucia Dello, Pozzi, Cecilia, Freitas-Junior, Lucio H., dos Santos Pascoalino, Bruno, Bertolacini, Claudia P., Behrens, Birte, Keminer, Oliver, Leu, Jennifer, Wolf, Markus, Reinshagen, Jeanette, Cordeiro-da-Silva, Anabela, Santarem, Nuno, Venturelli, Alberto, Wrigley, Stephen, Karunakaran, Deepa, Kebede, Bethlehem, Pöhner, Ina, Müller, Wolfgang, Panecka-Hofman, Joanna, Wade, Rebecca C., Fenske, Martina, Clos, Joachim, Alunda, José María, Corral, María Jesús, Uliassi, Elisa, Bolognesi, Maria Laura, Linciano, Pasquale, Quotadamo, Antonio, Ferrari, Stefania, Santucci, Matteo, Borsari, Chiara, Costi, Maria Paola, Gul, Sheraz
Publicado 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

por Vanden Eynde, Jean Jacques, Mangoni, Arduino A., Rautio, Jarkko, Leprince, Jérôme, Azuma, Yasu-Taka, García-Sosa, Alfonso T., Hulme, Christopher, Jampilek, Josef, Karaman, Rafik, Li, Wei, Gomes, Paula A. C., Hadjipavlou-Litina, Dimitra, Capasso, Raffaele, Geronikaki, Athina, Cerchia, Laura, Sabatier, Jean-Marc, Ragno, Rino, Tuccinardi, Tiziano, Trabocchi, Andrea, Winum, Jean-Yves, Luque, F. Javier, Prokai-Tatrai, Katalin, Spetea, Mariana, Gütschow, Michael, Kosalec, Ivan, Guillou, Catherine, Vasconcelos, M. Helena, Kokotos, George, Rastelli, Giulio, de Sousa, Maria Emília, Manera, Clementina, Gemma, Sandra, Mangani, Stefano, Siciliano, Carlo, Galdiero, Stefania, Liu, Hong, Scott, Peter J. H., de los Ríos, Cristóbal, Agrofoglio, Luigi A., Collina, Simona, Guedes, Rita C., Muñoz-Torrero, Diego
Publicado 2019