Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease

por Delre, Pietro, Caporuscio, Fabiana, Saviano, Michele, Mangiatordi, Giuseppe Felice
Publicado 2020

Human Aquaporin-4 and Molecular Modeling: Historical Perspective and View to the Future

por Mangiatordi, Giuseppe Felice, Alberga, Domenico, Trisciuzzi, Daniela, Lattanzi, Gianluca, Nicolotti, Orazio
Publicado 2016

A generalizable definition of chemical similarity for read-across

por Floris, Matteo, Manganaro, Alberto, Nicolotti, Orazio, Medda, Ricardo, Mangiatordi, Giuseppe Felice, Benfenati, Emilio
Publicado 2014

A Comparative Molecular Dynamics Study of Selected Point Mutations in the Shwachman–Bodian–Diamond Syndrome Protein SBDS

por Spinetti, Elena, Delre, Pietro, Saviano, Michele, Siliqi, Dritan, Lattanzi, Gianluca, Mangiatordi, Giuseppe Felice
Publicado 2022

Structural Characterization of the Full-Length Anti-CD20 Antibody Rituximab

por Belviso, Benny Danilo, Mangiatordi, Giuseppe Felice, Alberga, Domenico, Mangini, Vincenzo, Carrozzini, Benedetta, Caliandro, Rocco
Publicado 2022

Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study

por Creanza, Teresa Maria, Delre, Pietro, Ancona, Nicola, Lentini, Giovanni, Saviano, Michele, Mangiatordi, Giuseppe Felice
Publicado 2021

GENERA: A Combined Genetic/Deep-Learning Algorithm for Multiobjective Target-Oriented De Novo Design

por Lamanna, Giuseppe, Delre, Pietro, Marcou, Gilles, Saviano, Michele, Varnek, Alexandre, Horvath, Dragos, Mangiatordi, Giuseppe Felice
Publicado 2023

Accelerating Drug Discovery by Early Protein Drug Target Prediction Based on a Multi-Fingerprint Similarity Search †

por Montaruli, Michele, Alberga, Domenico, Ciriaco, Fulvio, Trisciuzzi, Daniela, Tondo, Anna Rita, Mangiatordi, Giuseppe Felice, Nicolotti, Orazio
Publicado 2019

More Is Always Better Than One: The N-Terminal Domain of the Spike Protein as Another Emerging Target for Hampering the SARS-CoV-2 Attachment to Host Cells

por Di Gaetano, Sonia, Capasso, Domenica, Delre, Pietro, Pirone, Luciano, Saviano, Michele, Pedone, Emilia, Mangiatordi, Giuseppe Felice
Publicado 2021

Surface Plasmon Resonance Assay for Label-Free and Selective Detection of HIV-1 p24 Protein

por Sarcina, Lucia, Mangiatordi, Giuseppe Felice, Torricelli, Fabrizio, Bollella, Paolo, Gounani, Zahra, Österbacka, Ronald, Macchia, Eleonora, Torsi, Luisa
Publicado 2021

Why a Diffusing Single‐Molecule can be Detected in Few Minutes by a Large Capturing Bioelectronic Interface

por Macchia, Eleonora, De Caro, Liberato, Torricelli, Fabrizio, Franco, Cinzia Di, Mangiatordi, Giuseppe Felice, Scamarcio, Gaetano, Torsi, Luisa
Publicado 2022

Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques

por Delre, Pietro, Lavado, Giovanna J., Lamanna, Giuseppe, Saviano, Michele, Roncaglioni, Alessandra, Benfenati, Emilio, Mangiatordi, Giuseppe Felice, Gadaleta, Domenico
Publicado 2022

New Insights into the Behavior of NHC-Gold Complexes in Cancer Cells

por Augello, Giuseppa, Azzolina, Antonina, Rossi, Filomena, Prencipe, Filippo, Mangiatordi, Giuseppe Felice, Saviano, Michele, Ronga, Luisa, Cervello, Melchiorre, Tesauro, Diego
Publicado 2023

Single-molecule detection with a millimetre-sized transistor

por Macchia, Eleonora, Manoli, Kyriaki, Holzer, Brigitte, Di Franco, Cinzia, Ghittorelli, Matteo, Torricelli, Fabrizio, Alberga, Domenico, Mangiatordi, Giuseppe Felice, Palazzo, Gerardo, Scamarcio, Gaetano, Torsi, Luisa
Publicado 2018

Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

por Pisani, Leonardo, Farina, Roberta, Soto-Otero, Ramon, Denora, Nunzio, Mangiatordi, Giuseppe Felice, Nicolotti, Orazio, Mendez-Alvarez, Estefania, Altomare, Cosimo Damiano, Catto, Marco, Carotti, Angelo
Publicado 2016

Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis

por Blasi, Davide, Sarcina, Lucia, Tricase, Angelo, Stefanachi, Angela, Leonetti, Francesco, Alberga, Domenico, Mangiatordi, Giuseppe Felice, Manoli, Kyriaki, Scamarcio, Gaetano, Picca, Rosaria Anna, Torsi, Luisa
Publicado 2020

Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective

por Mangiatordi, Giuseppe Felice, Cavalluzzi, Maria Maddalena, Delre, Pietro, Lamanna, Giuseppe, Lumuscio, Maria Cristina, Saviano, Michele, Majoral, Jean-Pierre, Mignani, Serge, Duranti, Andrea, Lentini, Giovanni
Publicado 2023

Silver (I) N-Heterocyclic Carbene Complexes: A Winning and Broad Spectrum of Antimicrobial Properties

por Prencipe, Filippo, Zanfardino, Anna, Di Napoli, Michela, Rossi, Filomena, D’Errico, Stefano, Piccialli, Gennaro, Mangiatordi, Giuseppe Felice, Saviano, Michele, Ronga, Luisa, Varcamonti, Mario, Tesauro, Diego
Publicado 2021

Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-...

por Abatematteo, Francesca Serena, Majellaro, Maria, Montsch, Bianca, Prieto-Díaz, Rubén, Niso, Mauro, Contino, Marialessandra, Stefanachi, Angela, Riganti, Chiara, Mangiatordi, Giuseppe Felice, Delre, Pietro, Heffeter, Petra, Sotelo, Eddy, Abate, Carmen
Publicado 2023

A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach

por Abatematteo, Francesca Serena, Delre, Pietro, Mercurio, Ivan, Rezelj, Veronica V., Siliqi, Dritan, Beaucourt, Stephanie, Lattanzi, Gianluca, Colabufo, Nicola Antonio, Leopoldo, Marcello, Saviano, Michele, Vignuzzi, Marco, Mangiatordi, Giuseppe Felice, Abate, Carmen
Publicado 2023