Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro

por Ozawa, Daisaku, Nomura, Ryo, Mangione, P. Patrizia, Hasegawa, Kazuhiro, Okoshi, Tadakazu, Porcari, Riccardo, Bellotti, Vittorio, Naiki, Hironobu
Publicado 2016

Calcium Binds to Transthyretin with Low Affinity

por Cantarutti, Cristina, Mimmi, Maria Chiara, Verona, Guglielmo, Mandaliti, Walter, Taylor, Graham W., Mangione, P. Patrizia, Giorgetti, Sofia, Bellotti, Vittorio, Corazza, Alessandra
Publicado 2022

Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein

por Moura, Alexandra, Nocerino, Paola, Gilbertson, Janet A., Rendell, Nigel B., Mangione, P. Patrizia, Verona, Guglielmo, Rowczenio, Dorota, Gillmore, Julian D., Taylor, Graham W., Bellotti, Vittorio, Canetti, Diana
Publicado 2020

Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes

por Corazza, Alessandra, Verona, Guglielmo, Waudby, Christopher A., Mangione, P. Patrizia, Bingham, Ryan, Uings, Iain, Canetti, Diana, Nocerino, Paola, Taylor, Graham W., Pepys, Mark B., Christodoulou, John, Bellotti, Vittorio
Publicado 2019

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel

por Verona, Guglielmo, Mangione, P. Patrizia, Raimondi, Sara, Giorgetti, Sofia, Faravelli, Giulia, Porcari, Riccardo, Corazza, Alessandra, Gillmore, Julian D., Hawkins, Philip N., Pepys, Mark B., Taylor, Graham W., Bellotti, Vittorio
Publicado 2017

Co-fibrillogenesis of Wild-type and D76N β(2)-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS

por Natalello, Antonino, Mangione, P. Patrizia, Giorgetti, Sofia, Porcari, Riccardo, Marchese, Loredana, Zorzoli, Irene, Relini, Annalisa, Ami, Diletta, Faravelli, Giulia, Valli, Maurizia, Stoppini, Monica, Doglia, Silvia M., Bellotti, Vittorio, Raimondi, Sara
Publicado 2016

Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis

por Taylor, Graham W., Gilbertson, Janet A., Sayed, Rabya, Blanco, Angel, Rendell, Nigel B., Rowczenio, Dorota, Rezk, Tamer, Mangione, P. Patrizia, Canetti, Diana, Bass, Paul, Hawkins, Philip N., Gillmore, Julian D.
Publicado 2019

Human wild‐type and D76N β(2)‐microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans

por Raimondi, Sara, Faravelli, Giulia, Nocerino, Paola, Mondani, Valentina, Baruffaldi, Alma, Marchese, Loredana, Mimmi, Maria Chiara, Canetti, Diana, Verona, Guglielmo, Caterino, Marianna, Ruoppolo, Margherita, Mangione, P. Patrizia, Bellotti, Vittorio, Lavatelli, Francesca, Giorgetti, Sofia
Publicado 2023

Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms

por Faravelli, Giulia, Mondani, Valentina, Mangione, P. Patrizia, Raimondi, Sara, Marchese, Loredana, Lavatelli, Francesca, Stoppini, Monica, Corazza, Alessandra, Canetti, Diana, Verona, Guglielmo, Obici, Laura, Taylor, Graham W., Gillmore, Julian D., Giorgetti, Sofia, Bellotti, Vittorio
Publicado 2022

The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis

por Rezk, Tamer, Gilbertson, Janet A, Mangione, P Patrizia, Rowczenio, Dorota, Rendell, Nigel B, Canetti, Diana, Lachmann, Helen J, Wechalekar, Ashutosh D, Bass, Paul, Hawkins, Philip N, Bellotti, Vittorio, Taylor, Graham W, Gillmore, Julian D
Publicado 2019

C. elegans expressing D76N β(2)-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

por Faravelli, Giulia, Raimondi, Sara, Marchese, Loredana, Partridge, Frederick A., Soria, Cristina, Mangione, P. Patrizia, Canetti, Diana, Perni, Michele, Aprile, Francesco A., Zorzoli, Irene, Di Schiavi, Elia, Lomas, David A., Bellotti, Vittorio, Sattelle, David B., Giorgetti, Sofia
Publicado 2019

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β(2)-Microglobulin

por Halabelian, Levon, Ricagno, Stefano, Giorgetti, Sofia, Santambrogio, Carlo, Barbiroli, Alberto, Pellegrino, Sara, Achour, Adnane, Grandori, Rita, Marchese, Loredana, Raimondi, Sara, Mangione, P. Patrizia, Esposito, Gennaro, Al-Shawi, Raya, Simons, J. Paul, Speck, Ivana, Stoppini, Monica, Bolognesi, Martino, Bellotti, Vittorio
Publicado 2014

Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies

por Mangione, P. Patrizia, Mazza, Giuseppe, Gilbertson, Janet A., Rendell, Nigel B., Canetti, Diana, Giorgetti, Sofia, Frenguelli, Luca, Curti, Marco, Rezk, Tamer, Raimondi, Sara, Pepys, Mark B., Hawkins, Philip N., Gillmore, Julian D., Taylor, Graham W., Pinzani, Massimo, Bellotti, Vittorio
Publicado 2017

Amyloid persistence in decellularized liver: biochemical and histopathological characterization

por Mazza, Giuseppe, Simons, J. Paul, Al-Shawi, Raya, Ellmerich, Stephan, Urbani, Luca, Giorgetti, Sofia, Taylor, Graham W., Gilbertson, Janet A., Hall, Andrew R., Al-Akkad, Walid, Dhar, Dipok, Hawkins, Philip N., De Coppi, Paolo, Pinzani, Massimo, Bellotti, Vittorio, Mangione, P. Patrizia
Publicado 2016

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

por Porcari, Riccardo, Proukakis, Christos, Waudby, Christopher A., Bolognesi, Benedetta, Mangione, P. Patrizia, Paton, Jack F. S., Mullin, Stephen, Cabrita, Lisa D., Penco, Amanda, Relini, Annalisa, Verona, Guglielmo, Vendruscolo, Michele, Stoppini, Monica, Tartaglia, Gian Gaetano, Camilloni, Carlo, Christodoulou, John, Schapira, Anthony H. V., Bellotti, Vittorio
Publicado 2015

Clinical ApoA‐IV amyloid is associated with fibrillogenic signal sequence

por Canetti, Diana, Nocerino, Paola, Rendell, Nigel B, Botcher, Nicola, Gilbertson, Janet A, Blanco, Angel, Rowczenio, Dorota, Morelli, Alessandra, Mangione, P Patrizia, Corazza, Alessandra, Verona, Guglielmo, Giorgetti, Sofia, Marchese, Loredana, Westermark, Per, Hawkins, Philip N, Gillmore, Julian D, Bellotti, Vittorio, Taylor, Graham W
Publicado 2021

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

por Marcoux, Julien, Mangione, P Patrizia, Porcari, Riccardo, Degiacomi, Matteo T, Verona, Guglielmo, Taylor, Graham W, Giorgetti, Sofia, Raimondi, Sara, Sanglier-Cianférani, Sarah, Benesch, Justin LP, Cecconi, Ciro, Naqvi, Mohsin M, Gillmore, Julian D, Hawkins, Philip N, Stoppini, Monica, Robinson, Carol V, Pepys, Mark B, Bellotti, Vittorio
Publicado 2015

Plasminogen activation triggers transthyretin amyloidogenesis in vitro

por Mangione, P. Patrizia, Verona, Guglielmo, Corazza, Alessandra, Marcoux, Julien, Canetti, Diana, Giorgetti, Sofia, Raimondi, Sara, Stoppini, Monica, Esposito, Marilena, Relini, Annalisa, Canale, Claudio, Valli, Maurizia, Marchese, Loredana, Faravelli, Giulia, Obici, Laura, Hawkins, Philip N., Taylor, Graham W., Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio
Publicado 2018

Bifunctional crosslinking ligands for transthyretin

por Mangione, P. Patrizia, Deroo, Stéphanie, Ellmerich, Stephan, Bellotti, Vittorio, Kolstoe, Simon, Wood, Stephen P., Robinson, Carol V., Smith, Martin D., Tennent, Glenys A., Broadbridge, Robert J., Council, Claire E., Thurston, Joanne R., Steadman, Victoria A., Vong, Antonio K., Swain, Christopher J., Pepys, Mark B., Taylor, Graham W.
Publicado 2015

Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis

por Slamova, Ivana, Adib, Rozita, Ellmerich, Stephan, Golos, Michal R., Gilbertson, Janet A., Botcher, Nicola, Canetti, Diana, Taylor, Graham W., Rendell, Nigel, Tennent, Glenys A., Verona, Guglielmo, Porcari, Riccardo, Mangione, P. Patrizia, Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio, Hawkins, Philip N., Al-Shawi, Raya, Simons, J. Paul
Publicado 2021