Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling

por Barsi-Rhyne, Benjamin, Manglik, Aashish, von Zastrow, Mark
Publicado 2022

Fusion protein strategies for cryo-EM study of G protein-coupled receptors

por Zhang, Kaihua, Wu, Hao, Hoppe, Nicholas, Manglik, Aashish, Cheng, Yifan
Publicado 2022

Applications of molecular replacement to G protein-coupled receptors

por Kruse, Andrew C., Manglik, Aashish, Kobilka, Brian K., Weis, William I.
Publicado 2013

β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19

por Manglik, Aashish, Wingler, Laura M., Rockman, Howard A., Lefkowitz, Robert J.
Publicado 2020

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor

por Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, Traynor, John R
Publicado 2018

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

por Stoeber, Miriam, Jullié, Damien, Li, Joy, Chakraborty, Soumen, Majumdar, Susruta, Lambert, Nevin A, Manglik, Aashish, von Zastrow, Mark
Publicado 2020

Structure of the δ-opioid receptor bound to naltrindole

por Granier, Sébastien, Manglik, Aashish, Kruse, Andrew C., Kobilka, Tong Sun, Thian, Foon Sun, Weis, William I., Kobilka, Brian K.
Publicado 2012

Adrenaline-activated structure of the β(2)-adrenoceptor stabilized by an engineered nanobody

por Ring, Aaron M., Manglik, Aashish, Kruse, Andrew C., Enos, Michael D., Weis, William I., Garcia, K. Christopher, Kobilka, Brian K.
Publicado 2013

Protein design and variant prediction using autoregressive generative models

por Shin, Jung-Eun, Riesselman, Adam J., Kollasch, Aaron W., McMahon, Conor, Simon, Elana, Sander, Chris, Manglik, Aashish, Kruse, Andrew C., Marks, Debora S.
Publicado 2021

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

por Billesbølle, Christian B., Azumaya, Caleigh M., Kretsch, Rachael C., Powers, Alexander S., Gonen, Shane, Schneider, Simon, Arvedson, Tara, Dror, Ron O., Cheng, Yifan, Manglik, Aashish
Publicado 2020

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

por Maeda, Shoji, Koehl, Antoine, Matile, Hugues, Hu, Hongli, Hilger, Daniel, Schertler, Gebhard F. X., Manglik, Aashish, Skiniotis, Georgios, Dawson, Roger J. P., Kobilka, Brian K.
Publicado 2018

Crystal structure of the μ-opioid receptor bound to a morphinan antagonist

por Manglik, Aashish, Kruse, Andrew C., Kobilka, Tong Sun, Thian, Foon Sun, Mathiesen, Jesper M., Sunahara, Roger K., Pardo, Leonardo, Weis, William I., Kobilka, Brian K., Granier, Sébastien
Publicado 2012

Selective G protein signaling driven by Substance P-Neurokinin Receptor dynamics

por Harris, Julian A., Faust, Bryan, Gondin, Arisbel B., Dämgen, Marc André, Suomivuori, Carl-Mikael, Veldhuis, Nicholas A., Cheng, Yifan, Dror, Ron O., Thal, David M., Manglik, Aashish
Publicado 2021

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

por McMahon, Conor, Baier, Alexander S., Pascolutti, Roberta, Wegrecki, Marcin, Zheng, Sanduo, Ong, Janice X., Erlandson, Sarah C., Hilger, Daniel, Rasmussen, Søren G. F., Ring, Aaron M., Manglik, Aashish, Kruse, Andrew C.
Publicado 2018

Rare antibody phage isolation and discrimination (RAPID) biopanning enables identification of high-affinity antibodies against challenging targets

por Chung, Dong hee, Kong, Sophie, Young, Nicholas J., Chuo, Shih-Wei, Shiah, Jamie V., Connelly, Emily J., Rohweder, Peter J., Born, Alexandra, Manglik, Aashish, Grandis, Jennifer R., Johnson, Daniel E., Craik, Charles S.
Publicado 2023

Engineered odorant receptors illuminate structural principles of odor discrimination

por de March, Claire A., Ma, Ning, Billesbølle, Christian B., Tewari, Jeevan, del Torrent, Claudia Llinas, van der Velden, Wijnand J. C., Ojiro, Ichie, Takayama, Ikumi, Faust, Bryan, Li, Linus, Vaidehi, Nagarajan, Manglik, Aashish, Matsunami, Hiroaki
Publicado 2023

Allosteric coupling from G protein to the agonist binding pocket in GPCRs

por DeVree, Brian T., Mahoney, Jacob P., Vélez-Ruiz, Gisselle A., Rasmussen, Soren G.F., Kuszak, Adam J., Edwald, Elin, Fung, Juan-Jose, Manglik, Aashish, Masureel, Matthieu, Du, Yang, Matt, Rachel A, Pardon, Els, Steyaert, Jan, Kobilka, Brian K., Sunahara, Roger K.
Publicado 2016

Structure of the μ Opioid Receptor-G(i) Protein Complex

por Koehl, Antoine, Hu, Hongli, Maeda, Shoji, Zhang, Yan, Qu, Qianhui, Paggi, Joseph M., Latorraca, Naomi R., Hilger, Daniel, Dawson, Roger, Matile, Hugues, Schertler, Gebhard F. X., Granier, Sebastien, Weis, William I., Dror, Ron O., Manglik, Aashish, Skiniotis, Georgios, Kobilka, Brian K.
Publicado 2018

Activation and allosteric modulation of a muscarinic acetylcholine receptor

por Kruse, Andrew C., Ring, Aaron M., Manglik, Aashish, Hu, Jianxin, Hu, Kelly, Eitel, Katrin, Hübner, Harald, Pardon, Els, Valant, Celine, Sexton, Patrick M., Christopoulos, Arthur, Felder, Christian C., Gmeiner, Peter, Steyaert, Jan, Weis, William I., Garcia, K. Christopher, Wess, Jürgen, Kobilka, Brian K.
Publicado 2013

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

por Hoppe, Nicholas, Harrison, Simone, Hwang, Sun-Hee, Chen, Ziwei, Karelina, Masha, Deshpande, Ishan, Suomivuori, Carl-Mikael, Palicharla, Vivek R., Berry, Samuel P., Tschaikner, Philipp, Regele, Dominik, Covey, Douglas F., Stefan, Eduard, Marks, Debora S., Reiter, Jeremy, Dror, Ron O., Evers, Alex S., Mukhopadhyay, Saikat, Manglik, Aashish
Publicado 2023