Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex

por Kim, Yoori, Furman, Christopher M, Manhart, Carol M, Alani, Eric, Finkelstein, Ilya J
Publicado 2019

The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension

por Witte, Scott J, Rosa, Isabella M, Collingwood, Bryce W, Piscitelli, Jonathan M, Manhart, Carol M
Publicado 2023

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans

por Manhart, Carol M., Ni, Xiaodan, White, Martin A., Ortega, Joaquin, Surtees, Jennifer A., Alani, Eric
Publicado 2017

Bacteriophage SPP1 DNA replication strategies promote viral and disable host replication in vitro

por Seco, Elena M., Zinder, John C., Manhart, Carol M., Lo Piano, Ambra, McHenry, Charles S., Ayora, Silvia
Publicado 2013

mlh3 mutations in baker’s yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide

por Al-Sweel, Najla, Raghavan, Vandana, Dutta, Abhishek, Ajith, V. P., Di Vietro, Luigi, Khondakar, Nabila, Manhart, Carol M., Surtees, Jennifer A., Nishant, K. T., Alani, Eric
Publicado 2017

Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis

por Gioia, Michael, Payero, Lisette, Salim, Sagar, Fajish V., Ghanim, Farnaz, Amamah F., Pannafino, Gianno, Chen, Jun Jie, Ajith, V. P., Momoh, Sherikat, Scotland, Michelle, Raghavan, Vandana, Manhart, Carol M., Shinohara, Akira, Nishant, K. T., Alani, Eric
Publicado 2023