Frame-shifted proteins of a given gene are unlikely to retain the same function

por Mankin, Alexander S.
Publicado 2020

Editorial: Ribosome survey and summary collection 2020

por Dunham, Christine M, Dynan, William S, Mankin, Alexander
Publicado 2020

Structural signatures of antibiotic binding sites on the ribosome

por David-Eden, Hilda, Mankin, Alexander S., Mandel-Gutfreund, Yael
Publicado 2010

A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria

por Svetlov, Maxim S., Cohen, Sophie, Alsuhebany, Nada, Vázquez-Laslop, Nora, Mankin, Alexander S.
Publicado 2020

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

por Orelle, Cédric, Szal, Teresa, Klepacki, Dorota, Shaw, Karen J., Vázquez-Laslop, Nora, Mankin, Alexander S.
Publicado 2013

Nascent peptide assists the ribosome in recognizing chemically distinct small molecules

por Gupta, Pulkit, Liu, Bo, Klepacki, Dorota, Gupta, Vrinda, Schulten, Klaus, Mankin, Alexander S., Vázquez-Laslop, Nora
Publicado 2016

Nucleotide Biosynthesis Is Critical for Growth of Bacteria in Human Blood

por Samant, Shalaka, Lee, Hyunwoo, Ghassemi, Mahmood, Chen, Juan, Cook, James L, Mankin, Alexander S, Neyfakh, Alexander A
Publicado 2008

Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition

por Gagnon, Matthieu G., Roy, Raktim N., Lomakin, Ivan B., Florin, Tanja, Mankin, Alexander S., Steitz, Thomas A.
Publicado 2016

Chemical engineering of the peptidyl transferase center reveals an important role of the 2′-hydroxyl group of A2451

por Erlacher, Matthias D., Lang, Kathrin, Shankaran, Nisha, Wotzel, Brigitte, Hüttenhofer, Alexander, Micura, Ronald, Mankin, Alexander S., Polacek, Norbert
Publicado 2005

A fully orthogonal system for protein synthesis in bacterial cells

por Aleksashin, Nikolay A., Szal, Teresa, d’Aquino, Anne E., Jewett, Michael C., Vázquez-Laslop, Nora, Mankin, Alexander S.
Publicado 2020

Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.

por Svetlov, Maxim S., Syroegin, Egor A., Aleksandrova, Elena V., Atkinson, Gemma C., Gregory, Steven T., Mankin, Alexander S., Polikanov, Yury S.
Publicado 2021

The context of the ribosome binding site in mRNAs defines specificity of action of kasugamycin, an inhibitor of translation initiation

por Zhang, Yan, Aleksashin, Nikolay A., Klepacki, Dorota, Anderson, Caleb, Vázquez-Laslop, Nora, Gross, Carol A., Mankin, Alexander S.
Publicado 2022

Dynamics of the context-specific translation arrest by chloramphenicol and linezolid

por Choi, Junhong, Marks, James, Zhang, Jingji, Chen, Dong-Hua, Wang, Jinfan, Vázquez-Laslop, Nora, Mankin, Alexander S., Puglisi, Joseph D.
Publicado 2019

Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria

por Mangano, Kyle, Florin, Tanja, Shao, Xinhao, Klepacki, Dorota, Chelysheva, Irina, Ignatova, Zoya, Gao, Yu, Mankin, Alexander S, Vázquez-Laslop, Nora
Publicado 2020

Discovery of Unannotated Small Open Reading Frames in Streptococcus pneumoniae D39 Involved in Quorum Sensing and Virulence Using Ribosome Profiling

por Laczkovich, Irina, Mangano, Kyle, Shao, Xinhao, Hockenberry, Adam J., Gao, Yu, Mankin, Alexander, Vázquez-Laslop, Nora, Federle, Michael J.
Publicado 2022

Assembly and functionality of the ribosome with tethered subunits

por Aleksashin, Nikolay A., Leppik, Margus, Hockenberry, Adam J., Klepacki, Dorota, Vázquez-Laslop, Nora, Jewett, Michael C., Remme, Jaanus, Mankin, Alexander S.
Publicado 2019

Engineered ribosomes with tethered subunits for expanding biological function

por Carlson, Erik D., d’Aquino, Anne E., Kim, Do Soon, Fulk, Emily M., Hoang, Kim, Szal, Teresa, Mankin, Alexander S., Jewett, Michael C.
Publicado 2019

Context-specific action of macrolide antibiotics on the eukaryotic ribosome

por Svetlov, Maxim S., Koller, Timm O., Meydan, Sezen, Shankar, Vaishnavi, Klepacki, Dorota, Polacek, Norbert, Guydosh, Nicholas R., Vázquez-Laslop, Nora, Wilson, Daniel N., Mankin, Alexander S.
Publicado 2021

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome

por Florin, Tanja, Maracci, Cristina, Graf, Michael, Karki, Prajwal, Klepacki, Dorota, Berninghausen, Otto, Beckmann, Roland, Vázquez-Laslop, Nora, Wilson, Daniel N., Rodnina, Marina V., Mankin, Alexander S.
Publicado 2017

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

por Almutairi, Mashal M., Svetlov, Maxim S., Hansen, Douglas A., Khabibullina, Nelli F., Klepacki, Dorota, Kang, Han-Young, Sherman, David H., Vázquez-Laslop, Nora, Polikanov, Yury S., Mankin, Alexander S.
Publicado 2017