Clinical Efficacy among Patients with Chronic Rhinosinusitis with Nasal Polyps and Clinical Features of Obstructive Lung Disease: Post Hoc Analysis of the Phase III SINUS-24 and SI...

por Maspero, Jorge F, Bachert, Claus, Martinez, Fernando J, Hanania, Nicola A, Ortiz, Benjamin, Patel, Naimish, Mannent, Leda P, Praestgaard, Amy, Pandit-Abid, Nami, Siddiqui, Shahid, Hardin, Megan
Publicado 2023

Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Conce...

por Khan, Asif H, Abbe, Adeline, Falissard, Bruno, Carita, Paulo, Bachert, Claus, Mullol, Joaquim, Reaney, Matthew, Chao, Jingdong, Mannent, Leda P, Amin, Nikhil, Mahajan, Puneet, Pirozzi, Gianluca, Eckert, Laurent
Publicado 2021

Dupilumab improves health related quality of life: Results from the phase 3 SINUS studies

por Lee, Stella E., Hopkins, Claire, Mullol, Joaquim, Msihid, Jérôme, Guillemin, Isabelle, Amin, Nikhil, Mannent, Leda P., Li, Yongtao, Siddiqui, Shahid, Chuang, Chien‐Chia, Kamat, Siddhesh, Khan, Asif H.
Publicado 2022

Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS‐52 is unaffected by eosinophilic status

por Fujieda, Shigeharu, Matsune, Shoji, Takeno, Sachio, Ohta, Nobuo, Asako, Mikiya, Bachert, Claus, Inoue, Tomoyuki, Takahashi, Yoshinori, Fujita, Hiroyuki, Deniz, Yamo, Rowe, Paul, Ortiz, Benjamin, Li, Yongtao, Mannent, Leda P.
Publicado 2021

Effect of Dupilumab on Type 2 Biomarkers in Chronic Rhinosinusitis With Nasal Polyps: SINUS-52 Study Results

por Bachert, Claus, Laidlaw, Tanya M., Cho, Seong H., Mullol, Joaquim, Swanson, Brian N., Naimi, Souad, Classe, Marion, Harel, Sivan, Jagerschmidt, Alexandre, Laws, Elizabeth, Ruddy, Marcella, Praestgaard, Amy, Amin, Nikhil, Mannent, Leda P.
Publicado 2023

Dupilumab in CRSwNP: Responder Analysis Using Clinically Meaningful Efficacy Outcome Thresholds

por Chuang, Chien‐Chia, Guillemin, Isabelle, Bachert, Claus, Lee, Stella E., Hellings, Peter W., Fokkens, Wytske J., Duverger, Nicolas, Fan, Chunpeng, Daizadeh, Nadia, Amin, Nikhil, Mannent, Leda P., Khan, Asif H., Kamat, Siddhesh
Publicado 2021

Efficacy and safety of dupilumab in patients with uncontrolled severe chronic rhinosinusitis with nasal polyps and a clinical diagnosis of NSAID‐ERD: Results from two randomized pl...

por Mullol, Joaquim, Laidlaw, Tanya M., Bachert, Claus, Mannent, Leda P., Canonica, G. Walter, Han, Joseph K., Maspero, Jorge F., Picado, Cesar, Daizadeh, Nadia, Ortiz, Benjamin, Li, Yongtao, Ruddy, Marcella, Laws, Elizabeth, Amin, Nikhil
Publicado 2021

Dupilumab reduces local type 2 pro‐inflammatory biomarkers in chronic rhinosinusitis with nasal polyposis

por Jonstam, Karin, Swanson, Brian N., Mannent, Leda P., Cardell, Lars‐Olaf, Tian, Nian, Wang, Ying, Zhang, Donghui, Fan, Chunpeng, Holtappels, Gabriele, Hamilton, Jennifer D., Grabher, Annette, Graham, Neil M. H., Pirozzi, Gianluca, Bachert, Claus
Publicado 2019

Efficacy of dupilumab in patients with a history of prior sinus surgery for chronic rhinosinusitis with nasal polyps

por Hopkins, Claire, Wagenmann, Martin, Bachert, Claus, Desrosiers, Martin, Han, Joseph K., Hellings, Peter W., Lee, Stella E., Msihid, Jérôme, Radwan, Amr, Rowe, Paul, Amin, Nikhil, Deniz, Yamo, Ortiz, Benjamin, Mannent, Leda P., Rout, Rajesh
Publicado 2021

Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials

por Yosipovitch, Gil, Mollanazar, Nicholas, Ständer, Sonja, Kwatra, Shawn G., Kim, Brian S., Laws, Elizabeth, Mannent, Leda P., Amin, Nikhil, Akinlade, Bolanle, Staudinger, Heribert W., Patel, Naimish, Yancopoulos, George D., Weinreich, David M., Wang, Sheldon, Shi, Genming, Bansal, Ashish, O’Malley, John T.
Publicado 2023

Estimating Clinically Meaningful Change of Efficacy Outcomes in Inadequately Controlled Chronic Rhinosinusitis with Nasal Polyposis

por Han, Joseph K., Bachert, Claus, Lee, Stella E., Hopkins, Claire, Heffler, Enrico, Hellings, Peter W., Peters, Anju T., Kamat, Siddhesh, Whalley, Diane, Qin, Shanshan, Nelson, Lauren, Siddiqui, Shahid, Khan, Asif H., Li, Yongtao, Mannent, Leda P., Guillemin, Isabelle, Chuang, Chien‐Chia
Publicado 2021

Preclinical and clinical experience with dupilumab on the correlates of live attenuated vaccines

por Wechsler, Michael E., Souza-Machado, Adelmir, Xu, Christine, Mao, Xuezhou, Kapoor, Upender, Khokhar, Faisal A., O’Malley, John T., Petro, Christopher D., Casullo, Veronica Mas, Mannent, Leda P., Rowe, Paul J., Jacob-Nara, Juby A., Ruddy, Marcella, Laws, Elizabeth, Purcell, Lisa A., Hardin, Megan
Publicado 2021