Satellite cells delivered in their niche efficiently generate functional myotubes in three-dimensional cell culture

por Prüller, Johanna, Mannhardt, Ingra, Eschenhagen, Thomas, Zammit, Peter S., Figeac, Nicolas
Publicado 2018

Force and Calcium Transients Analysis in Human Engineered Heart Tissues Reveals Positive Force-Frequency Relation at Physiological Frequency

por Saleem, Umber, Mannhardt, Ingra, Braren, Ingke, Denning, Chris, Eschenhagen, Thomas, Hansen, Arne
Publicado 2020

Regulation of I(Ca,L) and force by PDEs in human‐induced pluripotent stem cell‐derived cardiomyocytes

por Saleem, Umber, Ismaili, Djemail, Mannhardt, Ingra, Pinnschmidt, Hans, Schulze, Thomas, Christ, Torsten, Eschenhagen, Thomas, Hansen, Arne
Publicado 2020

Ca(2+)-Currents in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Effects of Two Different Culture Conditions

por Uzun, Ahmet U., Mannhardt, Ingra, Breckwoldt, Kaja, Horváth, András, Johannsen, Silke S., Hansen, Arne, Eschenhagen, Thomas, Christ, Torsten
Publicado 2016

Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats

por Mulla, Wesam, Etzion, Sharon, Elyagon, Sigal, Gillis, Roni, Murninkas, Michael, Konstantino, Yuval, Mannhardt, Ingra, Eschenhagen, Thomas, Liel-Cohen, Noah, Etzion, Yoram
Publicado 2017

Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics

por Bhagwan, Jamie R., Mosqueira, Diogo, Chairez-Cantu, Karolina, Mannhardt, Ingra, Bodbin, Sara E., Bakar, Mine, Smith, James G.W., Denning, Chris
Publicado 2020

Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes

por Ulmer, Bärbel M., Stoehr, Andrea, Schulze, Mirja L., Patel, Sajni, Gucek, Marjan, Mannhardt, Ingra, Funcke, Sandra, Murphy, Elizabeth, Eschenhagen, Thomas, Hansen, Arne
Publicado 2018

Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

por Jacob, Fabian, Yonis, Amina Y., Cuello, Friederike, Luther, Pradeep, Schulze, Thomas, Eder, Alexandra, Streichert, Thomas, Mannhardt, Ingra, Hirt, Marc N., Schaaf, Sebastian, Stenzig, Justus, Force, Thomas, Eschenhagen, Thomas, Hansen, Arne
Publicado 2016

Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae

por Mannhardt, Ingra, Eder, Alexandra, Dumotier, Berengere, Prondzynski, Maksymilian, Krämer, Elisabeth, Traebert, Martin, Söhren, Klaus-Dieter, Flenner, Frederik, Stathopoulou, Konstantina, Lemoine, Marc D., Carrier, Lucie, Christ, Torsten, Eschenhagen, Thomas, Hansen, Arne
Publicado 2017

Correction: Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

por Jacob, Fabian, Yonis, Amina Y., Cuello, Friederike, Luther, Pradeep, Schulze, Thomas, Eder, Alexandra, Streichert, Thomas, Mannhardt, Ingra, Hirt, Marc N., Schaaf, Sebastian, Stenzig, Justus, Force, Thomas, Eschenhagen, Thomas, Hansen, Arne
Publicado 2018

Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes—An Artifact by Big Conductance Calcium Activated Potassium Current (I(bk,Ca))

por Horváth, András, Christ, Torsten, Koivumäki, Jussi T., Prondzynski, Maksymilian, Zech, Antonia T. L., Spohn, Michael, Saleem, Umber, Mannhardt, Ingra, Ulmer, Bärbel, Girdauskas, Evaldas, Meyer, Christian, Hansen, Arne, Eschenhagen, Thomas, Lemoine, Marc D.
Publicado 2020

Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue

por Dutsch, Alexander, Wijnker, Paul J. M., Schlossarek, Saskia, Friedrich, Felix W., Krämer, Elisabeth, Braren, Ingke, Hirt, Marc N., Brenière-Letuffe, David, Rhoden, Alexandra, Mannhardt, Ingra, Eschenhagen, Thomas, Carrier, Lucie, Mearini, Giulia
Publicado 2019

Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density

por Lemoine, Marc D., Mannhardt, Ingra, Breckwoldt, Kaja, Prondzynski, Maksymilian, Flenner, Frederik, Ulmer, Bärbel, Hirt, Marc N., Neuber, Christiane, Horváth, András, Kloth, Benjamin, Reichenspurner, Hermann, Willems, Stephan, Hansen, Arne, Eschenhagen, Thomas, Christ, Torsten
Publicado 2017

Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits

por Smith, James G.W., Owen, Thomas, Bhagwan, Jamie R., Mosqueira, Diogo, Scott, Elizabeth, Mannhardt, Ingra, Patel, Asha, Barriales-Villa, Roberto, Monserrat, Lorenzo, Hansen, Arne, Eschenhagen, Thomas, Harding, Sian E., Marston, Steve, Denning, Chris
Publicado 2018

Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes

por Horváth, András, Lemoine, Marc D., Löser, Alexandra, Mannhardt, Ingra, Flenner, Frederik, Uzun, Ahmet Umur, Neuber, Christiane, Breckwoldt, Kaja, Hansen, Arne, Girdauskas, Evaldas, Reichenspurner, Hermann, Willems, Stephan, Jost, Norbert, Wettwer, Erich, Eschenhagen, Thomas, Christ, Torsten
Publicado 2018

Human Engineered Heart Tissue: Analysis of Contractile Force

por Mannhardt, Ingra, Breckwoldt, Kaja, Letuffe-Brenière, David, Schaaf, Sebastian, Schulz, Herbert, Neuber, Christiane, Benzin, Anika, Werner, Tessa, Eder, Alexandra, Schulze, Thomas, Klampe, Birgit, Christ, Torsten, Hirt, Marc N., Huebner, Norbert, Moretti, Alessandra, Eschenhagen, Thomas, Hansen, Arne
Publicado 2016

Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format

por Mannhardt, Ingra, Saleem, Umber, Mosqueira, Diogo, Loos, Malte F., Ulmer, Bärbel M., Lemoine, Marc D., Larsson, Camilla, Améen, Caroline, de Korte, Tessa, Vlaming, Maria L.H., Harris, Kate, Clements, Peter, Denning, Chris, Hansen, Arne, Eschenhagen, Thomas
Publicado 2020

CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic...

por Mosqueira, Diogo, Mannhardt, Ingra, Bhagwan, Jamie R, Lis-Slimak, Katarzyna, Katili, Puspita, Scott, Elizabeth, Hassan, Mustafa, Prondzynski, Maksymilian, Harmer, Stephen C, Tinker, Andrew, Smith, James G W, Carrier, Lucie, Williams, Philip M, Gaffney, Daniel, Eschenhagen, Thomas, Hansen, Arne, Denning, Chris
Publicado 2018

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering

por Maffioletti, Sara Martina, Sarcar, Shilpita, Henderson, Alexander B.H., Mannhardt, Ingra, Pinton, Luca, Moyle, Louise Anne, Steele-Stallard, Heather, Cappellari, Ornella, Wells, Kim E., Ferrari, Giulia, Mitchell, Jamie S., Tyzack, Giulia E., Kotiadis, Vassilios N., Khedr, Moustafa, Ragazzi, Martina, Wang, Weixin, Duchen, Michael R., Patani, Rickie, Zammit, Peter S., Wells, Dominic J., Eschenhagen, Thomas, Tedesco, Francesco Saverio
Publicado 2018

Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes

por Saleem, Umber, van Meer, Berend J, Katili, Puspita A, Mohd Yusof, Nurul A N, Mannhardt, Ingra, Garcia, Ana Krotenberg, Tertoolen, Leon, de Korte, Tessa, Vlaming, Maria L H, McGlynn, Karen, Nebel, Jessica, Bahinski, Anthony, Harris, Kate, Rossman, Eric, Xu, Xiaoping, Burton, Francis L, Smith, Godfrey L, Clements, Peter, Mummery, Christine L, Eschenhagen, Thomas, Hansen, Arne, Denning, Chris
Publicado 2020