Tolerogenic vaccines for Multiple Sclerosis

por Mannie, Mark D., Curtis, II, Alan D.
Publicado 2013

Cytokine-Neuroantigen Fusion Proteins as a New Class of Tolerogenic, Therapeutic Vaccines for Treatment of Inflammatory Demyelinating Disease in Rodent Models of Multiple Sclerosis

por Mannie, Mark D., Blanchfield, J. Lori, Islam, S. M. Touhidul, Abbott, Derek J.
Publicado 2012

Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25(high) FOXP3(+) Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy

por Wilkinson, Daniel S., Ghosh, Debjani, Nickle, Rebecca A., Moorman, Cody D., Mannie, Mark D.
Publicado 2017

A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4(+) CD25(+) FOXP3(+) Tregs that inhibit e...

por Moorman, Cody D., Bastian, Alexander G., DeOca, Kayla B., Mannie, Mark D.
Publicado 2020

Low-Zone IL-2 Signaling: Fusion Proteins Containing Linked CD25 and IL-2 Domains Sustain Tolerogenic Vaccination in vivo and Promote Dominance of FOXP3(+) Tregs in vitro

por DeOca, Kayla B., Moorman, Cody D., Garcia, Brandon L., Mannie, Mark D.
Publicado 2020

A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4(+) CD25(high) FOXP3(+) Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-...

por Moorman, Cody D., Curtis, Alan D., Bastian, Alexander G., Elliott, Sarah E., Mannie, Mark D.
Publicado 2019

Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of expe...

por Abbott, Derek J, Blanchfield, J Lori, Martinson, David A, Russell, Sean C, Taslim, Najla, Curtis, Alan D, Mannie, Mark D
Publicado 2011

The Extracellular Domain of Myelin Oligodendrocyte Glycoprotein Elicits Atypical Experimental Autoimmune Encephalomyelitis in Rat and Macaque Species

por Curtis, Alan D., Taslim, Najla, Reece, Shaun P., Grebenciucova, Elena, Ray, Richard H., Rosenbaum, Matthew D., Wardle, Robert L., Van Scott, Michael R., Mannie, Mark D.
Publicado 2014