The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

por Mansour, Wael Y., Rhein, Tim, Dahm-Daphi, Jochen
Publicado 2010

5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells

por Oing, Christoph, Verem, Izudin, Mansour, Wael Y., Bokemeyer, Carsten, Dyshlovoy, Sergey, Honecker, Friedemann
Publicado 2018

Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase

por Köcher, Sabrina, Rieckmann, Thorsten, Rohaly, Gabor, Mansour, Wael Y., Dikomey, Ekkehard, Dornreiter, Irena, Dahm-Daphi, Jochen
Publicado 2012

5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair

por Srinivas, Upadhyayula Sai, Dyczkowski, Jerzy, Beißbarth, Tim, Gaedcke, Jochen, Mansour, Wael Y., Borgmann, Kerstin, Dobbelstein, Matthias
Publicado 2015

Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1

por Bakr, Ali, Köcher, Sabrina, Volquardsen, Jennifer, Petersen, Cordula, Borgmann, Kerstin, Dikomey, Ekkehard, Rothkamm, Kai, Mansour, Wael Y.
Publicado 2016

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks

por Mansour, Wael Y., Schumacher, Sabine, Rosskopf, Raphael, Rhein, Tim, Schmidt-Petersen, Filip, Gatzemeier, Fruszina, Haag, Friedrich, Borgmann, Kerstin, Willers, Henning, Dahm-Daphi, Jochen
Publicado 2008

Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer

por Toulany, Mahmoud, Iida, Mari, Keinath, Simone, Iyi, Firdevs F., Mueck, Katharina, Fehrenbacher, Birgit, Mansour, Wael Y., Schaller, Martin, Wheeler, Deric L., Rodemann, H. Peter
Publicado 2016

PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response

por Wurster, Stephanie, Hennes, Fabian, Parplys, Ann C., Seelbach, Jasna I., Mansour, Wael Y., Zielinski, Alexandra, Petersen, Cordula, Clauditz, Till S., Münscher, Adrian, Friedl, Anna A., Borgmann, Kerstin
Publicado 2016

Emerging Insights into Keratin 16 Expression during Metastatic Progression of Breast Cancer

por Elazezy, Maha, Schwentesius, Sandra, Stegat, Luisa, Wikman, Harriet, Werner, Stefan, Mansour, Wael Y., Failla, Antonio Virgilio, Peine, Sven, Müller, Volkmar, Thiery, Jean Paul, Ebrahimi Warkiani, Majid, Pantel, Klaus, Joosse, Simon A.
Publicado 2021

Preclinical patient‐derived modeling of castration‐resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease

por Elsesy, Mohamed E., Oh‐Hohenhorst, Su Jung, Oing, Christoph, Eckhardt, Alicia, Burdak‐Rothkamm, Susanne, Alawi, Malik, Müller, Christian, Schüller, Ulrich, Maurer, Tobias, von Amsberg, Gunhild, Petersen, Cordula, Rothkamm, Kai, Mansour, Wael Y.
Publicado 2023

Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair

por Penterling, Corina, Drexler, Guido A., Böhland, Claudia, Stamp, Ramona, Wilke, Christina, Braselmann, Herbert, Caldwell, Randolph B., Reindl, Judith, Girst, Stefanie, Greubel, Christoph, Siebenwirth, Christian, Mansour, Wael Y., Borgmann, Kerstin, Dollinger, Günther, Unger, Kristian, Friedl, Anna A.
Publicado 2016

Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State through Inhibition of DNA Double Strand Break Repair

por Elsesy, Mohamed E., Oh-Hohenhorst, Su Jung, Löser, Anastassia, Oing, Christoph, Mutiara, Sally, Köcher, Sabrina, Meien, Stefanie, Zielinski, Alexandra, Burdak-Rothkamm, Susanne, Tilki, Derya, Huland, Hartwig, Schwarz, Rudolf, Petersen, Cordula, Bokemeyer, Carsten, Rothkamm, Kai, Mansour, Wael Y.
Publicado 2020

X-ray Fluorescence Uptake Measurement of Functionalized Gold Nanoparticles in Tumor Cell Microsamples

por Schmutzler, Oliver, Graf, Sebastian, Behm, Nils, Mansour, Wael Y., Blumendorf, Florian, Staufer, Theresa, Körnig, Christian, Salah, Dina, Kang, Yanan, Peters, Jan N., Liu, Yang, Feliu, Neus, Parak, Wolfgang J., Burkhardt, Anja, Gargioni, Elisabetta, Gennis, Sabrina, Chandralingam, Sharah, Höeg, Finn, Maison, Wolfgang, Rothkamm, Kai, Schulz, Florian, Grüner, Florian
Publicado 2021

Increased replication stress and R-loop accumulation in EGFRvIII-expressing glioblastoma present new therapeutic opportunities

por Struve, Nina, Hoffer, Konstantin, Weik, Anna-Sophie, Riepen, Britta, Krug, Leonie, Cetin, Meryem H, Burmester, Jasmin, Ott, Leonie, Liebing, Jana, Gatzemeier, Fruzsina, Müller-Goebel, Justus, Gerbach, Mirja, Bußmann, Lara, Parplys, Ann Christin, Unger, Kristian, Mansour, Wael Y, Schüller, Ulrich, Rieckmann, Thorsten, Petersen, Cordula, Rothkamm, Kai, Short, Susan C, Kriegs, Malte
Publicado 2021