Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket

por Manville, Rían W., Abbott, Geoffrey W.
Publicado 2018

In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner

por Manville, Rían W., Abbott, Geoffrey W.
Publicado 2019

The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels

por Manville, Rían W., Abbott, Geoffrey W.
Publicado 2021

Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener

por Manville, Rían W., Hogenkamp, Derk, Abbott, Geoffrey W.
Publicado 2023

Direct neurotransmitter activation of voltage-gated potassium channels

por Manville, Rían W., Papanikolaou, Maria, Abbott, Geoffrey W.
Publicado 2018

Case report: A novel loss-of-function pathogenic variant in the KCNA1 cytoplasmic N-terminus causing carbamazepine-responsive type 1 episodic ataxia

por Manville, Rían W., Sidlow, Richard, Abbott, Geoffrey W.
Publicado 2022

Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation

por De Silva, Angele M., Manville, Rían W., Abbott, Geoffrey W.
Publicado 2018

Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain

por Manville, Rían W., Alfredo Freites, J., Sidlow, Richard, Tobias, Douglas J., Abbott, Geoffrey W.
Publicado 2023

Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations

por Martin-Batista, Elva, Manville, Rían W., Rivero-Pérez, Belinda, Bartolomé-Martín, David, Alvarez de la Rosa, Diego, Abbott, Geoffrey W., Giraldez, Teresa
Publicado 2021

KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics

por Abbott, Geoffrey W., Redford, Kaitlyn E., Yoshimura, Ryan F., Manville, Rían W., Moreira, Luiz, Tran, Kevin, Arena, Grey, Kookootsedes, Alexandra, Lasky, Emma, Gunnison, Elliot
Publicado 2021