Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases

por Gibson, Beth G., Cox, Thomas E., Marchbank, Kevin J.
Publicado 2022

Editorial: Autoantibodies in Kidney Diseases

por Marchbank, Kevin J., Frazer-Abel, Ashley, Dragon-Durey, Marie-Agnes, Dixon, Bradley P.
Publicado 2020

A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL

por Nichols, Eva-Maria, Jones, Rachel, Watson, Rachael, Pepper, Chris J., Fegan, Chris, Marchbank, Kevin J.
Publicado 2015

Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21)

por Pappworth, Isabel Y., Kulik, Liudmila, Haluszczak, Catherine, Reuter, Jason W., Holers, V. Michael, Marchbank, Kevin J.
Publicado 2009

Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice

por Twohig, Jason P., Pappworth, Isabel Y., Sivasankar, Baalasubramanian, Kulik, Liudmila, Bull, Melanie, Holers, V. Michael, Wang, Eddie C.Y., Marchbank, Kevin J.
Publicado 2009

An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy

por Nichols, Eva-Maria, Barbour, Thomas D, Pappworth, Isabel Y, Wong, Edwin K S, Palmer, Jeremy M, Sheerin, Neil S, Pickering, Matthew C, Marchbank, Kevin J
Publicado 2015

Determining the Potential of DNA Damage Response (DDR) Inhibitors in Cervical Cancer Therapy

por Saha, Santu, Rundle, Stuart, Kotsopoulos, Ioannis C., Begbie, Jacob, Howarth, Rachel, Pappworth, Isabel Y., Mukhopadhyay, Asima, Kucukmetin, Ali, Marchbank, Kevin J., Curtin, Nicola
Publicado 2022

Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration

por Hallam, Thomas M., Marchbank, Kevin J., Harris, Claire L., Osmond, Clive, Shuttleworth, Victoria G., Griffiths, Helen, Cree, Angela J., Kavanagh, David, Lotery, Andrew J.
Publicado 2020

A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice

por He, Yong-Gang, Pappworth, Isabel Y., Rossbach, Andreas, Paulin, Joshua, Mavimba, Tarirai, Hayes, Christine, Kulik, Liudmila, Holers, V.Michael, Knight, Andrew M., Marchbank, Kevin J.
Publicado 2018

Thermal stability, storage and release of proteins with tailored fit in silica

por Chen, Yun-Chu, Smith, Tristan, Hicks, Robert H., Doekhie, Aswin, Koumanov, Francoise, Wells, Stephen A., Edler, Karen J., van den Elsen, Jean, Holman, Geoffrey D., Marchbank, Kevin J., Sartbaeva, Asel
Publicado 2017

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

por Smith-Jackson, Kate, Yang, Yi, Denton, Harriet, Pappworth, Isabel Y., Cooke, Katie, Barlow, Paul N., Atkinson, John P., Liszewski, M. Kathryn, Pickering, Matthew C., Kavanagh, David, Cook, H. Terence, Marchbank, Kevin J.
Publicado 2019

Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice

por Kerr, Heather, Herbert, Andrew P., Makou, Elisavet, Abramczyk, Dariusz, Malik, Talat H., Lomax-Browne, Hannah, Yang, Yi, Pappworth, Isabel Y., Denton, Harriet, Richards, Anna, Marchbank, Kevin J., Pickering, Matthew C., Barlow, Paul N.
Publicado 2021

Atypical hemolytic uremic syndrome in the era of terminal complement inhibition: an observational cohort study

por Brocklebank, Vicky, Walsh, Patrick R., Smith-Jackson, Kate, Hallam, Thomas M., Marchbank, Kevin J., Wilson, Valerie, Bigirumurame, Theophile, Dutt, Tina, Montgomery, Emma K., Malina, Michal, Wong, Edwin K. S., Johnson, Sally, Sheerin, Neil S., Kavanagh, David
Publicado 2023

A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration

por Hallam, Thomas M., Cox, Thomas E., Smith-Jackson, Kate, Brocklebank, Vicky, Baral, April J., Tzoumas, Nikolaos, Steel, David H., Wong, Edwin K. S., Shuttleworth, Victoria G., Lotery, Andrew J., Harris, Claire L., Marchbank, Kevin J., Kavanagh, David
Publicado 2022

Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant

por Yang, Yi, Back, Catherine R., Gräwert, Melissa A., Wahid, Ayla A., Denton, Harriet, Kildani, Rebecca, Paulin, Joshua, Wörner, Kristin, Kaiser, Wolgang, Svergun, Dmitri I., Sartbaeva, Asel, Watts, Andrew G., Marchbank, Kevin J., van den Elsen, Jean M. H.
Publicado 2019

Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice

por Kamala, Ola, Malik, Talat H., Hallam, Thomas M., Cox, Thomas E., Yang, Yi, Vyas, Falguni, Luli, Saimir, Connelly, Chloe, Gibson, Beth, Smith-Jackson, Kate, Denton, Harriet, Pappworth, Isabel Y., Huang, Lei, Kavanagh, David, Pickering, Matthew C., Marchbank, Kevin J.
Publicado 2021

Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage

por Malik, Talat H., Gitterman, Daniel P., Lavin, Deborah P., Lomax-Browne, Hannah J., Hiemeyer, E. Christina, Moran, Linda B., Boroviak, Katharina, Cook, H. Terence, Gilmore, Alyssa C., Mandwie, Mawj, Ahmad, Amina, Alexander, Ian E., Logan, Grant J., Marchbank, Kevin J., Bradley, Allan, Pickering, Matthew C.
Publicado 2021

Insights Into the Structure-Function Relationships of Dimeric C3d Fragments

por Wahid, Ayla A., Dunphy, Rhys W., Macpherson, Alex, Gibson, Beth G., Kulik, Liudmila, Whale, Kevin, Back, Catherine, Hallam, Thomas M., Alkhawaja, Bayan, Martin, Rebecca L., Meschede, Ingrid, Laabei, Maisem, Lawson, Alastair D. G., Holers, V. Michael, Watts, Andrew G., Crennell, Susan J., Harris, Claire L., Marchbank, Kevin J., van den Elsen, Jean M. H.
Publicado 2021

Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland

por Brocklebank, Vicky, Johnson, Sally, Sheerin, Thomas P., Marks, Stephen D., Gilbert, Rodney D., Tyerman, Kay, Kinoshita, Meredith, Awan, Atif, Kaur, Amrit, Webb, Nicholas, Hegde, Shivaram, Finlay, Eric, Fitzpatrick, Maggie, Walsh, Patrick R., Wong, Edwin K.S., Booth, Caroline, Kerecuk, Larissa, Salama, Alan D., Almond, Mike, Inward, Carol, Goodship, Timothy H., Sheerin, Neil S., Marchbank, Kevin J., Kavanagh, David
Publicado 2017

Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy

por Brocklebank, Vicky, Kumar, Gurinder, Howie, Alexander J., Chandar, Jayanthi, Milford, David V., Craze, Janet, Evans, Jonathan, Finlay, Eric, Freundlich, Michael, Gale, Daniel P., Inward, Carol, Mraz, Martin, Jones, Caroline, Wong, William, Marks, Stephen D., Connolly, John, Corner, Bronte M., Smith-Jackson, Kate, Walsh, Patrick R., Marchbank, Kevin J., Harris, Claire L., Wilson, Valerie, Wong, Edwin K.S., Malina, Michal, Johnson, Sally, Sheerin, Neil S., Kavanagh, David
Publicado 2020