Targeting redox biology to reverse mitochondrial dysfunction

por Marcinek, David J., Siegel, Michael P.
Publicado 2013

The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function

por Kramer, Philip A., Duan, Jicheng, Qian, Wei-Jun, Marcinek, David J.
Publicado 2015

Mitochondrial oxidative stress in aging and healthspan

por Dai, Dao-Fu, Chiao, Ying Ann, Marcinek, David J, Szeto, Hazel H, Rabinovitch, Peter S
Publicado 2014

Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

por Zhang, Huiliang, Alder, Nathan N, Wang, Wang, Szeto, Hazel, Marcinek, David J, Rabinovitch, Peter S
Publicado 2020

Age and Sex as Determinants of Acute Domoic Acid Toxicity in a Mouse Model

por Hendrix, Alicia M., Lefebvre, Kathi A., Bowers, Emily K., Stuppard, Rudolph, Burbacher, Thomas, Marcinek, David J.
Publicado 2023

ATP and NAD(+) Deficiency in Parkinson’s Disease

por Mischley, Laurie K., Shankland, Eric, Liu, Sophia Z., Bhayana, Saakshi, Fox, Devon J., Marcinek, David J.
Publicado 2023

A novel mitochondrial complex I ROS inhibitor partially improves muscle regeneration in adult but not old mice

por Pharaoh, Gavin, Ostrom, Ethan L., Stuppard, Rudy, Campbell, Matthew, Borghardt, Jens Markus, Franti, Michael, Filareto, Antonio, Marcinek, David J.
Publicado 2023

Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects

por Crouch, Marie-Laure, Knowels, Gary, Stuppard, Rudolph, Ericson, Nolan G., Bielas, Jason H., Marcinek, David J., Syrjala, Karen L.
Publicado 2017

Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption

por Valencia, Ana P., Whitson, Jeremy A., Wang, Shari, Nguyen, Leon, den Hartigh, Laura J., Rabinovitch, Peter S., Marcinek, David J.
Publicado 2022

Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly

por Liu, Sophia Z., Ali, Amir S., Campbell, Matthew D., Kilroy, Kevin, Shankland, Eric G., Roshanravan, Baback, Marcinek, David J., Conley, Kevin E.
Publicado 2018

Astaxanthin supplementation enhances metabolic adaptation with aerobic training in the elderly

por Liu, Sophia Z., Valencia, Ana P., VanDoren, Matt P., Shankland, Eric G., Roshanravan, Baback, Conley, Kevin E., Marcinek, David J.
Publicado 2021

Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial

por Liu, Sophia, D’Amico, Davide, Shankland, Eric, Bhayana, Saakshi, Garcia, Jose M., Aebischer, Patrick, Rinsch, Chris, Singh, Anurag, Marcinek, David J.
Publicado 2022

Age modifies respiratory complex I and protein homeostasis in a muscle type‐specific manner

por Kruse, Shane E., Karunadharma, Pabalu P., Basisty, Nathan, Johnson, Richard, Beyer, Richard P., MacCoss, Michael J., Rabinovitch, Peter S., Marcinek, David J.
Publicado 2015

Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle

por Kramer, Philip A., Duan, Jicheng, Gaffrey, Matthew J., Shukla, Anil K., Wang, Lu, Bammler, Theo K., Qian, Wei-Jun, Marcinek, David J.
Publicado 2018

Reduced Coupling of Oxidative Phosphorylation In Vivo Precedes Electron Transport Chain Defects Due to Mild Oxidative Stress in Mice

por Siegel, Michael P., Kruse, Shane E., Knowels, Gary, Salmon, Adam, Beyer, Richard, Xie, Hui, Van Remmen, Holly, Smith, Steven R., Marcinek, David J.
Publicado 2011

In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial

por Roshanravan, Baback, Liu, Sophia Z., Ali, Amir S., Shankland, Eric G., Goss, Chessa, Amory, John K., Robertson, H. Thomas, Marcinek, David J., Conley, Kevin E.
Publicado 2021

Discovery of a Potential Human Serum Biomarker for Chronic Seafood Toxin Exposure Using an SPR Biosensor

por Lefebvre, Kathi A., Yakes, Betsy Jean, Frame, Elizabeth, Kendrick, Preston, Shum, Sara, Isoherranen, Nina, Ferriss, Bridget E., Robertson, Alison, Hendrix, Alicia, Marcinek, David J., Grattan, Lynn
Publicado 2019

A Novel Antibody-Based Biomarker for Chronic Algal Toxin Exposure and Sub-Acute Neurotoxicity

por Lefebvre, Kathi A., Frame, Elizabeth R., Gulland, Frances, Hansen, John D., Kendrick, Preston S., Beyer, Richard P., Bammler, Theo K., Farin, Frederico M., Hiolski, Emma M., Smith, Donald R., Marcinek, David J.
Publicado 2012

Ice seals as sentinels for algal toxin presence in the Pacific Arctic and subarctic marine ecosystems

por Hendrix, Alicia M., Lefebvre, Kathi A., Quakenbush, Lori, Bryan, Anna, Stimmelmayr, Raphaela, Sheffield, Gay, Wisswaesser, Gabriel, Willis, Maryjean L., Bowers, Emily K., Kendrick, Preston, Frame, Elizabeth, Burbacher, Thomas, Marcinek, David J.
Publicado 2021

The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)

por Pharaoh, Gavin, Kamat, Varun, Kannan, Sricharan, Stuppard, Rudolph S., Whitson, Jeremy, Martín-Pérez, Miguel, Qian, Wei-Jun, MacCoss, Michael J., Villén, Judit, Rabinovitch, Peter, Campbell, Matthew D., Sweet, Ian R., Marcinek, David J.
Publicado 2023